Spyre Therapeutics Inc Share Price (NASDAQ: SYRE)

Spyre Therapeutics Inc Stock Performance

as on October 4, 2025 at 1:29 am IST

Day's Low
Day's High
$15.92
Day's Price Range
$16.3
$15.89
-0.19%
Downside
2.58%
Upside
52 Week's Low
52 Week's High
$10.91
52-Week Price Range
$40.26
$15.89
31.34%
Downside
153.37%
Upside

Spyre Therapeutics Inc share price movements today

Previous Close: $15.98
Open: $15.99
Volume: 381.7K
Day's Low - High: $15.92 - $16.3
52 Week Low - High: $10.91 - $40.26

Spyre Therapeutics Inc Historical Returns

1 Month Return: -6.47 %
3 Month Return: + 0.82 %
1 Year Return: -45.49 %
3 Year Return: 0 %
5 Year Return: 0 %

Spyre Therapeutics Inc Stock Fundamentals & Key Indicators

Check Spyre Therapeutics Inc market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$965.2M

EPS (TTM)

-2.7796

Dividend Yield

0.00%

Quarterly Earnings Growth YOY

-1.00%

PE Ratio (TTM)

-3.91

Industry PE ratio

P/B Ratio

PEG Ratio

EBITDA

-207.8M

Revenue (TTM)

Profit Margin

0.00%

Return On Equity TTM

0.00%

Spyre Therapeutics Inc Stock Valuation

Track how Spyre Therapeutics Inc P/E has moved over time to understand its valuation trends.

Spyre Therapeutics Inc in the last 5 years

Overview
Trends

Lowest (-8.58x)

September 30, 2025

Industry (0.00x)

October 4, 2025

Today (-3.91x)

October 4, 2025

Highest (-0.24x)

December 31, 2023

LowHigh

Today’s Price to Earnings Ratio: -3.91x

Spyre Therapeutics Inc vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Spyre Therapeutics Inc with its industry peers.

Company	Analyst View	Market Cap	5 Years Return %	PE Ratio	Profit Margin %
Spyre Therapeutics Inc	BUY	$965.2M	NA	-3.91	0.00%
Beone Medicines Ltd	NA	$40.5B	NA	NA	-3.89%
Alnylam Pharmaceuticals, Inc.	BUY	$60.4B	236.34%	-505.15	-12.96%
Vertex Pharmaceuticals Incorporated	BUY	$104.8B	54.64%	29.06	31.86%
Regeneron Pharmaceuticals, Inc.	BUY	$63.6B	6.23%	15.13	31.37%

Stock Returns calculator for Spyre Therapeutics Inc Stock including INR - Dollar returns

The Spyre Therapeutics Inc stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Return is the profit earned when the US dollar rises in value compared to the Indian rupee.

Investment Value

₹1,00,000

Spyre Therapeutics Inc investment value today

Current value as on today

₹60,284

Returns

₹39,716

(-39.72%)

Returns from Spyre Therapeutics Inc Stock

₹45,489 (-45.49%)

Dollar Returns*

₹5,773 (+5.77%)

Analyst Recommendation on Spyre Therapeutics Inc Stock

Based on 13 analysts

BUY

92.31%

Buy

7.69%

Hold

0.00%

Sell

Based on 13 analysts, 92.31% of analysts recommend a 'BUY' rating for Spyre Therapeutics Inc. Average target price of $52.91

Spyre Therapeutics Inc Share Price Target

Get share price movements and forecasts by analysts on Spyre Therapeutics Inc.

What analysts predicted

69.97%UPSIDE

Target Price

$52.91

Current Price

$15.89

Analyzed by

13 Analysts

Target

$52.91

Spyre Therapeutics Inc target price $52.91, a slight upside of 69.97% compared to current price of $15.89. According to 13 analysts rating.

Spyre Therapeutics Inc Stock’s Investor Sentiment and Interest

Search interest for Spyre Therapeutics Inc Stock has decreased by -8% in the last 30 days, reflecting a downward trend in search activity.

