Upstream Bio, Inc. share price logo

Upstream Bio, Inc.

NASDAQ: UPB

Small Cap

$5.49

+0.12

(+2.33%)

Live

as on

Upstream Bio, Inc. Stock Performance

as on September 23, 2026 at 5:17 am IST

  • Day's Low

    Day's High

    $5.38
    $5.52
    downward going graph

    2.00%

    Downside

    0.55%

    Upside

    downward going graph
  • 52 Week's Low

    52 Week's High

    $5.21
    $33.68
    downward going graph

    5.10%

    Downside

    513.48%

    Upside

    downward going graph

Upstream Bio, Inc. share price movements today

Previous Close
$5.37
Open
$5.46
Volume
256.5K
Market Cap
$292.5M
Day's Low - High
$5.38 - $5.52
52 Week Low - High
$5.21 - $33.68

Upstream Bio, Inc. Historical Returns

1 Month Return
-23.03 %
3 Month Return
-14.84 %
1 Year Return
-67.78 %
3 Year Return
0 %
5 Year Return
0 %

Upstream Bio, Inc. Stock Fundamentals & Key Indicators

Check Upstream Bio, Inc. market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$292.5M

EPS (TTM)

-2.9034

Dividend Yield

0.00%

PE Ratio (TTM)

0

PEG Ratio

0

Return On Equity TTM

-46.05%

Upstream Bio, Inc. vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Upstream Bio, Inc. with its industry peers.

Company
Analyst View
Market Cap
5 Years Return %PE RatioProfit Margin %Dividend Yield %
StrongBuy$292.5MNANA0.00%0.00%
Neutral$61.5B-60.76%-19.3-12.57%0.00%
StrongBuy$128.8B177.16%29.3586.04%0.00%
Buy$80.8B23.35%18.4884.86%0.47%

Stock Returns calculator for Upstream Bio, Inc. Stock including INR - Dollar returns

The Upstream Bio, Inc. stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Impact: The bonus return you make when the US Dollar rises against the Rupee; calculated on the full amount you walk away with, not just what you invested in.

Investment Value

₹1,00,000

  • 1Y

Upstream Bio, Inc. investment value today

Current value as on today

₹35,690

Returns

-₹64,310

(-64.31%)

Returns from Upstream Bio, Inc. Stock

-₹67,027 (-67.03%)

Dollar Impact

₹2,717 (+2.72%)

Analyst Recommendation on Upstream Bio, Inc. Stock

Based on 6 analysts

BUY

83.33%

Buy

16.67%

Hold

0.00%

Sell

Based on 6 analysts, 83.33333333333334% of analysts recommend a 'BUY' rating for Upstream Bio, Inc.. Average target price of $32.8

Indian Investors' Interest in Upstream Bio, Inc. Stock

Search interest for Upstream Bio, Inc. Stock has increased by 31% in the last 30 days, reflecting an upward trend in search activity.

Time period: to

Change:31% versus previous 30 day period

Upstream Bio, Inc. Quarterly Profit & Loss

All numbers in Millions USD

Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Mar 2026
Jun 2026
Total Revenue
0
0
0
0
0
0
0
0
1
0
Gross Profit
0
0
0
0
0
0
0
0
0
0
Operating Income
-15
-17
-18
-26
-32
-44
-37
-46
-43
-42
EBITDA
-10
-14
-15
-21
-27
-39
-33
-42
-40
-39
Interest Expense
-
-
-
-
-
-
-
-
-
-
Depreciation
0
0
0
0
0
0
0
0
0
0
Income Before Tax
-10
-14
-15
-21
-27
-39
-33
-42
-40
-39
Income Tax Expense
-
-
-
-
-
-
-
-
-
-
Net Income
-10
-14
-15
-21
-27
-39
-33
-42
-40
-39
Net Profit Margin
-1702.19%
-2878.04%
-2634.60%
-3465.25%
-4818.02%
-4265.31%
-4941.14%
-6356.14%
-3925.63%
-5136.09%

Upstream Bio, Inc. Annual Profit & Loss

All numbers in Millions USD

Dec 2022
Dec 2023
Dec 2024
Dec 2025
Total Revenue
1
2
2
2
Gross Profit
1
2
2
2
Operating Income
-23
-40
-77
-160
EBITDA
-23
-20
-62
-143
Interest Expense
-
-
-
-
Depreciation
0
0
0
0
Income Before Tax
-23
-20
-62
-143
Income Tax Expense
-
-
-
-
Net Income
-23
-20
-62
-143
Net Profit Margin
-1969.31%
-862.90%
-2650.04%
-5026.03%

Upstream Bio, Inc. Quarterly Cash Flow

All numbers in Millions USD

Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Mar 2026
Jun 2026
Net Income
-14
-15
-21
-27
-39
-33
-42
-40
-39
Operating Cash Flow
-8
-13
-19
-41
-39
-22
-30
-47
-35
Investing Cash Flow
-116
1
41
-213
12
48
58
42
15
Financing Cash Flow
140
-1
270
0
0
0
1
0
2
Change in Cash
15
-14
292
-254
-25
26
29
-4
-17

Upstream Bio, Inc. Annual Cash Flow

All numbers in Millions USD

Dec 2023
Dec 2024
Dec 2025
Net Income
-20
-62
-143
Operating Cash Flow
-37
-59
-133
Investing Cash Flow
-82
-59
-93
Financing Cash Flow
129
418
2
Change in Cash
8
300
-224

Mutual Funds that own Upstream Bio, Inc. Stock

Check out the Mutual Funds with significant holdings in Upstream Bio, Inc..

