Upstream Bio Inc. share price logo

Upstream Bio Inc.

NASDAQ: UPB

Small Cap

$7.51

+0.23

(+3.16%)

as on

Upstream Bio Inc. Stock Performance

as on July 3, 2026 at 2:15 pm IST

  • Day's Low

    Day's High

    $7.27
    $7.72
    downward going graph

    3.20%

    Downside

    2.80%

    Upside

    downward going graph
  • 52 Week's Low

    52 Week's High

    $5.85
    $33.68
    downward going graph

    22.10%

    Downside

    348.47%

    Upside

    downward going graph

Upstream Bio Inc. share price movements today

Previous Close
$7.28
Open
$7.31
Volume
280.0K
Day's Low - High
$7.27 - $7.72
52 Week Low - High
$5.85 - $33.68

Upstream Bio Inc. Historical Returns

1 Month Return
-1.57 %
3 Month Return
-20.95 %
1 Year Return
-32.95 %
3 Year Return
0 %
5 Year Return
0 %

Upstream Bio Inc. Stock Fundamentals & Key Indicators

Check Upstream Bio Inc. market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$396.2M

EPS (TTM)

-2.8413

Dividend Yield

0.00%

PE Ratio (TTM)

0

PEG Ratio

0

Return On Equity TTM

-41.83%

Upstream Bio Inc. vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Upstream Bio Inc. with its industry peers.

Company
Analyst View
Market Cap
5 Years Return %PE RatioProfit Margin %Dividend Yield %
NA$396.2MNANA0.00%NA
BUY$39.9B478.19%NA0.00%NA
BUY$40.3B82.45%75.812.55%NA
BUY$126.4B163.31%29.5935.51%NA
BUY$65.5B12.1%15.2529.65%0.5700000000000001%

Stock Returns calculator for Upstream Bio Inc. Stock including INR - Dollar returns

The Upstream Bio Inc. stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Impact: The bonus return you make when the US Dollar rises against the Rupee; calculated on the full amount you walk away with, not just what you invested in.

Investment Value

₹1,00,000

  • 1Y

Upstream Bio Inc. investment value today

Current value as on today

₹74,720

Returns

-₹25,280

(-25.28%)

Returns from Upstream Bio Inc. Stock

-₹32,946 (-32.95%)

Dollar Impact

₹7,666 (+7.67%)

Indian Investors' Interest in Upstream Bio Inc. Stock

Search interest for Upstream Bio Inc. Stock has increased by 35% in the last 30 days, reflecting an upward trend in search activity.

Time period: to

Change:35% versus previous 30 day period

Upstream Bio Inc. Quarterly Profit & Loss

All numbers in Millions USD

Dec 2023
Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Mar 2026
Total Revenue
0
0
0
0
0
0
0
0
0
1
Gross Profit
0
0
0
0
0
0
0
0
0
0
Operating Income
-14
-15
-17
-18
-26
-32
-44
-37
-46
-43
EBITDA
-11
-10
-14
-15
-21
-27
-39
-33
-42
-40
Interest Expense
-
-
-
-
-
-
-
-
-
-
Depreciation
0
0
0
0
0
0
0
0
0
0
Income Before Tax
-11
-10
-14
-15
-21
-27
-39
-33
-42
-40
Income Tax Expense
-
-
-
-
-
-
-
-
-
-
Net Income
-11
-10
-14
-15
-21
-27
-39
-33
-42
-40
Net Profit Margin
-2629.56%
-1702.19%
-2878.04%
-2634.60%
-3465.25%
-4818.02%
-4265.31%
-4941.14%
-6356.14%
-3925.63%

Upstream Bio Inc. Annual Profit & Loss

All numbers in Millions USD

Dec 2022
Dec 2023
Dec 2024
Dec 2025
Total Revenue
1
2
2
2
Gross Profit
1
2
2
2
Operating Income
-23
-40
-77
-160
EBITDA
-23
-20
-62
-143
Interest Expense
-
-
-
-
Depreciation
0
0
0
0
Income Before Tax
-23
-20
-62
-143
Income Tax Expense
-
-
-
-
Net Income
-23
-20
-62
-143
Net Profit Margin
-1969.31%
-862.90%
-2650.04%
-5026.03%

