Upstream Bio Inc. share price logo

Upstream Bio Inc. Share Price

NASDAQ: UPB

Small Cap

$20.95

-1.33

(-5.97%)

as on

Upstream Bio Inc. Stock Performance

as on October 18, 2025 at 1:29 am IST

  • Day's Low

    Day's High

    $20.65
    $22.15
    downward going graph

    1.43%

    Downside

    5.73%

    Upside

    downward going graph

  • 52 Week's Low

    52 Week's High

    $5.14
    $29.46
    downward going graph

    75.47%

    Downside

    40.62%

    Upside

    downward going graph

Upstream Bio Inc. share price movements today

Previous Close
$22.28
Open
$22.15
Volume
403.4K
Day's Low - High
$20.65 - $22.15
52 Week Low - High
$5.14 - $29.46

Upstream Bio Inc. Historical Returns

1 Month Return
+ 28.02 %
3 Month Return
+ 95.62 %
1 Year Return
-18.97 %
3 Year Return
0 %
5 Year Return
0 %

Upstream Bio Inc. Stock Fundamentals & Key Indicators

Check Upstream Bio Inc. market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$1.1B

EPS (TTM)

-2.8247

Dividend Yield

0.00%

PE Ratio (TTM)

0

PEG Ratio

0

Return On Equity TTM

1064900.00%

Upstream Bio Inc. vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Upstream Bio Inc. with its industry peers.

Company
Analyst View
Market Cap
5 Years Return %PE RatioProfit Margin %
Upstream Bio Inc. image
Upstream Bio Inc.
NA$1.1BNANA0.00%
Alnylam Pharmaceuticals, Inc. image
Alnylam Pharmaceuticals, Inc.
BUY$63.1B240.52%-505.15-12.96%
Beone Medicines Ltd image
Beone Medicines Ltd
NA$35.3BNANA-3.89%
Vertex Pharmaceuticals Incorporated image
Vertex Pharmaceuticals Incorporated
BUY$106.9B94.28%29.6731.86%
Regeneron Pharmaceuticals, Inc. image
Regeneron Pharmaceuticals, Inc.
BUY$61.3B0.25%14.5831.37%

Stock Returns calculator for Upstream Bio Inc. Stock including INR - Dollar returns

The Upstream Bio Inc. stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Return is the profit earned when the US dollar rises in value compared to the Indian rupee.

Investment Value

₹1,00,000

  • 1Y

Upstream Bio Inc. investment value today

Current value as on today

₹85,745

Returns

₹14,255

(-14.25%)

Returns from Upstream Bio Inc. Stock

₹19,049 (-19.05%)

Dollar Returns*

₹4,794 (+4.79%)

Upstream Bio Inc. Stock’s Investor Sentiment and Interest

Search interest for Upstream Bio Inc. Stock has increased by 8% in the last 30 days, reflecting an upward trend in search activity.

Time period: to

Change:8% versus previous 30 day period

Upstream Bio Inc. Quarterly Profit & Loss

All numbers in Millions USD

Sep 2023
Dec 2023
Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Total Revenue
0
0
0
0
0
0
0
0
Gross Profit
0
0
0
0
0
0
0
0
Operating Income
-9
-14
-15
-17
-18
-26
-32
-44
EBITDA
-9
-14
-15
-17
-18
-26
-31
-44
Interest Expense
-
-
-
-
-
-
-
-
Depreciation
0
0
0
0
0
0
0
0
Income Before Tax
-3
-11
-10
-14
-15
-21
-27
-39
Income Tax Expense
-
-
-
-
-
-
-
-
Net Income
-3
-11
-10
-14
-15
-21
-27
-39
Net Profit Margin
-499.52%
-2629.56%
-1702.19%
-2878.04%
-2634.60%
-3465.25%
-4818.02%
-4265.31%

Upstream Bio Inc. Annual Profit & Loss

All numbers in Millions USD

Dec 2022
Dec 2023
Dec 2024
Total Revenue
1
2
2
Gross Profit
1
2
2
Operating Income
-23
-40
-77
EBITDA
-23
-40
-77
Interest Expense
-
-
-
Depreciation
0
0
0
Income Before Tax
-23
-20
-62
Income Tax Expense
-
-
-
Net Income
-23
-20
-62
Net Profit Margin
-1969.31%
-862.90%
-2650.04%

