Upstream Bio Share Price (NASDAQ: UPB)

$17.14

▲

0.38

(2.27%)

Last updated on August 30, 2025 at 1:29 am IST

$₹

Check the interactive Upstream Bio Stock chart to analyse performance

Upstream Bio stock performance

as on August 30, 2025 at 1:29 am IST

Today's Low:$16.51
Today's High:$17.14
$17.14
3.68%
Downside
Day's Volatility :3.68%
Upside
0.0%
52 Weeks Low:$5.14
52 Weeks High:$29.46
$17.14
70.01%
Downside
52 Weeks Volatility :82.55%
Upside
41.82%

Upstream Bio Stock Returns

Period	Upstream Bio Inc.	Index (Russel 2000)
3 Months	60.79%	0.0%
6 Months	129.76%	0.0%
1 Year	-22.09%	0.0%
3 Years	-22.09%	-4.7%

Upstream Bio Inc. Key Stats

Check Upstream Bio key stats like market cap, P/E ratio, EPS, Dividend Yield, and more.

Previous Close	$16.76
Open	$16.7
Today's High	$17.14
Today's Low	$16.51
Market Capitalization	$407.3M
Today's Volume	$305.7K
52 Week High	$29.4599
52 Week Low	$5.14
Revenue TTM	$2.2M
EBITDA	$-65.7M
Earnings Per Share (EPS)	$-1.36
Profit Margin	0.0%
Quarterly Earnings Growth YOY	0.0%
Return On Equity TTM	0.0%

Stock Returns calculator for Upstream Bio Stock including INR - Dollar returns

The Upstream Bio stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Return is the profit earned when the US dollar rises in value compared to the Indian rupee.

Investment Value

₹1,00,000

Upstream Bio investment value today

Current value as on today

₹83,193

Returns

₹16,807

(-16.81%)

Returns from Upstream Bio Stock

₹22,091 (-22.09%)

Dollar Returns*

₹5,284 (+5.28%)

Indian investors sentiment towards Upstream Bio Stock

-10%

Period: Jul 31, 2025 to Aug 30, 2025. Change in 30 Days versus previous period

Search interest for Upstream Bio Stock from India on INDmoney has decreased by -10% in the last 30 days, reflecting a downward trend in search activity.

Analyst Recommendation on Upstream Bio Stock

Rating

Trend

Upstream Bio Share Price Target

What analysts predicted

Upside of 229.64%

Target:

$56.50

Current:

$17.14

Upstream Bio share price target is $56.50, a slight Upside of 229.64% compared to current price of $17.14 as per analysts' prediction.

Upstream Bio Stock Insights

Price Movement
In the last 3 months, UPB stock has moved up by 85.7%

Upstream Bio Inc. Financials

Revenue

Profit

Cash Flow

Annually

Quarterly

FY22

FY23

FY24

	FY22	Y/Y Change
Revenue	$1.2M	-
Net Income	$-23.9M	-
Net Profit Margin	-2.0K%	-

	FY23	Y/Y Change
Revenue	$2.4M	↑ 96.37%
Net Income	$-20.5M	↓ 13.96%
Net Profit Margin	-862.9%	↑ 1106.41%

	FY24	Y/Y Change
Revenue	$2.4M	↓ 0.42%
Net Income	$-62.8M	↑ 205.82%
Net Profit Margin	-2.7K%	↓ 1787.14%

Q1 FY24

Q2 FY24

Q3 FY24

Q4 FY24

Q1 FY25

Q2 FY25

	Q1 FY24	Q/Q Change
Revenue	$640.0K	↑ 42.22%
Net Income	$-10.9M	↓ 7.94%
Net Profit Margin	-1.7K%	↑ 927.37%

	Q2 FY24	Q/Q Change
Revenue	$510.0K	↓ 20.31%
Net Income	$-14.7M	↑ 34.73%
Net Profit Margin	-2.9K%	↓ 1175.85%

	Q3 FY24	Q/Q Change
Revenue	$607.0K	↑ 19.02%
Net Income	$-16.0M	↑ 8.95%
Net Profit Margin	-2.6K%	↑ 243.44%

	Q4 FY24	Q/Q Change
Revenue	$613.0K	↑ 0.99%
Net Income	$-21.2M	↑ 32.83%
Net Profit Margin	-3.5K%	↓ 830.65%

