Denali Therapeutics Inc share price logo

Denali Therapeutics Inc Share Price

NASDAQ: DNLI

Mid Cap

$13.50

+0.34

(+2.58%)

Live

as on

Denali Therapeutics Inc Stock Performance

as on September 16, 2025 at 11:41 pm IST

  • Day's Low

    Day's High

    $13.13
    $13.58
    downward going graph

    2.74%

    Downside

    0.59%

    Upside

    downward going graph
  • 52 Week's Low

    52 Week's High

    $10.57
    $33.33
    downward going graph

    21.70%

    Downside

    146.89%

    Upside

    downward going graph

Denali Therapeutics Inc share price movements today

Previous Close
$13.16
Open
$13.14
Volume
1.4M
Day's Low - High
$13.13 - $13.58
52 Week Low - High
$10.57 - $33.33

Denali Therapeutics Inc Historical Returns

1 Month Return
-10.48 %
3 Month Return
-9.99 %
1 Year Return
-56.61 %
3 Year Return
-55.88 %
5 Year Return
-65.59 %

Denali Therapeutics Inc Stock Fundamentals & Key Indicators

Check Denali Therapeutics Inc market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$1.9B

EPS (TTM)

-3.0051

Dividend Yield

0.00%

Quarterly Earnings Growth YOY

0.00%

PE Ratio (TTM)

-8.32

Industry PE ratio

10.127857142857144

P/B Ratio

0

PEG Ratio

0

EBITDA

-529.4M

Revenue (TTM)

-

Profit Margin

0.00%

Return On Equity TTM

12350800.00%

Denali Therapeutics Inc Stock Valuation

Track how Denali Therapeutics Inc P/E has moved over time to understand its valuation trends.

Denali Therapeutics Inc in the last 5 years

  • Overview

  • Trends

Lowest (0.00x)

September 16, 2025

Today (-8.32x)

September 16, 2025

Industry (10.13x)

September 16, 2025

Highest (0.00x)

September 16, 2025

LowHigh

Today’s Price to Earnings Ratio: -8.32x

Denali Therapeutics Inc vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Denali Therapeutics Inc with its industry peers.

Company
Analyst View
Market Cap
5 Years Return %PE RatioProfit Margin %
BUY$1.9B-65.59%-8.320.00%
BUY$61.1B251.26%-505.15-12.96%
NA$38.7BNANA-3.89%
BUY$101.2B47.46%28.0931.86%
BUY$59.6B0.6%14.131.37%

Stock Returns calculator for Denali Therapeutics Inc Stock including INR - Dollar returns

The Denali Therapeutics Inc stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Return is the profit earned when the US dollar rises in value compared to the Indian rupee.

Investment Value

₹1,00,000

  • 1Y

  • 3Y

  • 5Y

  • 7Y

Denali Therapeutics Inc investment value today

Current value as on today

₹49,378

Returns

₹50,622

(-50.62%)

Returns from Denali Therapeutics Inc Stock

₹55,490 (-55.49%)

Dollar Returns*

₹4,867 (+4.87%)

Analyst Recommendation on Denali Therapeutics Inc Stock

Based on 23 analysts

BUY

86.96%

Buy

13.04%

Hold

0.00%

Sell

Based on 23 analysts, 86.96% of analysts recommend a 'BUY' rating for Denali Therapeutics Inc. Average target price of $31.5

Denali Therapeutics Inc Share Price Target

Get share price movements and forecasts by analysts on Denali Therapeutics Inc.

What analysts predicted

57.14%UPSIDE

Target Price

$31.5

Current Price

$13.5

Analyzed by

23 Analysts

Target

$31.50

Denali Therapeutics Inc target price $31.5, a slight upside of 57.14% compared to current price of $13.5. According to 23 analysts rating.

Denali Therapeutics Inc Stock's Interest Amongst Investors

Search interest for Denali Therapeutics Inc Stock has increased by 4% in the last 30 days, reflecting an upward trend in search activity.

