Septerna, Inc. (SEPN) Live Share Price, Invest From India

Septerna, Inc. Stock Performance

as on September 5, 2026 at 3:15 am IST

Day's Low
Day's High
$36.57
Day's Price Range
$37.59
$36.60
0.08%
Downside
2.70%
Upside
52 Week's Low
52 Week's High
$13.67
52-Week Price Range
$51.10
$36.60
62.65%
Downside
39.62%
Upside

Septerna, Inc. share price movements today

Previous Close: $36.80
Open: $36.57
Volume: 67.2K
Market Cap: $1.8B
Day's Low - High: $36.57 - $37.59
52 Week Low - High: $13.67 - $51.10

Septerna, Inc. Historical Returns

1 Month Return: -5.59 %
3 Month Return: + 17.31 %
1 Year Return: + 160.62 %
3 Year Return: 0 %
5 Year Return: 0 %

Septerna, Inc. Stock Fundamentals & Key Indicators

Check Septerna, Inc. market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$1.8B

EPS (TTM)

-0.54

Dividend Yield

0.00%

PE Ratio (TTM)

-83.59

Industry PE ratio

-6.69

PEG Ratio

-0.46420104021453407

Return On Equity TTM

-6.31%

Septerna, Inc. Stock Valuation

Track how Septerna, Inc. P/E has moved over time to understand its valuation trends.

Septerna, Inc. in the last 4 years

Overview
Trends

Lowest (-25.35x)

December 31, 2025

Today (-25.35x)

December 31, 2025

Industry (-6.69x)

December 31, 2025

Highest (99.81x)

December 31, 2023

LowHigh

Today’s Price to Earnings Ratio: -25.35x

Septerna, Inc. vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Septerna, Inc. with its industry peers.

Company	Analyst View	Market Cap	5 Years Return %	PE Ratio	Profit Margin %	Dividend Yield %
Septerna, Inc.	StrongBuy	$1.8B	NA	-83.59	99.57%	NA
Revolution Medicines	BUY	$44.6B	614.61%	NA	0.00%	NA
Vertex Pharmaceuticals	BUY	$141.1B	181.73%	32.21	86.04%	NA
Moderna	BUY	$60.2B	-64.27%	-18.66	-12.57%	NA
Regeneron	BUY	$84.8B	24.12%	20.14	84.86%	0.44%

Stock Returns calculator for Septerna, Inc. Stock including INR - Dollar returns

The Septerna, Inc. stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Impact: The bonus return you make when the US Dollar rises against the Rupee; calculated on the full amount you walk away with, not just what you invested in.

Investment Value

₹1,00,000

Septerna, Inc. investment value today

Current value as on today

₹2,77,700

Returns

₹1,77,700

(+177.7%)

Returns from Septerna, Inc. Stock

₹1,59,207 (+159.21%)

Dollar Impact

₹18,493 (+18.49%)

Analyst Recommendation on Septerna, Inc. Stock

Based on 9 analysts

BUY

100.00%

Buy

0.00%

Hold

0.00%

Sell

Based on 9 analysts, 100% of analysts recommend a 'BUY' rating for Septerna, Inc.. Average target price of $52.88

Indian Investors' Interest in Septerna, Inc. Stock

Search interest for Septerna, Inc. Stock has increased by 197% in the last 30 days, reflecting an upward trend in search activity.

Time period: August 5, 2026 to September 4, 2026

Change:197% versus previous 30 day period

Septerna, Inc. Quarterly Profit & Loss

All numbers in Millions USD

	Dec 2023	Jun 2024	Sep 2024	Dec 2024	Mar 2025	Jun 2025	Sep 2025	Dec 2025	Mar 2026	Jun 2026
Total Revenue	0	0	0	0	0	0	21	24	26	26
Gross Profit	0	0	0	0	0	0	21	24	26	26
Operating Income	34	-18	-22	-24	-25	-28	2	-16	-13	-16
EBITDA	-13	-16	-20	-20	-21	-24	-9	-10	-7	-12
Interest Expense	-	-	-	-	-	-	-	-	-	-
Depreciation	0	0	0	0	0	0	0	0	0	-
Income Before Tax	35	-16	-20	-20	-21	-24	8	-10	-8	-12
Income Tax Expense	0	0	0	0	-	-	-	0	0	0
Net Income	34	-16	-20	-20	-21	-24	8	-10	-8	-13
Net Profit Margin	100.00%	100.00%	100.00%	100.00%	100.00%	100.00%	100.00%	100.00%	98.41%	100.00%

Septerna, Inc. Annual Profit & Loss

All numbers in Millions USD

	Dec 2022	Dec 2023	Dec 2024	Dec 2025
Total Revenue	-	0	1	45
Gross Profit	-	0	1	45
Operating Income	-27	2	-80	-80
EBITDA	-27	-44	-70	-47
Interest Expense	-	-	-	-
Depreciation	0	0	1	1
Income Before Tax	-27	4	-72	-48
Income Tax Expense	-	0	0	0
Net Income	-27	4	-71	-48
Net Profit Margin	0.00%	100.00%	100.00%	100.00%

