Upstream Bio, Inc. share price logo

Upstream Bio, Inc.

NASDAQ: UPB

$3.41

+0.14

(+4.28%)

as on

Upstream Bio, Inc. Stock Performance

as on October 31, 2026 at 2:15 pm IST

  • Day's Low

    Day's High

    $3.15
    $3.42
    downward going graph

    7.62%

    Downside

    0.29%

    Upside

    downward going graph

  • 52 Week's Low

    52 Week's High

    $2.68
    $33.68
    downward going graph

    21.41%

    Downside

    887.68%

    Upside

    downward going graph

Upstream Bio, Inc. share price movements today

Previous Close
$3.27
Open
$3.26
Volume
1.2M
Market Cap
$163.2M
Day's Low - High
$3.15 - $3.42
52 Week Low - High
$2.68 - $33.68

Upstream Bio, Inc. Historical Returns

1 Month Return
-37.95 %
3 Month Return
-50.23 %
1 Year Return
-87.31 %
3 Year Return
0 %
5 Year Return
0 %

Upstream Bio, Inc. Stock Fundamentals & Key Indicators

Check Upstream Bio, Inc. market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$163.2M

EPS (TTM)

-2.9

Dividend Yield

0.00%

Quarterly Earnings Growth YOY

0.00%

PE Ratio (TTM)

-1.03

Industry PE ratio

-3.27

PEG Ratio

0.03

EBITDA

-156.3M

Revenue (TTM)

3.2M

Profit Margin

98.45%

Return On Equity TTM

-48.40%

Upstream Bio, Inc. vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Upstream Bio, Inc. with its industry peers.

Company
Analyst View
Market Cap
5 Years Return %PE RatioProfit Margin %Dividend Yield %
Upstream Bio, Inc. image
Upstream Bio, Inc.
Buy$163.2MNA-1.0398.45%0.00%
Moderna image
Moderna
Neutral$85.5B-35.47%-26.84-12.57%0.00%
Vertex Pharmaceuticals image
Vertex Pharmaceuticals
StrongBuy$134.2B192.00%30.5886.04%0.00%
Regeneron image
Regeneron
Buy$83.7B27.94%19.4284.86%0.45%

Stock Returns calculator for Upstream Bio, Inc. Stock including INR - Dollar returns

The Upstream Bio, Inc. stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Impact: The bonus return you make when the US Dollar rises against the Rupee; calculated on the full amount you walk away with, not just what you invested in.

Investment Value

₹1,00,000

  • 1Y

Upstream Bio, Inc. investment value today

Current value as on today

₹14,161

Returns

-₹85,839

(-85.84%)

Returns from Upstream Bio, Inc. Stock

-₹86,768 (-86.77%)

Dollar Impact

₹929 (+0.93%)

Analyst Recommendation on Upstream Bio, Inc. Stock

Based on 3 analysts

BUY

66.67%

Buy

33.33%

Hold

0.00%

Sell

Based on 3 analysts, 66.66666666666666% of analysts recommend a 'BUY' rating for Upstream Bio, Inc.. Average target price of $23.3333333333333

Upstream Bio, Inc. Share Price Target

Get share price movements and forecasts by analysts on Upstream Bio, Inc..

Current Price

$3.41

Analyzed by

3 Analysts

High

$36

0

Low

$9

Upstream Bio, Inc. target price $0, a slight upside of 0% compared to current price of $3.41. According to 3 analysts rating.

Indian Investors' Interest in Upstream Bio, Inc. Stock

Search interest for Upstream Bio, Inc. Stock has decreased by -13% in the last 30 days, reflecting a downward trend in search activity.

Time period: to

Change:-13% versus previous 30 day period

Upstream Bio, Inc. Quarterly Profit & Loss

All numbers in Millions USD

Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Mar 2026
Jun 2026
Total Revenue
0
0
0
0
0
0
0
0
1
0
Gross Profit
0
0
0
0
0
0
0
0
0
0
Operating Income
-15
-17
-18
-26
-32
-44
-37
-46
-43
-42
EBITDA
-10
-14
-15
-21
-27
-39
-33
-42
-40
-39
Interest Expense
-
-
-
-
-
-
-
-
-
-
Depreciation
0
0
0
0
0
0
0
0
0
0
Income Before Tax
-10
-14
-15
-21
-27
-39
-33
-42
-40
-39
Income Tax Expense
-
-
-
-
-
-
-
-
-
-
Net Income
-10
-14
-15
-21
-27
-39
-33
-42
-40
-39
Net Profit Margin
100.00%
100.00%
100.00%
100.00%
100.00%
100.00%
100.00%
100.00%
95.26%
100.00%

