Ionis Pharmaceuticals, Inc. share price logo

Ionis Pharmaceuticals, Inc. Share Price

NASDAQ: IONS

Large Cap

$79.17

-2.79

(-3.40%)

Live

as on

Ionis Pharmaceuticals, Inc. Stock Performance

as on March 4, 2026 at 6:08 am IST

  • Day's Low

    Day's High

    $78.51
    $81.40
    downward going graph

    0.83%

    Downside

    2.82%

    Upside

    downward going graph
  • 52 Week's Low

    52 Week's High

    $23.95
    $86.74
    downward going graph

    69.75%

    Downside

    9.56%

    Upside

    downward going graph

Ionis Pharmaceuticals, Inc. share price movements today

Previous Close
$81.96
Open
$80.50
Volume
926.2K
Day's Low - High
$78.51 - $81.40
52 Week Low - High
$23.95 - $86.74

Ionis Pharmaceuticals, Inc. Historical Returns

1 Month Return
-3.11 %
3 Month Return
+ 0.15 %
1 Year Return
+ 151.41 %
3 Year Return
+ 123.93 %
5 Year Return
+ 55.17 %

Ionis Pharmaceuticals, Inc. Stock Fundamentals & Key Indicators

Check Ionis Pharmaceuticals, Inc. market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$13.1B

EPS (TTM)

-3.2429

Dividend Yield

0.00%

Quarterly Earnings Growth YOY

-0.44%

PE Ratio (TTM)

-19.95

Industry PE ratio

8.581171171171171

PEG Ratio

25.7033

EBITDA

-369.2M

Revenue (TTM)

943.7M

Profit Margin

-40.41%

Return On Equity TTM

-70.80%

Ionis Pharmaceuticals, Inc. Stock Valuation

Track how Ionis Pharmaceuticals, Inc. P/E has moved over time to understand its valuation trends.

Ionis Pharmaceuticals, Inc. in the last 5 years

  • Overview

  • Trends

Lowest (-163.66x)

March 31, 2022

Today (-19.95x)

March 3, 2026

Industry (8.58x)

March 3, 2026

Highest (-10.69x)

September 30, 2023

LowHigh

Today’s Price to Earnings Ratio: -19.95x

Ionis Pharmaceuticals, Inc. vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Ionis Pharmaceuticals, Inc. with its industry peers.

Company
Analyst View
Market Cap
5 Years Return %PE RatioProfit Margin %
BUY$13.1B55.17%-19.95-40.41%
BUY$126.2B133.18%32.4732.94%
BUY$44.2B125.24%142.888.45%
NA$35.1BNA621.555.37%
BUY$82.6B77.02%18.8331.41%

Stock Returns calculator for Ionis Pharmaceuticals, Inc. Stock including INR - Dollar returns

The Ionis Pharmaceuticals, Inc. stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Return is the profit earned when the US dollar rises in value compared to the Indian rupee.

Investment Value

₹1,00,000

  • 1Y

  • 3Y

  • 5Y

  • 7Y

  • 10Y

Ionis Pharmaceuticals, Inc. investment value today

Current value as on today

₹2,48,358

Returns

₹1,48,358

(+148.36%)

Returns from Ionis Pharmaceuticals, Inc. Stock

₹1,42,853 (+142.85%)

Dollar Returns*

₹5,505 (+5.5%)

Analyst Recommendation on Ionis Pharmaceuticals, Inc. Stock

Based on 30 analysts

BUY

66.67%

Buy

23.33%

Hold

10.00%

Sell

Based on 30 analysts, 66.67% of analysts recommend a 'BUY' rating for Ionis Pharmaceuticals, Inc.. Average target price of $93.81

Ionis Pharmaceuticals, Inc. Share Price Target

Get share price movements and forecasts by analysts on Ionis Pharmaceuticals, Inc..

What analysts predicted

15.61%UPSIDE

Target Price

$93.81

Current Price

$79.17

Analyzed by

30 Analysts

Target

$93.81

Ionis Pharmaceuticals, Inc. target price $93.81, a slight upside of 15.61% compared to current price of $79.17. According to 30 analysts rating.

Ionis Pharmaceuticals, Inc. Stock’s Investor Sentiment and Interest

Search interest for Ionis Pharmaceuticals, Inc. Stock has decreased by -54% in the last 30 days, reflecting a downward trend in search activity.