Septerna, Inc. Quarterly Cash Flow

All numbers in Millions USD

	Dec 2023	Jun 2024	Sep 2024	Dec 2024	Mar 2025	Jun 2025	Sep 2025	Dec 2025	Mar 2026	Jun 2026
Net Income	34	-16	-20	-20	-21	-24	8	-10	-8	-13
Operating Cash Flow	-8	-12	-16	-20	-23	-20	168	-14	-25	-22
Investing Cash Flow	-1	-12	-24	-133	-4	0	-38	-185	-23	18
Financing Cash Flow	-	74	-1	304	0	0	0	1	0	16
Change in Cash	-10	131	-42	149	-28	-20	130	-199	-49	13

Septerna, Inc. Annual Cash Flow

All numbers in Millions USD

	Dec 2022	Dec 2023	Dec 2024	Dec 2025
Net Income	-27	4	-71	-48
Operating Cash Flow	-23	-38	-67	110
Investing Cash Flow	-1	22	-160	-229
Financing Cash Flow	30	74	377	1
Change in Cash	5	57	149	-117

Mutual Funds that own Septerna, Inc. Stock

Check out the Mutual Funds with significant holdings in Septerna, Inc..

Funds	Holdings	Shares Held
VANGUARD INDEX FUNDS	2.497438%	1165728
PRIMECAP Odyssey Funds	1.74172%	812982
Driehaus Mutual Funds	1.417755%	661765
Fidelity Salem Street Trust	0.647525%	302245
Fidelity Concord Street Trust	0.525454%	245266

See all

Global Institutional Holdings in Septerna, Inc.

Funds	Holdings
Peter Kolchinsky	14.99%
Richard Driehaus	9.5%
Vanguard	3.05%
iShares	2.57%
Theofanis Kolokotrones	2.5%

See all

Insights on Septerna, Inc.

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

POSITIVE IMPACT
Price Rise
In the last 1 year, SEPN stock has moved up by 160.6%
NO EFFECT
Against Peers
In the last 1 year, Moderna, Inc. Common Stock has given 513.1% return, outperforming this stock by 352.5%

About Septerna, Inc.

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves' disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women's health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.

Organisation	Septerna, Inc.
Headquarters	250 East Grand Avenue, South San Francisco, CA, United States, 94080
Industry	Biotechnology
CEO	Dr. Jeffrey T. Finer M.D., Ph.D.
E-voting on shares	Click here to vote

Key Management of Septerna, Inc.

Name	Title
Ms. Elizabeth P. Bhatt M.B.A., M.S.	President & COO
Mr. Gilbert M. Labrucherie C.F.A., J.D.	Chief Financial Officer
Dr. Robert J. Lefkowitz M.D.	Co-Founder and Member of Cross-Functional Scientific & Drug Discovery Advisory Board
Dr. Patrick Sexton Ph.D.	Co-Founder and Member of Cross-Functional Scientific & Drug Discovery Advisory Board
Mr. Richard Hansen Ph.D.	Vice President of Technology
Mr. George Xu Ph.D.	Senior Director of Corporate Development & Portfolio Strategy
Ms. Samira Shaikhly	Chief People Officer
Dr. Jeffrey T. Finer M.D., Ph.D.	Co-Founder, CEO & Director
Mr. Mark A. Wilson J.D.	Chief Legal Officer
Dr. Arthur Christopoulos BPHARM, Ph.D.	Co-Founder and Member of Cross-Functional Scientific & Drug Discovery Advisory Board

FAQs

What is Septerna, Inc. share price today?

Septerna, Inc. share price today is $36.60 as on September 4, 2026 at 9:45 pm IST. Septerna, Inc. share today touched a day high of $37.59 and a low of $36.57.

What is the 52 week high and 52 week low for Septerna, Inc. share?

Septerna, Inc. share touched a 52 week high of $51.10 on August 12, 2026 and a 52 week low of $13.67 on September 11, 2025. Septerna, Inc. stock price today i.e. September 4, 2026 at 9:45 pm IST is trending at $36.60,which is 28.38% down from its 52 week high and 167.74% up from its 52 week low.

What is Septerna, Inc.'s market capitalisation today?

Septerna, Inc. market capitalisation is $0.00T as on September 4, 2026 at 9:45 pm IST.

How to invest in Septerna, Inc. Stock (SEPN) from India?

Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
Step 2: Search for Septerna, Inc. on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Septerna, Inc. Shares that will get you 0.0410 shares as per Septerna, Inc. share price of $36.60 per share as on September 4, 2026 at 9:45 pm IST.

What is the minimum amount required to buy Septerna, Inc. Stock (SEPN) from India?

Indian investors can start investing in Septerna, Inc. (SEPN) shares with as little as ₹94.485 or $1 (as of September 4, 2026 at 9:45 pm IST) using the INDmoney app.
For example: If you want to invest $10 or ₹944.85 in Septerna, Inc. stock (as per the Rupee-Dollar exchange rate as on September 4, 2026 at 9:45 pm IST). Based on Septerna, Inc. share’s latest price of $36.60 as on September 4, 2026 at 9:45 pm IST, you will get 0.2732 shares of Septerna, Inc.. Learn more about fractional shares .