Septerna Inc. Share Price (NASDAQ: SEPN)

Septerna Inc. Stock Performance

as on October 17, 2025 at 1:29 am IST

Day's Low
Day's High
$22.37
Day's Price Range
$24
$22.6
1.02%
Downside
6.19%
Upside
52 Week's Low
52 Week's High
$4.17
52-Week Price Range
$28.99
$22.6
81.55%
Downside
28.27%
Upside

Septerna Inc. share price movements today

Previous Close: $23.33
Open: $23.41
Volume: 360.4K
Day's Low - High: $22.37 - $24
52 Week Low - High: $4.17 - $28.99

Septerna Inc. Historical Returns

1 Month Return: + 56.81 %
3 Month Return: + 78.8 %
1 Year Return: 0 %
3 Year Return: 0 %
5 Year Return: 0 %

Septerna Inc. Stock Fundamentals & Key Indicators

Check Septerna Inc. market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$1.0B

EPS (TTM)

-0.3513

Dividend Yield

0.00%

PE Ratio (TTM)

PEG Ratio

Return On Equity TTM

37618500.00%

Septerna Inc. vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Septerna Inc. with its industry peers.

Company	Analyst View	Market Cap	5 Years Return %	PE Ratio	Profit Margin %
Septerna Inc.	NA	$1.0B	NA	NA	0.00%
Alnylam Pharmaceuticals, Inc.	BUY	$61.6B	230.86%	-505.15	-12.96%
Beone Medicines Ltd	NA	$35.8B	NA	NA	-3.89%
Vertex Pharmaceuticals Incorporated	BUY	$104.6B	87.37%	29.01	31.86%
Regeneron Pharmaceuticals, Inc.	BUY	$61.1B	-5.1%	14.53	31.37%

Septerna Inc. Quarterly Profit & Loss

All numbers in Millions USD

	Sep 2023	Dec 2023	Mar 2024	Jun 2024	Sep 2024	Dec 2024	Mar 2025	Jun 2025
Total Revenue	0	0	0	0	0	0	0	0
Gross Profit	0	0	0	0	0	0	0	0
Operating Income	-12	34	-15	-18	-22	-24	-25	-28
EBITDA	-11	-13	-15	-17	-22	-24	-25	-28
Interest Expense	-	-	-	-	-	-	-	-
Depreciation	0	0	0	0	0	0	0	0
Income Before Tax	-10	35	-14	-16	-20	-20	-21	-24
Income Tax Expense	-	0	0	0	0	0	-	-
Net Income	-10	34	-14	-16	-20	-20	-21	-24
Net Profit Margin	-33166.67%	29571.19%	-4468.77%	-4443.51%	-11660.80%	-9749.06%	-9806.39%	-20872.27%

Septerna Inc. Annual Profit & Loss

All numbers in Millions USD

	Dec 2022	Dec 2023	Dec 2024
Total Revenue	-	0	1
Gross Profit	-	0	1
Operating Income	-27	2	-80
EBITDA	-27	-44	-79
Interest Expense	-	-	-
Depreciation	0	0	1
Income Before Tax	-27	4	-72
Income Tax Expense	-	0	0
Net Income	-27	4	-71
Net Profit Margin	0.00%	2768.21%	-6678.88%

Septerna Inc. Quarterly Cash Flow

All numbers in Millions USD

	Dec 2023	Mar 2024	Jun 2024	Sep 2024	Dec 2024	Mar 2025	Jun 2025
Net Income	34	-14	-16	-20	-20	-21	-24
Operating Cash Flow	-8	-16	-12	-16	-20	-23	-20
Investing Cash Flow	-1	9	-12	-24	-133	-4	0
Financing Cash Flow	-	-	74	-1	304	0	0
Change in Cash	-10	-7	49	-42	149	-28	-20

Septerna Inc. Annual Cash Flow

All numbers in Millions USD

	Dec 2023	Dec 2024
Net Income	4	-71
Operating Cash Flow	-38	-67
Investing Cash Flow	22	-160
Financing Cash Flow	74	377
Change in Cash	57	149

Insights on Septerna Inc.