Time period: to

Change:4% versus previous 30 day period

Denali Therapeutics Inc Quarterly Profit & Loss

All numbers in Millions USD

Mar 2023
Jun 2023
Sep 2023
Dec 2023
Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Total Revenue
35
294
1
-305
-
-
-
-
-
-
Gross Profit
25
292
0
-307
-2
-1
-
-
-
-3
Operating Income
-120
170
-113
-132
-132
-116
-123
-129
-145
-134
EBITDA
-110
170
-111
-130
-130
-114
-120
-127
-142
-121
Interest Expense
21
-
-
21
-
-
-
-
-
-
Depreciation
10
2
2
2
2
1
2
2
3
3
Income Before Tax
-109
183
-99
-119
-101
-99
-107
-114
-132
-124
Income Tax Expense
-10
-2
2
0
2
-
-
0
-
-
Net Income
-109
183
-99
-119
-101
-99
-107
-114
-132
-124
Net Profit Margin
-312.40%
62.35%
-7841.59%
39.17%
0.00%
0.00%
0.00%
0.00%
0.00%
0.00%

Denali Therapeutics Inc Annual Profit & Loss

All numbers in Millions USD

Dec 2015
Dec 2016
Dec 2017
Dec 2018
Dec 2019
Dec 2020
Dec 2021
Dec 2022
Dec 2023
Dec 2024
Total Revenue
-
-
-
129
26
335
48
108
330
-
Gross Profit
0
-1
-74
129
26
335
48
101
313
-
Operating Income
-16
-87
-90
-46
-213
62
-295
-340
-196
-487
EBITDA
-15
-85
-87
-38
-205
71
-287
-330
-179
-414
Interest Expense
0
-
1
1
15
17
13
14
-
-
Depreciation
-
-
3
7
7
8
8
10
18
8
Income Before Tax
-16
-86
-88
-36
-197
71
-291
-325
-145
-422
Income Tax Expense
-
-
-3
10
0
0
0
0
0
0
Net Income
-16
-86
-88
-36
-197
71
-290
-325
-145
-422
Net Profit Margin
0.00%
0.00%
0.00%
-28.06%
-740.74%
21.19%
-597.15%
-300.56%
-43.94%
0.00%

Denali Therapeutics Inc Quarterly Cash Flow

All numbers in Millions USD

Jun 2023
Sep 2023
Dec 2023
Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Net Income
183
-99
-119
-101
-99
-107
-114
-132
-124
Operating Cash Flow
-113
-87
-98
-113
-91
-59
-83
-131
-75
Investing Cash Flow
168
100
73
-453
98
93
172
18
157
Financing Cash Flow
9
2
4
500
6
-18
-4
-3
1
Change in Cash
63
16
-20
-66
14
15
84
-116
84

Denali Therapeutics Inc Annual Cash Flow

All numbers in Millions USD

Dec 2016
Dec 2017
Dec 2018
Dec 2019
Dec 2020
Dec 2021
Dec 2022
Dec 2023
Dec 2024
Net Income
-86
-88
-36
-197
71
-290
-325
-145
-422
Operating Cash Flow
-72
-76
50
-151
416
-211
-244
-357
-347
Investing Cash Flow
-219
-41
-287
147
-623
-21
-141
249
-88
Financing Cash Flow
300
296
97
6
634
19
310
17
484
Change in Cash
9
178
-140
2
427
-213
-75
-90
47

Global Institutional Holdings in Denali Therapeutics Inc

Funds
Holdings
BlackRock Inc
9.52%
Baillie Gifford & Co Limited.
8.23%
Vanguard Group Inc
8.12%
Wellington Management Company LLP
7.85%
FMR Inc
5.1%

Insights on Denali Therapeutics Inc

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

  • imgPOSITIVE IMPACT

    Profit Spike

    img

    Netprofit is up for the last 2 quarters, -132.97M → -124.11M (in $), with an average increase of 7.1% per quarter

  • imgNO EFFECT

    Against Peers

    img

    In the last 3 years, Alnylam Pharmaceuticals, Inc. has given 116.5% return, outperforming this stock by 172.4%

