Upstream Bio, Inc. share price logo

Upstream Bio, Inc.

NASDAQ: UPB

Small Cap

$9.31

-0.09

(-0.90%)

as on

Upstream Bio, Inc. Stock Performance

as on May 5, 2026 at 6:59 am IST

  • Day's Low

    Day's High

    $9.16
    $9.57
    downward going graph

    1.61%

    Downside

    2.79%

    Upside

    downward going graph

  • 52 Week's Low

    52 Week's High

    $7.25
    $33.68
    downward going graph

    22.13%

    Downside

    261.76%

    Upside

    downward going graph

Upstream Bio, Inc. share price movements today

Previous Close
$9.40
Open
$9.34
Volume
429.3K
Day's Low - High
$9.16 - $9.57
52 Week Low - High
$7.25 - $33.68

Upstream Bio, Inc. Historical Returns

1 Month Return
-2 %
3 Month Return
-64.19 %
1 Year Return
+ 7.26 %
3 Year Return
0 %
5 Year Return
0 %

Upstream Bio, Inc. Stock Fundamentals & Key Indicators

Check Upstream Bio, Inc. market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$511.5M

EPS (TTM)

-2.9353

Dividend Yield

0.00%

PE Ratio (TTM)

0

PEG Ratio

0

Return On Equity TTM

-35.44%

Upstream Bio, Inc. vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Upstream Bio, Inc. with its industry peers.

Company
Analyst View
Market Cap
5 Years Return %PE RatioProfit Margin %
Upstream Bio, Inc. image
Upstream Bio, Inc.
NA$511.5MNANA0.00%
Alnylam Pharmaceuticals Inc image
Alnylam Pharmaceuticals Inc
BUY$39.8B124.56%74.6712.55%
Vertex Pharmaceuticals Inc image
Vertex Pharmaceuticals Inc
BUY$109.3B100.99%27.732.94%
BeiGene, Ltd. image
BeiGene, Ltd.
NA$33.0BNA118.865.37%
Regeneron Pharmaceuticals Inc image
Regeneron Pharmaceuticals Inc
BUY$73.5B47.01%17.1229.65%

Stock Returns calculator for Upstream Bio, Inc. Stock including INR - Dollar returns

The Upstream Bio, Inc. stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Impact: The bonus return you make when the US Dollar rises against the Rupee; calculated on the full amount you walk away with, not just what you invested in.

Investment Value

₹1,00,000

  • 1Y

Upstream Bio, Inc. investment value today

Current value as on today

₹1,21,236

Returns

₹21,236

(+21.24%)

Returns from Upstream Bio, Inc. Stock

₹7,258 (+7.26%)

Dollar Impact

₹13,978 (+13.98%)

Upstream Bio, Inc. Stock’s Investor Sentiment and Interest

Search interest for Upstream Bio, Inc. Stock has increased by 45% in the last 30 days, reflecting an upward trend in search activity.

Time period: to

Change:45% versus previous 30 day period

Upstream Bio, Inc. Quarterly Profit & Loss

All numbers in Millions USD

Sep 2023
Dec 2023
Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Total Revenue
0
0
0
0
0
0
0
0
0
0
Gross Profit
0
0
0
0
0
0
0
0
0
0
Operating Income
-9
-14
-15
-17
-18
-26
-32
-44
-37
-46
EBITDA
-9
-14
-15
-17
-18
-26
-31
-44
-33
-46
Interest Expense
-
-
-
-
-
-
-
-
-
-
Depreciation
0
0
0
0
0
0
0
0
0
0
Income Before Tax
-3
-11
-10
-14
-15
-21
-27
-39
-33
-42
Income Tax Expense
-
-
-
-
-
-
-
-
-
-
Net Income
-3
-11
-10
-14
-15
-21
-27
-39
-33
-42
Net Profit Margin
-499.52%
-2629.56%
-1702.19%
-2878.04%
-2634.60%
-3465.25%
-4818.02%
-4265.31%
-4941.14%
-6356.14%

Upstream Bio, Inc. Annual Profit & Loss

All numbers in Millions USD

Dec 2022
Dec 2023
Dec 2024
Dec 2025
Total Revenue
1
2
2
2
Gross Profit
1
2
2
2
Operating Income
-23
-40
-77
-160
EBITDA
-23
-40
-77
-160
Interest Expense
-
-
-
-
Depreciation
0
0
0
0
Income Before Tax
-23
-20
-62
-143
Income Tax Expense
-
-
-
-
Net Income
-23
-20
-62
-143
Net Profit Margin
-1969.31%
-862.90%
-2650.04%
-5026.03%