Time period: to

Change:-54% versus previous 30 day period

Ionis Pharmaceuticals, Inc. Quarterly Profit & Loss

All numbers in Millions USD

Sep 2023
Dec 2023
Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Total Revenue
144
119
119
225
133
226
131
452
156
203
Gross Profit
142
117
117
221
132
222
130
447
154
195
Operating Income
-143
-149
-149
-66
-148
-110
-146
139
-160
-215
EBITDA
-114
-116
-116
-37
-117
-80
-120
150
-103
4,607
Interest Expense
21
22
22
22
22
22
22
22
22
18
Depreciation
5
5
5
5
5
5
5
5
4
-
Income Before Tax
-140
-142
-142
-66
-144
-107
-146
123
-128
-228
Income Tax Expense
6
0
0
0
-3
-2
0
0
0
1
Net Income
-147
-142
-142
-66
-140
-104
-146
123
-128
-229
Net Profit Margin
-102.22%
-119.50%
-119.50%
-29.42%
-104.98%
-46.05%
-111.64%
27.33%
-82.06%
-112.81%

Ionis Pharmaceuticals, Inc. Annual Profit & Loss

All numbers in Millions USD

Dec 2016
Dec 2017
Dec 2018
Dec 2019
Dec 2020
Dec 2021
Dec 2022
Dec 2023
Dec 2024
Dec 2025
Total Revenue
346
514
599
1,123
729
810
587
787
705
944
Gross Profit
2
514
597
1,119
717
799
573
778
693
928
Operating Income
-46
31
-61
366
-172
-30
-410
-353
-475
-382
EBITDA
-37
36
-18
381
-154
-5
-227
-235
-353
-286
Interest Expense
38
44
44
49
44
9
8
81
90
73
Depreciation
-
8
12
15
17
19
22
22
21
-
Income Before Tax
-83
-16
-76
347
-170
-29
-257
-333
-460
-380
Income Tax Expense
2
-5
-291
44
317
0
11
32
-6
1
Net Income
-86
0
273
294
-487
-28
-269
-366
-453
-381
Net Profit Margin
-24.97%
0.07%
45.65%
26.18%
-66.80%
-3.53%
-45.92%
-46.50%
-64.37%
-40.36%

Ionis Pharmaceuticals, Inc. Quarterly Cash Flow

All numbers in Millions USD

Dec 2023
Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Net Income
-142
-142
-66
-140
-104
-146
123
-128
146,561
Operating Cash Flow
-149
-149
-119
-114
-116
-150
151
-131
150,486
Investing Cash Flow
76
76
62
-340
68
170
-120
91
-170,708
Financing Cash Flow
23
23
2
496
-44
2
1
81
-1,605
Change in Cash
-50
-50
-54
40
-92
22
33
41
33

Ionis Pharmaceuticals, Inc. Annual Cash Flow

All numbers in Millions USD

Dec 2017
Dec 2018
Dec 2019
Dec 2020
Dec 2021
Dec 2022
Dec 2023
Dec 2024
Dec 2025
Net Income
-17
214
303
-486
-28
-269
-366
-453
-381
Operating Cash Flow
174
602
345
35
30
-274
-307
-500
-268
Investing Cash Flow
-358
-929
-41
274
194
-262
-214
-134
-277
Financing Cash Flow
229
475
100
-596
245
-55
644
478
675
Change in Cash
44
149
404
-285
471
-592
122
-157
130

Global Institutional Holdings in Ionis Pharmaceuticals, Inc.

Funds
Holdings
T. Rowe Price Investment Management,Inc.
8.12%
Millennium Management LLC
1.66%
Two Sigma Investments LLC
1.12%
BlackRock Inc
6.45%
American Century Companies Inc
1%

Ionis Pharmaceuticals, Inc. News & Key Events

  • img

    Today's Timeline - 08 October

    Wed, 05:57 PM

    -

    JPMorgan upgrades Ionis Pharmaceuticals to overweight, raising price target to $80, citing strong drug pipeline and potential for breakeven.

Insights on Ionis Pharmaceuticals, Inc.