  • imgNO EFFECT

    Against Peers

    img

    In the last 1 year, Alnylam Pharmaceuticals, Inc. has given 70.6% return, outperforming this stock by 127.2%

  • imgNEGATIVE IMPACT

    Revenue Fall

    img

    Revenue is down for the last 3 quarters, 294.12M → -305.04M (in $), with an average decrease of 12137.8% per quarter

  • imgNEGATIVE IMPACT

    Price Dip

    img

    In the last 7 days, DNLI stock has moved down by -14.3%

About Denali Therapeutics Inc

denali therapeutics inc. (“denali”) is a biotechnology company focused on the discovery and development of therapies for patients with neurodegenerative diseases, including alzheimer’s disease, parkinson’s disease, als and others. denali was founded by scientists, industry experts and investors who share the vision that recent scientific insights into the genetic causes and biological processes underlying neurodegenerative disease, together with new translational medicine tools, offer an unprecedented opportunity to discover and develop effective medicines. denali is rigorously pursuing a science-driven approach to translational medicine and clinical development. founding investors include fidelity biosciences, arch venture partners, flagship ventures and the alaska permanent fund (represented by crestline investors).
OrganisationDenali Therapeutics Inc
Headquarters161 Oyster Point Boulevard, South San Francisco, CA, United States, 94080
IndustryHealth Technology
CEODr. Ryan J. Watts Ph.D.
E-voting on sharesClick here to vote

Key Management of Denali Therapeutics Inc

Name

Title

Dr. Ryan J. Watts Ph.D.

Co-Founder, President, CEO & Director

Dr. Alexander O. Schuth M.D.

Co-Founder, CFO, COO & Secretary

Dr. Carole Ho M.D.

Chief Medical Officer & Head of Development

Dr. Dana Andersen

Chief Technical and Manufacturing Officer

Mr. Joe Lewcock Ph.D.

Chief Scientific Officer

Mr. Chris Walsh J.D.

General Counsel

Ms. Cindy Dunkle

Chief People Officer

Ms. Katie Peng

Chief Commercial Officer

FAQs

What is Denali Therapeutics Inc share price today?

Denali Therapeutics Inc share price today is $13.5 as on . Denali Therapeutics Inc share today touched a day high of $13.58 and a low of $13.13.

What is the 52 week high and 52 week low for Denali Therapeutics Inc share?

Denali Therapeutics Inc share touched a 52 week high of $33.33 on and a 52 week low of $10.57 on . Denali Therapeutics Inc stock price today i.e. is trending at $13.5,which is 59.50% down from its 52 week high and 27.72% up from its 52 week low.

What is Denali Therapeutics Inc's market capitalisation today?

Denali Therapeutics Inc market capitalisation is $0.00T as on .

How to invest in Denali Therapeutics Inc Stock (DNLI) from India?

  1. Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
  2. Step 2: Search for Denali Therapeutics Inc on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Denali Therapeutics Inc Shares that will get you 0.1111 shares as per Denali Therapeutics Inc share price of $13.5 per share as on September 16, 2025 at 11:41 pm IST.

What is the minimum amount required to buy Denali Therapeutics Inc Stock (DNLI) from India?

Indian investors can start investing in Denali Therapeutics Inc (DNLI) shares with as little as ₹88.042 or $1 (as of ) using the INDmoney app.
For example: If you want to invest $10 or ₹880.42 in Denali Therapeutics Inc stock (as per the Rupee-Dollar exchange rate as on ). Based on Denali Therapeutics Inc share’s latest price of $13.5 as on September 16, 2025 at 11:41 pm IST, you will get 0.7407 shares of Denali Therapeutics Inc. Learn more about fractional shares .

What are the returns that Denali Therapeutics Inc has given to Indian investors in the last 5 years?

Denali Therapeutics Inc stock has given -65.59% share price returns and 20.01% dollar appreciation to an Indian investor in the last 5 years.
Read more about How do Currency Exchange Rates impact your returns on US Stock Investments?