Upstream Bio, Inc. Quarterly Cash Flow

All numbers in Millions USD

Dec 2023
Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Net Income
-11
-10
-14
-15
-21
-27
-39
-33
-42
Operating Cash Flow
-16
-17
-8
-13
-19
-41
-39
-22
-30
Investing Cash Flow
-5
13
-116
1
41
-213
12
48
58
Financing Cash Flow
0
9
140
-1
270
0
0
0
1
Change in Cash
-21
5
15
-14
292
-254
-25
26
29

Upstream Bio, Inc. Annual Cash Flow

All numbers in Millions USD

Dec 2023
Dec 2024
Dec 2025
Net Income
-20
-62
-143
Operating Cash Flow
-37
-59
-133
Investing Cash Flow
-82
-59
-93
Financing Cash Flow
129
418
2
Change in Cash
8
300
-224

Insights on Upstream Bio, Inc.

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

  • imgNO EFFECT

    Against Peers

    img

    In the last 1 year, Regeneron Pharmaceuticals, Inc. has given 17.5% return, outperforming this stock by 10.2%

  • imgNEGATIVE IMPACT

    Price Dip

    img

    In the last 3 months, UPB stock has moved down by -64.2%

About Upstream Bio, Inc.

Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases focusing on severe respiratory disorders. It offers verekitug, which is in Phase 2 trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease and in Phase I clinical trial for treating chronic obstructive pulmonary disease. The company was incorporated in 2021 and is headquartered in Waltham, Massachusetts.
OrganisationUpstream Bio, Inc.
Headquarters890 Winter Street, Waltham, MA, United States, 02451
IndustryBiotechnology
CEODr. E. Rand Sutherland M.D., M.P.H.
E-voting on sharesClick here to vote

Key Management of Upstream Bio, Inc.

Name

Title

Meggan Buckwell

Director of Corporate Communications & Investor Relations

Ms. Allison C. Ambrose J.D.

Senior VP, General Counsel & Secretary

Ms. Fang Xie Ph.D.

VP & Head of Biometrics

Dr. E. Rand Sutherland M.D., M.P.H.

CEO & Director

Mr. Aaron Deykin M.D.

Chief Medical Officer and Head of Research & Development

Ms. Stacy Price M.S., P.M.P.

Chief Technology Officer

Ms. Mersedeh Miraliakbari Pharm.D.

Senior Vice President of Regulatory Affairs & Quality

Mr. Michael Paul Gray CPA, MBA

CFO & COO

Ms. Lisa Fiering

Senior Vice President of People & Culture

Dr. Adam Houghton M.B.A., Ph.D.

Chief Business Officer

FAQs

What is Upstream Bio, Inc. share price today?

Upstream Bio, Inc. share price today is $9.31 as on at the close of the market. Upstream Bio, Inc. share today touched a day high of $9.57 and a low of $9.16.

What is the 52 week high and 52 week low for Upstream Bio, Inc. share?

Upstream Bio, Inc. share touched a 52 week high of $33.68 on and a 52 week low of $7.25 on . Upstream Bio, Inc. stock price today i.e. is closed at $9.31,which is 72.36% down from its 52 week high and 28.41% up from its 52 week low.

What is Upstream Bio, Inc.'s market capitalisation today?

Upstream Bio, Inc. market capitalisation is $0.00T as on .

How to invest in Upstream Bio, Inc. Stock (UPB) from India?

  1. Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
  2. Step 2: Search for Upstream Bio, Inc. on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Upstream Bio, Inc. Shares that will get you 0.1611 shares as per Upstream Bio, Inc. share price of $9.31 per share as on May 5, 2026 at 1:29 am IST.

What is the minimum amount required to buy Upstream Bio, Inc. Stock (UPB) from India?

Indian investors can start investing in Upstream Bio, Inc. (UPB) shares with as little as ₹95.28 or $1 (as of ) using the INDmoney app.
For example: If you want to invest $10 or ₹952.80 in Upstream Bio, Inc. stock (as per the Rupee-Dollar exchange rate as on ). Based on Upstream Bio, Inc. share’s latest price of $9.31 as on May 5, 2026 at 1:29 am IST, you will get 1.0741 shares of Upstream Bio, Inc.. Learn more about fractional shares .