	Q1 FY25	Q/Q Change
Revenue	$566.0K	↓ 7.67%
Net Income	$-27.3M	↑ 28.38%
Net Profit Margin	-4.8K%	↓ 1352.77%

	Q2 FY25	Q/Q Change
Revenue	$937.0K	↑ 65.55%
Net Income	$-40.0M	↑ 46.56%
Net Profit Margin	-4.3K%	↑ 552.71%

FY22

FY23

FY24

	FY22	Y/Y Change
Profit	$1.2M	-

	FY23	Y/Y Change
Profit	$2.4M	↑ 96.37%

	FY24	Y/Y Change
Profit	$2.4M	↓ 0.42%

Q1 FY24

Q2 FY24

Q3 FY24

Q4 FY24

Q1 FY25

Q2 FY25

	Q1 FY24	Q/Q Change
Profit	$640.0K	↑ 42.22%

	Q2 FY24	Q/Q Change
Profit	$510.0K	↓ 20.31%

	Q3 FY24	Q/Q Change
Profit	$607.0K	↑ 19.02%

	Q4 FY24	Q/Q Change
Profit	$613.0K	↑ 0.99%

	Q1 FY25	Q/Q Change
Profit	$566.0K	↓ 7.67%

	Q2 FY25	Q/Q Change
Profit	$937.0K	↑ 65.55%

FY22

FY23

FY24

	FY22	Y/Y Change
Operating Cash Flow	$-19.0M	-
Investing Cash Flow	$-82.0K	-
Financing Cash Flow	$10.0M	-

	FY23	Y/Y Change
Operating Cash Flow	$-37.9M	↑ 99.39%
Investing Cash Flow	$-82.8M	↑ 100926.83%
Financing Cash Flow	$129.6M	↑ 1200.31%

	FY24	Y/Y Change
Operating Cash Flow	$-59.2M	↑ 56.02%
Investing Cash Flow	$-59.5M	↓ 28.19%
Financing Cash Flow	$418.9M	↑ 223.36%

Q1 FY24

Q2 FY24

Q3 FY24

Q4 FY24

Q1 FY25

Q2 FY25

	Q1 FY24	Q/Q Change
Operating Cash Flow	$-17.6M	↑ 9.01%
Investing Cash Flow	$13.9M	↓ 364.25%
Financing Cash Flow	$9.4M	↓ 7157.89%

	Q2 FY24	Q/Q Change
Operating Cash Flow	$-8.0M	↓ 54.24%
Investing Cash Flow	$-116.7M	↓ 942.15%
Financing Cash Flow	$140.5M	↑ 1396.92%

	Q3 FY24	Q/Q Change
Operating Cash Flow	$-14.0M	↑ 73.74%
Investing Cash Flow	$1.4M	↓ 101.21%
Financing Cash Flow	$-1.6M	↓ 101.17%

	Q4 FY24	Q/Q Change
Operating Cash Flow	$-19.6M	↑ 40.47%
Investing Cash Flow	$41.9M	↑ 2874.31%
Financing Cash Flow	$270.6M	↓ 16592.87%

	Q1 FY25	Q/Q Change
Operating Cash Flow	$-41.2M	↑ 109.9%
Investing Cash Flow	$-213.4M	↓ 609.17%
Financing Cash Flow	$-34.0K	↓ 100.01%

	Q2 FY25	Q/Q Change
Operating Cash Flow	$-39.2M	↓ 4.68%
Investing Cash Flow	$12.8M	↓ 105.99%
Financing Cash Flow	$612.0K	↓ 1900.0%

Upstream Bio Technicals Summary

Sell

Neutral

Buy

Upstream Bio is currently in a favorable trading position ( BUY ) according to technical analysis indicators.

Upstream Bio Inc. Vs Peers

Returns

Ratio's

Overview

Company Name	1 Month	6 Month	1 Year	3 Years	5 Years
Upstream Bio Inc.	10.3%	129.76%	-22.09%	-22.09%	-22.09%
Regeneron Pharmaceuticals, Inc.	6.48%	-15.2%	-50.31%	-3.3%	-2.01%
Beone Medicines Ltd	1.77%	24.81%	62.78%	79.11%	29.69%
Vertex Pharmaceuticals Incorporated	-14.45%	-19.13%	-17.84%	34.68%	41.87%
Alnylam Pharmaceuticals, Inc.	13.79%	83.28%	75.87%	111.28%	242.25%

