Silence Therapeutics Plc Share Price

NASDAQ: SLN

Small Cap

$4.71

+0.20

(+4.43%)

as on September 16, 2025 at 1:29 am IST

$₹

Silence Therapeutics Plc Stock Performance

as on September 16, 2025 at 1:29 am IST

Day's Low
Day's High
$4.42
Day's Price Range
$4.73
$4.71
6.16%
Downside
0.42%
Upside
52 Week's Low
52 Week's High
$1.97
52-Week Price Range
$20.48
$4.71
58.17%
Downside
334.82%
Upside

Silence Therapeutics Plc share price movements today

Previous Close: $4.51
Open: $4.53
Volume: 279.6K
Day's Low - High: $4.42 - $4.73
52 Week Low - High: $1.97 - $20.48

Silence Therapeutics Plc Historical Returns

1 Month Return: -17.78 %
3 Month Return: -10.87 %
1 Year Return: -75.26 %
3 Year Return: -61.09 %
5 Year Return: 0 %

Silence Therapeutics Plc Stock Fundamentals & Key Indicators

Check Silence Therapeutics Plc market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$226.7M

EPS (TTM)

-1.21

Dividend Yield

0.00%

Quarterly Earnings Growth YOY

0.00%

PE Ratio (TTM)

P/B Ratio

PEG Ratio

EBITDA

-71.3M

Revenue (TTM)

27.2M

Profit Margin

-291.24%

Return On Equity TTM

778000.00%

Silence Therapeutics Plc vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Silence Therapeutics Plc with its industry peers.

Company	Analyst View	Market Cap	5 Years Return %	PE Ratio	Profit Margin %
Silence Therapeutics Plc	BUY	$226.7M	NA	NA	-291.24%
Alnylam Pharmaceuticals, Inc.	BUY	$61.1B	251.26%	-505.15	-12.96%
Beone Medicines Ltd	NA	$38.7B	NA	NA	-3.89%
Vertex Pharmaceuticals Incorporated	BUY	$101.2B	47.46%	28.09	31.86%
Regeneron Pharmaceuticals, Inc.	BUY	$59.6B	0.6%	14.1	31.37%

Stock Returns calculator for Silence Therapeutics Plc Stock including INR - Dollar returns

The Silence Therapeutics Plc stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Return is the profit earned when the US dollar rises in value compared to the Indian rupee.

Investment Value

₹1,00,000

Silence Therapeutics Plc investment value today

Current value as on today

₹30,704

Returns

₹69,296

(-69.3%)

Returns from Silence Therapeutics Plc Stock

₹74,163 (-74.16%)

Dollar Returns*

₹4,867 (+4.87%)

Analyst Recommendation on Silence Therapeutics Plc Stock

Based on 3 analysts

BUY

100.00%

Buy

0.00%

Hold

0.00%

Sell

Based on 3 analysts, 100% of analysts recommend a 'BUY' rating for Silence Therapeutics Plc. Average target price of $33.94

Silence Therapeutics Plc Share Price Target

Get share price movements and forecasts by analysts on Silence Therapeutics Plc.

What analysts predicted

86.12%UPSIDE

Target Price

$33.94

Current Price

$4.71

Analyzed by

3 Analysts

Target

$33.94

Silence Therapeutics Plc target price $33.94, a slight upside of 86.12% compared to current price of $4.71. According to 3 analysts rating.

Silence Therapeutics Plc Quarterly Profit & Loss

All numbers in Millions USD

	Mar 2023	Jun 2023	Sep 2023	Dec 2023	Mar 2024	Jun 2024	Sep 2024	Dec 2024	Mar 2025	Jun 2025
Total Revenue	13	11	3	2	15	0	1	24	0	0
Gross Profit	8	7	1	0	12	-2	-2	22	0	0
Operating Income	-12	-11	-12	-13	-4	-18	-22	-3	-28	-23
EBITDA	-11	-10	-10	-14	-4	-17	-21	7	-19	-22
Interest Expense	0	0	0	0	0	0	8	11	11	-
Depreciation	0	0	0	0	0	0	0	0	0	0
Income Before Tax	-12	-12	-10	-14	-3	-17	-30	23	-28	-27
Income Tax Expense	-2	-1	-2	0	-1	-1	-3	9	9	0
Net Income	-12	-13	-10	-18	-2	-19	-35	14	-28	-27
Net Profit Margin	-89.71%	-114.25%	-294.85%	-686.61%	-15.12%	-2602.34%	-2365.32%	58.26%	-20091.55%	-12211.61%

Silence Therapeutics Plc Annual Profit & Loss

All numbers in Millions USD

	Dec 2016	Dec 2017	Dec 2018	Dec 2019	Dec 2020	Dec 2021	Dec 2022	Dec 2023	Dec 2024
Total Revenue	0	0	-	0	7	16	21	32	43
Gross Profit	-9	-10	-12	0	2	6	8	19	31
Operating Income	-11	-14	-20	-22	-35	-45	-48	-49	-63
EBITDA	-11	-3	-20	-22	-35	-45	-47	-49	-48
Interest Expense	1	0	0	0	0	0	0	0	-
Depreciation	-	0	0	0	0	0	0	0	0
Income Before Tax	-10	-3	-20	-22	-36	-45	-47	-50	-44
Income Tax Expense	-1	-2	-2	-3	-3	-6	-6	-7	0
Net Income	-10	-2	-23	-25	-43	-52	-49	-54	-45
Net Profit Margin	-1096.10%	-10112.50%	0.00%	-8025.41%	-594.03%	-317.44%	-231.35%	-170.51%	-104.74%