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

POSITIVE IMPACT
Price Rise
In the last 1 month, SEPN stock has moved up by 56.8%

About Septerna Inc.

Septerna, Inc. is a clinical-stage biotechnology company. The Company is developing G protein-coupled receptor (GPCR) oral small-molecule drug discovery powered by its proprietary Native Complex Platform. Its pipeline of product candidates is focused on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. Its industrial-scale Native Complex Platform is designed to target certain GPCRs for the first time, uncover novel binding pockets for validated receptors, and pursue a wide spectrum of pharmacologies, including agonists, antagonists, and allosteric modulators, to achieve desired therapeutic effects. It is advancing a deep portfolio of oral small molecule GPCR-targeted programs with novel mechanistic approaches to treat diseases across multiple therapeutic areas for patients with unmet needs. It is focused on therapeutic areas, such as neurology, women’s health, cardiovascular, and respiratory disease.

Organisation	Septerna Inc.
Headquarters	250 East Grand Avenue, South San Francisco, CA, United States, 94080
CEO	Dr. Jeffrey T. Finer M.D., Ph.D.
E-voting on shares	Click here to vote

Key Management of Septerna Inc.

Name	Title
Dr. Arthur Christopoulos BPHARM, Ph.D.	Co-Founder and Member of Cross-Functional Scientific & Drug Discovery Advisory Board
Dr. Patrick Sexton Ph.D.	Co-Founder and Member of Cross-Functional Scientific & Drug Discovery Advisory Board
Mr. Gilbert M. Labrucherie C.F.A., J.D.	Chief Financial Officer
Ms. Elizabeth P. Bhatt M.B.A., M.S.	President & COO
Dr. Jae B. Kim FACC, M.D.	Chief Medical Officer
Mr. Richard Hansen Ph.D.	Vice President of Technology
Mr. George Xu Ph.D.	Senior Director of Corporate Development & Portfolio Strategy
Ms. Samira Shaikhly	Chief People Officer
Dr. Jeffrey T. Finer M.D., Ph.D.	Co-Founder, CEO & Director
Dr. Robert J. Lefkowitz M.D.	Co-Founder and Member of Cross-Functional Scientific & Drug Discovery Advisory Board

FAQs

What is Septerna Inc. share price today?

Septerna Inc. share price today is $22.6 as on October 17, 2025 at 1:29 am IST at the close of the market. Septerna Inc. share today touched a day high of $24 and a low of $22.37.

What is the 52 week high and 52 week low for Septerna Inc. share?

Septerna Inc. share touched a 52 week high of $28.99 on December 23, 2024 and a 52 week low of $4.17 on February 18, 2025. Septerna Inc. stock price today i.e. October 17, 2025 at 1:29 am IST is closed at $22.6,which is 22.04% down from its 52 week high and 441.97% up from its 52 week low.

What is Septerna Inc.'s market capitalisation today?

Septerna Inc. market capitalisation is $0.00T as on October 17, 2025 at 1:29 am IST.

How to invest in Septerna Inc. Stock (SEPN) from India?

Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
Step 2: Search for Septerna Inc. on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Septerna Inc. Shares that will get you 0.0664 shares as per Septerna Inc. share price of $22.6 per share as on October 17, 2025 at 1:29 am IST.

What is the minimum amount required to buy Septerna Inc. Stock (SEPN) from India?

Indian investors can start investing in Septerna Inc. (SEPN) shares with as little as ₹87.83 or $1 (as of October 17, 2025 at 1:39 pm IST) using the INDmoney app.
For example: If you want to invest $10 or ₹878.30 in Septerna Inc. stock (as per the Rupee-Dollar exchange rate as on October 17, 2025 at 1:39 pm IST). Based on Septerna Inc. share’s latest price of $22.6 as on October 17, 2025 at 1:29 am IST, you will get 0.4425 shares of Septerna Inc.. Learn more about fractional shares .