Company Name	P/E Ratio	P/B Ratio	PEG Ratio	EPS	ROE	ROA	Div Yield	BVPS
Upstream Bio Inc.	NA	NA	NA	-4.3	0.0	0.0	NA	-52.99
Regeneron Pharmaceuticals, Inc.	14.6	14.6	1.2	39.42	0.15	0.07	0.0	287.55
Beone Medicines Ltd	NA	NA	NA	2.73	-0.05	-0.01	NA	34.32
Vertex Pharmaceuticals Incorporated	27.86	27.86	0.58	18.06	0.23	0.13	NA	67.02
Alnylam Pharmaceuticals, Inc.	NA	NA	-0.49	3.92	-2.58	-0.03	NA	1.91

Company Name	Analyst View	Market Cap	5 Years Return %	PE Ratio	Profit Margin
Upstream Bio Inc.	NA	$407.3M	-22.09%	NA	0.0%
Regeneron Pharmaceuticals, Inc.	Buy	$61.4B	-2.01%	14.6	31.37%
Beone Medicines Ltd	NA	$36.5B	29.69%	NA	-3.89%
Vertex Pharmaceuticals Incorporated	Buy	$100.5B	41.87%	27.86	31.86%
Alnylam Pharmaceuticals, Inc.	Buy	$59.5B	242.25%	NA	-12.96%

About Upstream Bio Inc.

Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases focusing on severe respiratory disorders. Its product candidate includes verekitug, which is in Phase 2 clinical development for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps, as well as in Phase I clinical trial for treating chronic obstructive pulmonary disease. The company was incorporated in 2021 and is headquartered in Waltham, Massachusetts.

Organization	Upstream Bio
Employees	52
CEO	Dr. E. Rand Sutherland M.D., M.P.H., MPH
Industry	Miscellaneous

Key Management of Upstream Bio Inc.

Name	Title
Dr. E. Rand Sutherland M.D., M.P.H., MPH	CEO & Director
Mr. Michael Paul Gray CPA, MBA	CFO & COO
Ms. Allison C. Ambrose J.D.	Senior VP, General Counsel & Secretary
Ms. Stacy Price M.S., P.M.P.	Chief Technology Officer
Ms. Lisa Fiering	Senior Vice President of People & Culture
Dr. Adam Houghton M.B.A., Ph.D.	Chief Business Officer
Mr. Aaron Deykin M.D.	Chief Medical Officer and Head of Research & Development
Ms. Mersedeh Miraliakbari Pharm.D.	Senior Vice President of Regulatory Affairs & Quality
Ms. Fang Xie Ph.D.	VP & Head of Biometrics
Dr. Sumathi Sivapalasingam M.D.	VP & Head of Clinical Development

Important FAQs about investing in UPB Stock from India :

What is Upstream Bio share price today?

Upstream Bio share price today is $17.14 as on August 30, 2025 at 1:29 am IST at the close of the market. Upstream Bio share today touched a day high of $17.14 and a low of $16.51.

What is the 52 week high and 52 week low for Upstream Bio share?

Upstream Bio share touched a 52 week high of $29.46 and a 52 week low of $5.14. Upstream Bio stock price today i.e. August 30, 2025 at 1:29 am IST is closed at $17.14, lower by 41.82% versus the 52 week high.

How to invest in Upstream Bio Stock (UPB) from India?

Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
Step 2: Search for Upstream Bio on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Upstream Bio Shares that will get you 0.0875 shares as per Upstream Bio share price of $17.14 per share as on August 30, 2025 at 1:29 am IST.

What is the minimum amount required to buy Upstream Bio Stock (UPB) from India?

Indian investors can start investing in Upstream Bio (UPB) shares with as little as ₹88.286 or $1 (as of August 31, 2025) using the INDmoney app.
For example: If you want to invest $10 or ₹882.86 in Upstream Bio stock (as per the Rupee-Dollar exchange rate as on August 31, 2025). Based on Upstream Bio share’s latest price of $17.14 as on August 30, 2025 at 1:29 am IST, you will get 0.5834 shares of Upstream Bio. Learn more about fractional shares .

What are the returns that Upstream Bio has given to Indian investors in the last 5 years?

Upstream Bio stock has given -22.09% share price returns and 20.51% dollar appreciation to an Indian investor in the last 5 years.
Read more about How do Currency Exchange Rates impact your returns on US Stock Investments?