Time period: September 5, 2025 to October 5, 2025

Change:-8% versus previous 30 day period

Spyre Therapeutics Inc Quarterly Profit & Loss

All numbers in Millions USD

	Mar 2023	Jun 2023	Sep 2023	Dec 2023	Mar 2024	Jun 2024	Sep 2024	Dec 2024	Mar 2025	Jun 2025
Total Revenue	0	0	-	1	-	-	-	-	-	-
Gross Profit	0	0	-	0	-	-	-	-	-	-
Operating Income	-18	-159	-18	-45	-47	-44	-55	-61	-53	-41
EBITDA	-18	-28	-33	-47	-47	-44	-55	-61	-53	-51
Interest Expense	-	-	-	-	-	-	-	21	-	-
Depreciation	0	0	-	0	-	-	-	-	-	-
Income Before Tax	-18	-217	-40	-63	-43	-38	-69	-56	-44	-36
Income Tax Expense	0	0	0	-5	0	-	0	0	0	-
Net Income	-18	-217	-40	-63	-43	-38	-69	-56	-44	-36
Net Profit Margin	-9304.04%	-31552.47%	0.00%	-6063.34%	0.00%	0.00%	0.00%	0.00%	0.00%	0.00%

Spyre Therapeutics Inc Annual Profit & Loss

All numbers in Millions USD

	Dec 2015	Dec 2016	Dec 2017	Dec 2018	Dec 2019	Dec 2020	Dec 2021	Dec 2022	Dec 2023	Dec 2024
Total Revenue	6	4	5	3	-	-	18	2	0	0
Gross Profit	5	4	5	3	0	-1	18	2	0	0
Operating Income	-11	-21	-27	-45	-80	-81	-65	-84	-242	-208
EBITDA	-11	-21	-27	-45	-77	-80	-64	-82	-242	-207
Interest Expense	-	-	-	-	-	-	-	-	-	-
Depreciation	-	-	-	-	0	0	1	1	0	-
Income Before Tax	-11	-21	-27	-44	-78	-80	-65	-83	-338	-207
Income Tax Expense	-	-	-	-	-	0	0	0	0	0
Net Income	-11	-21	-27	-44	-78	-80	-65	-83	-338	-208
Net Profit Margin	-185.62%	-468.84%	-523.27%	-1140.64%	0.00%	0.00%	-351.14%	-3598.75%	-38238.15%	-23478.33%

Spyre Therapeutics Inc Quarterly Cash Flow

All numbers in Millions USD

	Jun 2023	Sep 2023	Dec 2023	Mar 2024	Jun 2024	Sep 2024	Dec 2024	Mar 2025	Jun 2025
Net Income	-217	-40	-63	-43	-38	-69	-56	-44	-36
Operating Cash Flow	-16	-34	-31	-28	-62	-29	-37	-40	-46
Investing Cash Flow	6	-97	-35	-104	-120	42	-170	0	78
Financing Cash Flow	209	-12	163	172	0	12	225	0	0
Change in Cash	200	-144	97	38	-182	26	17	-40	33

Spyre Therapeutics Inc Annual Cash Flow

All numbers in Millions USD

	Dec 2016	Dec 2017	Dec 2018	Dec 2019	Dec 2020	Dec 2021	Dec 2022	Dec 2023	Dec 2024
Net Income	-21	-27	-44	-78	-80	-65	-83	-338	-208
Operating Cash Flow	-18	-24	-32	-65	-75	-53	-80	-99	-157
Investing Cash Flow	-12	-22	-15	-1	-7	-22	57	-	-353
Financing Cash Flow	49	12	57	65	154	1	42	361	410
Change in Cash	18	-34	9	-3	71	-74	19	152	-99

Insights on Spyre Therapeutics Inc

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

POSITIVE IMPACT
Profit Spike
Netprofit is up for the last 4 quarters, -69.02M → -36.71M (in $), with an average increase of 23.4% per quarter
POSITIVE IMPACT
Revenue Rich
Revenue is up for the last 4 quarters, 168.0K → 1.04M (in $), with an average increase of 40.1% per quarter
POSITIVE IMPACT
Price Rise
In the last 7 days, SYRE stock has moved up by 7.4%
NO EFFECT
Against Peers
In the last 1 year, Alnylam Pharmaceuticals, Inc. has given 67.9% return, outperforming this stock by 107.4%
NO EFFECT
Against Peers
In the last 3 years, Beone Medicines Ltd has given 127.8% return, outperforming this stock by 100.3%

