Spyre Therapeutics logo

Spyre Therapeutics Share Price (NASDAQ: SYRE)

$16.1

-0.84

(-4.96%)

Last updated on

Check the interactive Spyre Therapeutics Stock chart to analyse performance

Spyre Therapeutics stock performance

as on August 20, 2025 at 1:29 AM IST

  • Today's Low:$15.91
    Today's High:$16.52

    Day's Volatility :3.69%

  • 52 Weeks Low:$10.91
    52 Weeks High:$40.26

    52 Weeks Volatility :72.9%

Spyre Therapeutics Stock Returns

PeriodSpyre Therapeutics IncIndex (Russel 2000)
3 Months
14.75%
0.0%
6 Months
-24.18%
0.0%
1 Year
-36.46%
0.0%
3 Years
-10.01%
-9.6%

Spyre Therapeutics Inc Key Stats

Check Spyre Therapeutics key stats like market cap, P/E ratio, EPS, Dividend Yield, and more.

Previous Close
$16.94
Open
$16.62
Today's High
$16.52
Today's Low
$15.91
Market Capitalization
$1.0B
Today's Volume
$394.0K
52 Week High
$40.26
52 Week Low
$10.91
Revenue TTM
$0.0
EBITDA
$-207.8M
Earnings Per Share (EPS)
$-2.53
Profit Margin
0.0%
Quarterly Earnings Growth YOY
-1.0%
Return On Equity TTM
-49.83%

Stock Returns calculator for Spyre Therapeutics Stock including INR - Dollar returns

The Spyre Therapeutics stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Return is the profit earned when the US dollar rises in value compared to the Indian rupee.

Investment Value

₹1,00,000

  • 1Y

  • 3Y

  • 5Y

  • 7Y

  • 10Y

Spyre Therapeutics investment value today

Current value as on today

₹61,434

Returns

₹38,566

(-38.57%)

Returns from Spyre Therapeutics Stock

₹42,190 (-42.19%)

Dollar Returns*

₹3,624 (+3.62%)

Indian investors sentiment towards Spyre Therapeutics Stock

71%

Period: Jul 20, 2025 to Aug 19, 2025. Change in 30 Days versus previous period

Search interest for Spyre Therapeutics Stock from India on INDmoney has increased by 71% in the last 30 days, reflecting an upward trend in search activity.

Analyst Recommendation on Spyre Therapeutics Stock

Rating
Trend

Buy

    92%Buy

    7%Hold

    0%Sell

Based on 13 Wall street analysts offering stock ratings for Spyre Therapeutics(by analysts ranked 0 to 5 stars)

Spyre Therapeutics Share Price Target

What analysts predicted

Upside of 240.92%

Target:

$54.89

Current:

$16.10

Spyre Therapeutics share price target is $54.89, a slight Upside of 240.92% compared to current price of $16.10 as per analysts' prediction.

Spyre Therapeutics Stock Insights

  • Price Movement

    In the last 7 days, SYRE stock has moved up by 6.7%
  • Increasing Revenue

    Revenue is up for the last 4 quarters, 168.0K → 1.04M (in $), with an average increase of 40.1% per quarter
  • Increasing Net Profit

    Netprofit is up for the last 4 quarters, -69.02M → -36.71M (in $), with an average increase of 23.4% per quarter
  • SYRE vs ALNY (1 yr)

    In the last 1 year, Alnylam Pharmaceuticals, Inc. has given 66.4% return, outperforming this stock by 105.5%
  • SYRE vs ALNY (3 yr)

    In the last 3 years, Alnylam Pharmaceuticals, Inc. has given 111.5% return, outperforming this stock by 137.0%

Spyre Therapeutics Technicals Summary

Sell

Neutral

Buy

Spyre Therapeutics is currently in a neutral trading position according to technical analysis indicators.

Spyre Therapeutics Inc Vs Peers

Returns
Ratio's
Overview
Company Name1 Month6 Month1 Year3 Years5 Years
Spyre Therapeutics Inc logo
3.73%
-24.18%
-36.46%
-10.01%
-89.58%
Regeneron Pharmaceuticals, Inc. logo
5.3%
-16.22%
-51.82%
-6.15%
-5.13%
Beone Medicines Ltd logo
9.32%
34.83%
64.32%
84.48%
32.68%
Vertex Pharmaceuticals Incorporated logo
-14.97%
-17.36%
-20.01%
32.68%
43.71%
Alnylam Pharmaceuticals, Inc. logo
42.53%
82.36%
62.72%
109.65%
234.44%

About Spyre Therapeutics Inc

Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4ß7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies. In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004; SPY130, a combination of anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. The company was incorporated in 2013 and is based in Waltham, Massachusetts.
Organization
Spyre Therapeutics
Employees
87
CEO
Dr. Cameron Turtle DPHIL, Ph.D.
Industry
Miscellaneous

Key Management of Spyre Therapeutics Inc

NameTitle
Dr. Cameron Turtle DPHIL, Ph.D.
CEO & Director
Mr. Scott L. Burrows
Chief Financial Officer
Dr. Sheldon Sloan M.B.E., M.D.
Chief Medical Officer
Dr. Janet Gunzner-Toste M.B.A., Ph.D.
Senior Vice President of Operations
Mr. Brian Connolly
Chief Technical Officer
Mr. Eric McIntyre
Vice President of Finance & Investor Relations
Ms. Heidy Abreu King-Jones J.D., L.L.M.
Chief Legal Officer & Corporate Secretary
Mr. James Myers
Vice President of Quality & Compliance
Dr. Justin LaFountaine Ph.D.
Senior Vice President of Corporate Development
Ms. Melissa Cooper
Senior Vice President of People

Important FAQs about investing in SYRE Stock from India :

What is Spyre Therapeutics share price today?

Spyre Therapeutics share price today is $16.10 as on at the close of the market. Spyre Therapeutics share today touched a day high of $16.52 and a low of $15.91.

What is the 52 week high and 52 week low for Spyre Therapeutics share?

Spyre Therapeutics share touched a 52 week high of $40.26 and a 52 week low of $10.91. Spyre Therapeutics stock price today i.e. is closed at $16.10, lower by 60.01% versus the 52 week high.

How to invest in Spyre Therapeutics Stock (SYRE) from India?

  1. Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
  2. Step 2: Search for Spyre Therapeutics on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Spyre Therapeutics Shares that will get you 0.0932 shares as per Spyre Therapeutics share price of $16.10 per share as on August 20, 2025 at 1:29 AM IST.

What is the minimum amount required to buy Spyre Therapeutics Stock (SYRE) from India?

Indian investors can start investing in Spyre Therapeutics (SYRE) shares with as little as ₹86.938 or $1 (as of August 20, 2025) using the INDmoney app.
For example: If you want to invest $10 or ₹869.38 in Spyre Therapeutics stock (as per the Rupee-Dollar exchange rate as on August 20, 2025). Based on Spyre Therapeutics share’s latest price of $16.10 as on August 20, 2025 at 1:29 AM IST, you will get 0.6211 shares of Spyre Therapeutics. Learn more about fractional shares .

What are the returns that Spyre Therapeutics has given to Indian investors in the last 5 years?

Spyre Therapeutics stock has given -89.58% share price returns and 16.15% dollar appreciation to an Indian investor in the last 5 years.
Read more about How do Currency Exchange Rates impact your US Stock Investments?