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

  • imgPOSITIVE IMPACT

    Best in 3 Years

    img

    In the last 3 years, IONS has outperformed top 5 stocks with highest market-cap in its industry

  • imgPOSITIVE IMPACT

    Best in 1 Year

    img

    In the last 1 year, IONS has outperformed top 5 stocks with highest market-cap in its industry

  • imgPOSITIVE IMPACT

    Price Rise

    img

    In the last 1 year, IONS stock has moved up by 151.4%

  • imgPOSITIVE IMPACT

    Revenue Rich

    img

    Revenue is up for the last 2 quarters, 156.71M → 203.0M (in $), with an average increase of 22.8% per quarter

  • imgNEGATIVE IMPACT

    Profit Down

    img

    Netprofit is down for the last 3 quarters, 123.55M → -229.0M (in $), with an average decrease of 141.1% per quarter

About Ionis Pharmaceuticals, Inc.

ionis pharmaceuticals, inc., located in the north san diego county city of carlsbad, was founded in 1989 to create advanced, novel medicines to treat complex and challenging diseases. we are the pioneer in the discovery and development of antisense drugs with more than 1300 patents. ionis is a challenging, motivating and rewarding environment designed to foster innovation and scientific excellence. our founding goals have changed little in over 27 years and our success is a direct result of our outstanding employees. we are interested in bringing together individuals with different skill sets into this creative environment to be part of a productive team. join us and experience our unique culture while you develop and expand your career. for more information about ionis and to apply for an open position, please visit our website: www.ionispharma.com.
OrganisationIonis Pharmaceuticals, Inc.
Headquarters2855 Gazelle Court, Carlsbad, CA, United States, 92010
IndustryHealth Technology
CEODr. Brett P. Monia Ph.D.
E-voting on sharesClick here to vote

Key Management of Ionis Pharmaceuticals, Inc.

Name

Title

Mr. Charles G. Asare M.D., M.P.H.

VP & Head of Drug Safety

Mr. Brian Birchler

Executive Vice President of Corporate & Development Operations

Dr. Sotirios Tsimikas M.D.

Senior Vice President of Global Cardiovascular Development

Dr. Brett P. Monia Ph.D.

Founder, CEO & Director

Ms. Elizabeth L. Hougen M.A., M.B.A., M.S.

Executive VP of Finance & CFO

Dr. Richard S. Geary Ph.D.

Strategic Consultant

Dr. Holly Kordasiewicz Ph.D.

Executive VP & Chief Development Officer

Dr. Eric E. Swayze Ph.D.

Executive Vice President of Research

Mr. Patrick R. O'Neil Esq.

Executive VP, Chief Legal Officer, General Counsel & Corporate Secretary

Mr. Kyle Jenne

Executive VP & Chief Global Product Strategy Officer

FAQs

What is Ionis Pharmaceuticals, Inc. share price today?

Ionis Pharmaceuticals, Inc. share price today is $79.17 as on . Ionis Pharmaceuticals, Inc. share today touched a day high of $81.4 and a low of $78.51.

What is the 52 week high and 52 week low for Ionis Pharmaceuticals, Inc. share?

Ionis Pharmaceuticals, Inc. share touched a 52 week high of $86.74 on and a 52 week low of $23.95 on . Ionis Pharmaceuticals, Inc. stock price today i.e. is trending at $79.17,which is 8.73% down from its 52 week high and 230.56% up from its 52 week low.

What is Ionis Pharmaceuticals, Inc.'s market capitalisation today?

Ionis Pharmaceuticals, Inc. market capitalisation is $0.01T as on .

How to invest in Ionis Pharmaceuticals, Inc. Stock (IONS) from India?

  1. Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
  2. Step 2: Search for Ionis Pharmaceuticals, Inc. on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Ionis Pharmaceuticals, Inc. Shares that will get you 0.0189 shares as per Ionis Pharmaceuticals, Inc. share price of $79.17 per share as on March 4, 2026 at 12:38 am IST.

What is the minimum amount required to buy Ionis Pharmaceuticals, Inc. Stock (IONS) from India?

Indian investors can start investing in Ionis Pharmaceuticals, Inc. (IONS) shares with as little as ₹92.074 or $1 (as of ) using the INDmoney app.
For example: If you want to invest $10 or ₹920.74 in Ionis Pharmaceuticals, Inc. stock (as per the Rupee-Dollar exchange rate as on ). Based on Ionis Pharmaceuticals, Inc. share’s latest price of $79.17 as on March 4, 2026 at 12:38 am IST, you will get 0.1263 shares of Ionis Pharmaceuticals, Inc.. Learn more about fractional shares .

What are the returns that Ionis Pharmaceuticals, Inc. has given to Indian investors in the last 5 years?

Ionis Pharmaceuticals, Inc. stock has given 55.17% share price returns and 25.56% dollar appreciation to an Indian investor in the last 5 years.
Read more about How do Currency Exchange Rates impact your returns on US Stock Investments?