Upstream Bio Inc. Quarterly Cash Flow

All numbers in Millions USD

Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Mar 2026
Net Income
-10
-14
-15
-21
-27
-39
-33
-42
-40
Operating Cash Flow
-17
-8
-13
-19
-41
-39
-22
-30
-47
Investing Cash Flow
13
-116
1
41
-213
12
48
58
42
Financing Cash Flow
9
140
-1
270
0
0
0
1
0
Change in Cash
5
15
-14
292
-254
-25
26
29
-4

Upstream Bio Inc. Annual Cash Flow

All numbers in Millions USD

Dec 2023
Dec 2024
Dec 2025
Net Income
-20
-62
-143
Operating Cash Flow
-37
-59
-133
Investing Cash Flow
-82
-59
-93
Financing Cash Flow
129
418
2
Change in Cash
8
300
-224

Global Institutional Holdings in Upstream Bio Inc.

Funds
Holdings
SEB Asset Management AB
1.61%
Woodline Partners LP
1.53%
D. E. Shaw & Co LP
1.51%
VR Adviser, LLC
2.15%
Parkman Healthcare Partners LLC
1.45%

Insights on Upstream Bio Inc.

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

  • imgPOSITIVE IMPACT

    Price Rise

    img

    In the last 7 days, UPB stock has moved up by 11.3%

  • imgNO EFFECT

    Against Peers

    img

    In the last 1 year, Revolution Medicines, Inc. Common Stock has given 399.7% return, outperforming this stock by 432.6%

About Upstream Bio Inc.

Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases focusing on severe respiratory disorders. It offers verekitug, which is in Phase 2 trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease and in Phase I clinical trial for treating chronic obstructive pulmonary disease. The company was incorporated in 2021 and is headquartered in Waltham, Massachusetts.
OrganisationUpstream Bio Inc.
Headquarters890 Winter Street, Waltham, MA, United States, 02451
IndustryBiotechnology
CEODr. E. Rand Sutherland M.D., M.P.H.
E-voting on sharesClick here to vote

Key Management of Upstream Bio Inc.

Name

Title

Mr. Michael Paul Gray CPA, MBA

CFO & COO

Mr. Aaron Deykin M.D.

Chief Medical Officer and Head of Research & Development

Ms. Stacy Price M.S., P.M.P.

Chief Technology Officer

Dr. Adam Houghton M.B.A., Ph.D.

Chief Business Officer

Ms. Fang Xie Ph.D.

VP & Head of Biometrics

Dr. E. Rand Sutherland M.D., M.P.H.

CEO & Director

Meggan Buckwell

Director of Corporate Communications & Investor Relations

Ms. Allison C. Ambrose J.D.

Senior VP, General Counsel & Secretary

Ms. Lisa Fiering

Senior Vice President of People & Culture

Ms. Mersedeh Miraliakbari Pharm.D.

Senior Vice President of Regulatory Affairs & Quality

FAQs

What is Upstream Bio Inc. share price today?

Upstream Bio Inc. share price today is $7.51 as on at the close of the market. Upstream Bio Inc. share today touched a day high of $7.72 and a low of $7.27.

What is the 52 week high and 52 week low for Upstream Bio Inc. share?

Upstream Bio Inc. share touched a 52 week high of $33.68 on and a 52 week low of $5.85 on . Upstream Bio Inc. stock price today i.e. is closed at $7.51,which is 77.70% down from its 52 week high and 28.38% up from its 52 week low.

What is Upstream Bio Inc.'s market capitalisation today?

Upstream Bio Inc. market capitalisation is $0.00T as on .

How to invest in Upstream Bio Inc. Stock (UPB) from India?

  1. Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
  2. Step 2: Search for Upstream Bio Inc. on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Upstream Bio Inc. Shares that will get you 0.1997 shares as per Upstream Bio Inc. share price of $7.51 per share as on July 3, 2026 at 8:45 am IST.

What is the minimum amount required to buy Upstream Bio Inc. Stock (UPB) from India?

Indian investors can start investing in Upstream Bio Inc. (UPB) shares with as little as ₹95.2 or $1 (as of ) using the INDmoney app.
For example: If you want to invest $10 or ₹952.00 in Upstream Bio Inc. stock (as per the Rupee-Dollar exchange rate as on ). Based on Upstream Bio Inc. share’s latest price of $7.51 as on July 3, 2026 at 8:45 am IST, you will get 1.3316 shares of Upstream Bio Inc.. Learn more about fractional shares .