Upstream Bio Inc. Quarterly Cash Flow

All numbers in Millions USD

Dec 2023
Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Net Income
-11
-10
-14
-15
-21
-27
-39
Operating Cash Flow
-16
-17
-8
-13
-19
-41
-39
Investing Cash Flow
-5
13
-116
1
41
-213
12
Financing Cash Flow
0
9
140
-1
270
0
0
Change in Cash
-21
5
15
-14
292
-254
-25

Upstream Bio Inc. Annual Cash Flow

All numbers in Millions USD

Dec 2023
Dec 2024
Net Income
-20
-62
Operating Cash Flow
-37
-59
Investing Cash Flow
-82
-59
Financing Cash Flow
129
418
Change in Cash
8
300

Insights on Upstream Bio Inc.

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

  • imgPOSITIVE IMPACT

    Price Rise

    img

    In the last 1 month, UPB stock has moved up by 28.0%

  • imgNO EFFECT

    Against Peers

    img

    In the last 1 year, Alnylam Pharmaceuticals, Inc. has given 62.8% return, outperforming this stock by 81.8%

About Upstream Bio Inc.

Upstream Bio, Inc. is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. The Company is developing verekitug, the only known antagonist in clinical development, that targets the receptor for thymic stromal lymphopoietin (TSLP), a cytokine which is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune mediated diseases. It has advanced this highly potent monoclonal antibody into separate phase II trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and plans to initiate development in chronic obstructive pulmonary disease. TSLP is a member of a class of epithelial cytokines, also including IL-25 and IL-33, commonly referred to as alarmins. TSLP is primarily produced by epithelial cells, especially in the lung, gastrointestinal tract and skin.
OrganisationUpstream Bio Inc.
Headquarters890 Winter Street, Waltham, MA, United States, 02451
CEODr. E. Rand Sutherland M.D., M.P.H., MPH
E-voting on sharesClick here to vote

Key Management of Upstream Bio Inc.

Name

Title

Mr. Michael Paul Gray CPA, MBA

CFO & COO

Ms. Allison C. Ambrose J.D.

Senior VP, General Counsel & Secretary

Meggan Buckwell

Director of Corporate Communications & Investor Relations

Mr. Aaron Deykin M.D.

Chief Medical Officer and Head of Research & Development

Ms. Mersedeh Miraliakbari Pharm.D.

Senior Vice President of Regulatory Affairs & Quality

Dr. E. Rand Sutherland M.D., M.P.H., MPH

CEO & Director

Ms. Stacy Price M.S., P.M.P.

Chief Technology Officer

Ms. Lisa Fiering

Senior Vice President of People & Culture

Dr. Adam Houghton M.B.A., Ph.D.

Chief Business Officer

Ms. Fang Xie Ph.D.

VP & Head of Biometrics

FAQs

What is Upstream Bio Inc. share price today?

Upstream Bio Inc. share price today is $20.95 as on at the close of the market. Upstream Bio Inc. share today touched a day high of $22.15 and a low of $20.65.

What is the 52 week high and 52 week low for Upstream Bio Inc. share?

Upstream Bio Inc. share touched a 52 week high of $29.46 on and a 52 week low of $5.14 on . Upstream Bio Inc. stock price today i.e. is closed at $20.95,which is 28.89% down from its 52 week high and 307.59% up from its 52 week low.

What is Upstream Bio Inc.'s market capitalisation today?

Upstream Bio Inc. market capitalisation is $0.00T as on .

How to invest in Upstream Bio Inc. Stock (UPB) from India?

  1. Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
  2. Step 2: Search for Upstream Bio Inc. on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Upstream Bio Inc. Shares that will get you 0.0716 shares as per Upstream Bio Inc. share price of $20.95 per share as on October 18, 2025 at 1:29 am IST.

What is the minimum amount required to buy Upstream Bio Inc. Stock (UPB) from India?

Indian investors can start investing in Upstream Bio Inc. (UPB) shares with as little as ₹87.954 or $1 (as of ) using the INDmoney app.
For example: If you want to invest $10 or ₹879.54 in Upstream Bio Inc. stock (as per the Rupee-Dollar exchange rate as on ). Based on Upstream Bio Inc. share’s latest price of $20.95 as on October 18, 2025 at 1:29 am IST, you will get 0.4773 shares of Upstream Bio Inc.. Learn more about fractional shares .