About Spyre Therapeutics Inc

aeglea was founded in december of 2013 to develop engineered human enzymes invented in the laboratory of george georgiou, ph.d. of the university of texas at austin. the convergence of discovery and technology has created a significant opportunity for aeglea to impact both the treatment of inborn errors of metabolism and cancer. three drug candidates that degrade specific amino acids in the circulation are in development. for inborn errors of metabolism efforts are underway to normalize high arginine levels in patients who suffer from a gene mutation in the arginine degrading enzyme arginase1 and for patients who have mutations leading to excess levels of homocysteine. taking advantage of a cancer’s metabolic vulnerability and selectively killing only the tumor through deprivation of arginine, cysteine/cystine, and methionine are techniques in development for multiple oncology indications. coupling amino acid depletion therapy with the development of diagnostics for each oncology f

Organisation	Spyre Therapeutics Inc
Headquarters	221 Crescent Street, Waltham, MA, United States, 02453
CEO	Dr. Cameron Turtle DPHIL, Ph.D.
E-voting on shares	Click here to vote

Key Management of Spyre Therapeutics Inc

Name	Title
Mr. Scott L. Burrows	Chief Financial Officer
Dr. Sheldon Sloan M.B.E., M.D.	Chief Medical Officer
Mr. Brian Connolly	Chief Technical Officer
Ms. Heidy Abreu King-Jones J.D., L.L.M.	Chief Legal Officer & Corporate Secretary
Dr. Cameron Turtle DPHIL, Ph.D.	CEO & Director
Mr. Eric McIntyre	Vice President of Finance & Investor Relations
Mr. James Myers	Vice President of Quality & Compliance
Dr. Justin LaFountaine Ph.D.	Senior Vice President of Corporate Development
Ms. Melissa Cooper	Senior Vice President of People
Dr. Janet Gunzner-Toste M.B.A., Ph.D.	Senior Vice President of Operations

FAQs

What is Spyre Therapeutics Inc share price today?

Spyre Therapeutics Inc share price today is $15.89 as on October 4, 2025 at 1:29 am IST at the close of the market. Spyre Therapeutics Inc share today touched a day high of $16.3 and a low of $15.92.

What is the 52 week high and 52 week low for Spyre Therapeutics Inc share?

Spyre Therapeutics Inc share touched a 52 week high of $40.26 on November 12, 2024 and a 52 week low of $10.91 on April 9, 2025. Spyre Therapeutics Inc stock price today i.e. October 4, 2025 at 1:29 am IST is closed at $15.89,which is 60.53% down from its 52 week high and 45.65% up from its 52 week low.

What is Spyre Therapeutics Inc's market capitalisation today?

Spyre Therapeutics Inc market capitalisation is $0.00T as on October 4, 2025 at 1:29 am IST.

How to invest in Spyre Therapeutics Inc Stock (SYRE) from India?

Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
Step 2: Search for Spyre Therapeutics Inc on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Spyre Therapeutics Inc Shares that will get you 0.0944 shares as per Spyre Therapeutics Inc share price of $15.89 per share as on October 4, 2025 at 1:29 am IST.

What is the minimum amount required to buy Spyre Therapeutics Inc Stock (SYRE) from India?

Indian investors can start investing in Spyre Therapeutics Inc (SYRE) shares with as little as ₹88.775 or $1 (as of October 5, 2025 at 11:37 pm IST) using the INDmoney app.
For example: If you want to invest $10 or ₹887.75 in Spyre Therapeutics Inc stock (as per the Rupee-Dollar exchange rate as on October 5, 2025 at 11:37 pm IST). Based on Spyre Therapeutics Inc share’s latest price of $15.89 as on October 4, 2025 at 1:29 am IST, you will get 0.6293 shares of Spyre Therapeutics Inc. Learn more about fractional shares .