Silence Therapeutics Plc Quarterly Cash Flow

All numbers in Millions USD

	Jun 2023	Sep 2023	Dec 2023	Mar 2024	Jun 2024	Sep 2024	Dec 2024	Mar 2025	Jun 2025
Net Income	-12	-10	-14	-3	-15	-41	22	-22	-27
Operating Cash Flow	-14	-4	-11	-7	-4	-19	-24	-12	-21
Investing Cash Flow	-4	20	0	-39	0	-28	68	-44	-1
Financing Cash Flow	3	12	9	105	0	5	19	0	0
Change in Cash	-17	29	-4	59	-3	-47	59	-56	-23

Silence Therapeutics Plc Annual Cash Flow

All numbers in Millions USD

	Dec 2016	Dec 2017	Dec 2018	Dec 2019	Dec 2020	Dec 2021	Dec 2022	Dec 2023	Dec 2024
Net Income	-10	-3	-20	-22	-36	-45	-47	-50	-36
Operating Cash Flow	-10	-9	-16	1	-10	6	-45	-39	-67
Investing Cash Flow	-4	13	-4	-15	9	8	-16	16	-21
Financing Cash Flow	0	0	0	5	15	30	43	25	142
Change in Cash	-12	3	-21	-7	13	46	-18	0	52

Global Institutional Holdings in Silence Therapeutics Plc

Funds	Holdings
TCG Crossover Management, LLC	6.42%
Siren, L.L.C.	5.91%
Redmile Group, LLC	4.69%
Morgan Stanley - Brokerage Accounts	4.23%
Lombard Odier Asset Management USA Corp	3.92%

See all

Insights on Silence Therapeutics Plc

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

POSITIVE IMPACT
Revenue Rich
Revenue is up for the last 2 quarters, 142.0K → 224.0K (in $), with an average increase of 36.6% per quarter
POSITIVE IMPACT
Profit Spike
Netprofit is up for the last 2 quarters, -28.53M → -27.35M (in $), with an average increase of 4.3% per quarter
NO EFFECT
Against Peers
In the last 3 years, Alnylam Pharmaceuticals, Inc. has given 116.5% return, outperforming this stock by 175.7%
NO EFFECT
Against Peers
In the last 1 year, Alnylam Pharmaceuticals, Inc. has given 70.6% return, outperforming this stock by 144.7%
NEGATIVE IMPACT
Price Dip
In the last 7 days, SLN stock has moved down by -9.1%

About Silence Therapeutics Plc

silence therapeutics develops a new generation of medicines by harnessing the body’s natural mechanism of rna interference, or rnai, within its cells. our proprietary technology can selectively inhibit any gene in the genome, specifically silencing the production of disease-causing proteins. using our enabling delivery systems, we have achieved an additional level of specificity by delivering our therapeutic rna molecules exclusively to target cells. silence’s proprietary rna chemistries and delivery systems are designed to improve the stability of our molecules and enhance effective delivery to target cells, providing a powerful modular technology well suited to tackle life-threatening diseases. for more information, visit us at www.silence-therapeutics.com

Organisation	Silence Therapeutics Plc
Headquarters	72 Hammersmith Road, London, United Kingdom, W14 8TH
Industry	Health Technology
CEO	Mr. Craig A. Tooman M.B.A.
E-voting on shares	Click here to vote

Key Management of Silence Therapeutics Plc

Name	Title
Ms. Gianine Esposito	Chief Human Resources Officer
Mr. J.P. Gabriel	Chief Technical Operations Officer
Mr. Craig A. Tooman M.B.A.	President, CEO & Executive Director
Dr. Steven J. Romano M.D.	Executive VP and Chief Research & Development Officer
Dr. Marie Wikstrom Lindholm Ph.D.	Chief Scientific Officer
Ms. Gem Gokmen Hopkins	Head of IR & Corporate Communications
Ms. Rhonda L. Hellums	Executive VP, CFO & Secretary
Dr. Barbara A. Ruskin J.D., Ph.D.	Senior VP and Chief Intellectual Property & Innovation Officer
Mr. Curtis Rambaran M.D.	Chief Medical Officer

FAQs

What is Silence Therapeutics Plc share price today?

Silence Therapeutics Plc share price today is $4.71 as on September 16, 2025 at 1:29 am IST at the close of the market. Silence Therapeutics Plc share today touched a day high of $4.73 and a low of $4.42.

What is the 52 week high and 52 week low for Silence Therapeutics Plc share?

Silence Therapeutics Plc share touched a 52 week high of $20.48 on October 9, 2024 and a 52 week low of $1.97 on April 10, 2025. Silence Therapeutics Plc stock price today i.e. September 16, 2025 at 1:29 am IST is closed at $4.71,which is 77.00% down from its 52 week high and 139.09% up from its 52 week low.

What is Silence Therapeutics Plc's market capitalisation today?

Silence Therapeutics Plc market capitalisation is $0.00T as on September 16, 2025 at 1:29 am IST.

How to invest in Silence Therapeutics Plc Stock (SLN) from India?

Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
Step 2: Search for Silence Therapeutics Plc on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Silence Therapeutics Plc Shares that will get you 0.3185 shares as per Silence Therapeutics Plc share price of $4.71 per share as on September 16, 2025 at 1:29 am IST.

What is the minimum amount required to buy Silence Therapeutics Plc Stock (SLN) from India?

Indian investors can start investing in Silence Therapeutics Plc (SLN) shares with as little as ₹88.042 or $1 (as of September 16, 2025 at 5:39 pm IST) using the INDmoney app.
For example: If you want to invest $10 or ₹880.42 in Silence Therapeutics Plc stock (as per the Rupee-Dollar exchange rate as on September 16, 2025 at 5:39 pm IST). Based on Silence Therapeutics Plc share’s latest price of $4.71 as on September 16, 2025 at 1:29 am IST, you will get 2.1231 shares of Silence Therapeutics Plc. Learn more about fractional shares .