Funds
Holdings
Shares Held
Fidelity Securities Fund
5.533562%
3030790
VANGUARD INDEX FUNDS
3.334773%
1826490
Fidelity Capital Trust
2.413319%
1321800
Fidelity Advisor Series VII
1.991934%
1091003
Fidelity Select Portfolios
1.889058%
1034657

Global Institutional Holdings in Upstream Bio, Inc.

Funds
Holdings
Vanguard
3.97%
iShares
3.05%
Otello Stampacchia
2.42%
Michael Rockefeller
1.52%
Dimensional
0.44%

Upstream Bio, Inc. News & Key Events

  • img

    Today's Timeline - 01 September

    Tue, 04:30 PM

    -

    Upstream Bio outlines Phase 3 trials for verekitug in severe asthma and CRSwNP, starting Q1 2027 with 1,500 patients.

Insights on Upstream Bio, Inc.

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

  • imgNO EFFECT

    Against Peers

    img

    In the last 1 year, Moderna, Inc. Common Stock has given 551.1% return, outperforming this stock by 618.9%

  • imgNEGATIVE IMPACT

    Price Dip

    img

    In the last 1 month, UPB stock has moved down by -23.0%

About Upstream Bio, Inc.

Upstream Bio, Inc. is a biotechnology company in the clinical development stage, dedicated to innovating therapies for inflammatory conditions, particularly those affecting the severe respiratory system. Its pipeline notably features verekitug, a monoclonal antibody designed to selectively target and suppress the thymic stromal lymphopoietin receptor. Beyond this, the company is actively developing treatments for severe asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease. Established in 2021, Upstream Bio maintains its operational base in Waltham, Massachusetts.
OrganisationUpstream Bio, Inc.
Headquarters890 Winter Street, Waltham, MA, 02451, US
IndustryBiotechnology
CEOE. Rand Sutherland
E-voting on sharesClick here to vote

Key Management of Upstream Bio, Inc.

Name

Title

Mr. Michael Paul Gray CPA, MBA

CFO & COO

Mr. Aaron Deykin M.D.

Chief Medical Officer and Head of Research & Development

Ms. Stacy Price M.S., P.M.P.

Chief Technology Officer

Meggan Buckwell

Director of Corporate Communications & Investor Relations

Dr. Adam Houghton M.B.A., Ph.D.

Chief Business Officer

Dr. E. Rand Sutherland M.D., M.P.H.

CEO & Director

Ms. Allison C. Ambrose J.D.

Senior VP, General Counsel & Secretary

Ms. Lisa Fiering

Senior Vice President of People & Culture

Ms. Mersedeh Miraliakbari Pharm.D.

Senior Vice President of Regulatory Affairs & Quality

Ms. Fang Xie Ph.D.

VP & Head of Biometrics

FAQs

What is Upstream Bio, Inc. share price today?

Upstream Bio, Inc. share price today is $5.49 as on . Upstream Bio, Inc. share today touched a day high of $5.52 and a low of $5.38.

What is the 52 week high and 52 week low for Upstream Bio, Inc. share?

Upstream Bio, Inc. share touched a 52 week high of $33.68 on and a 52 week low of $5.21 on . Upstream Bio, Inc. stock price today i.e. is trending at $5.49,which is 83.70% down from its 52 week high and 5.37% up from its 52 week low.

What is Upstream Bio, Inc.'s market capitalisation today?

Upstream Bio, Inc. market capitalisation is $0.00T as on .

How to invest in Upstream Bio, Inc. Stock (UPB) from India?

  1. Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
  2. Step 2: Search for Upstream Bio, Inc. on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Upstream Bio, Inc. Shares that will get you 0.2732 shares as per Upstream Bio, Inc. share price of $5.49 per share as on September 22, 2026 at 11:47 pm IST.

What is the minimum amount required to buy Upstream Bio, Inc. Stock (UPB) from India?

Indian investors can start investing in Upstream Bio, Inc. (UPB) shares with as little as ₹95.58 or $1 (as of ) using the INDmoney app.
For example: If you want to invest $10 or ₹955.80 in Upstream Bio, Inc. stock (as per the Rupee-Dollar exchange rate as on ). Based on Upstream Bio, Inc. share’s latest price of $5.49 as on September 22, 2026 at 11:47 pm IST, you will get 1.8215 shares of Upstream Bio, Inc.. Learn more about fractional shares .