Upstream Bio, Inc. Annual Profit & Loss

All numbers in Millions USD

Dec 2022
Dec 2023
Dec 2024
Dec 2025
Total Revenue
1
2
2
2
Gross Profit
1
2
2
2
Operating Income
-23
-40
-77
-160
EBITDA
-23
-20
-62
-143
Interest Expense
-
-
-
-
Depreciation
0
0
0
0
Income Before Tax
-23
-20
-62
-143
Income Tax Expense
-
-
-
-
Net Income
-23
-20
-62
-143
Net Profit Margin
100.00%
100.00%
100.00%
100.00%

Upstream Bio, Inc. Quarterly Cash Flow

All numbers in Millions USD

Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Mar 2026
Jun 2026
Net Income
-10
-14
-15
-21
-27
-39
-33
-42
-40
-39
Operating Cash Flow
-17
-8
-13
-19
-41
-39
-22
-30
-47
-35
Investing Cash Flow
13
-116
1
41
-213
12
48
58
42
15
Financing Cash Flow
9
140
-1
270
0
0
0
1
0
2
Change in Cash
5
15
-14
292
-254
-25
26
29
-4
-17

Upstream Bio, Inc. Annual Cash Flow

All numbers in Millions USD

Dec 2022
Dec 2023
Dec 2024
Dec 2025
Net Income
-23
-20
-62
-143
Operating Cash Flow
-19
-37
-59
-133
Investing Cash Flow
0
-82
-59
-93
Financing Cash Flow
9
129
418
2
Change in Cash
-9
8
300
-224

Global Institutional Holdings in Upstream Bio, Inc.

Check out the Institutions with significant holdings in Upstream Bio, Inc..

Funds
Holdings
Fidelity Securities Fund
5.53%
Vanguard
4.14%
VANGUARD INDEX FUNDS
3.34%
iShares
3.10%
Otello Stampacchia
2.42%
See all

Upstream Bio, Inc. News & Key Events

  • img

    Today's Timeline - 01 September

    Tue, 04:30 PM

    -

    Upstream Bio outlines Phase 3 trials for verekitug in severe asthma and CRSwNP, starting Q1 2027 with 1,500 patients.

Insights on Upstream Bio, Inc.

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

  • imgPOSITIVE IMPACT

    Price Rise

    img

    In the last 7 days, UPB stock has moved up by 19.3%

  • imgNO EFFECT

    Against Peers

    img

    In the last 1 year, Moderna, Inc. Common Stock has given 720.2% return, outperforming this stock by 807.6%

About Upstream Bio, Inc.

Upstream Bio, Inc. is a biotechnology company in the clinical development stage, dedicated to innovating therapies for inflammatory conditions, particularly those affecting the severe respiratory system. Its pipeline notably features verekitug, a monoclonal antibody designed to selectively target and suppress the thymic stromal lymphopoietin receptor. Beyond this, the company is actively developing treatments for severe asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease. Established in 2021, Upstream Bio maintains its operational base in Waltham, Massachusetts.
OrganisationUpstream Bio, Inc.
Headquarters890 Winter Street, Waltham, MA, 02451, US
IndustryBiotechnology
CEOE. Rand Sutherland

Key Management of Upstream Bio, Inc.

Name

Title

Ms. Stacy Price M.S., P.M.P.

Chief Technology Officer

Meggan Buckwell

Director of Corporate Communications & Investor Relations

Ms. Allison C. Ambrose J.D.

Senior VP, General Counsel & Secretary

Ms. Lisa Fiering

Senior Vice President of People & Culture

Dr. Adam Houghton M.B.A., Ph.D.

Chief Business Officer

Ms. Mersedeh Miraliakbari Pharm.D.

Senior Vice President of Regulatory Affairs & Quality

Dr. E. Rand Sutherland M.D., M.P.H.

CEO & Director

Mr. Michael Paul Gray CPA, MBA

CFO & COO

Ms. Fang Xie Ph.D.

VP & Head of Biometrics

Mr. Aaron Deykin M.D.

Chief Medical Officer and Head of Research & Development

FAQs

What is Upstream Bio, Inc. share price today?

Upstream Bio, Inc. share price today is $3.41 as on at the close of the market. Upstream Bio, Inc. share today touched a day high of $3.42 and a low of $3.15.

What is the 52 week high and 52 week low for Upstream Bio, Inc. share?

Upstream Bio, Inc. share touched a 52 week high of $33.68 on and a 52 week low of $2.68 on . Upstream Bio, Inc. stock price today i.e. is closed at $3.41,which is 89.88% down from its 52 week high and 27.24% up from its 52 week low.

What is Upstream Bio, Inc.'s market capitalisation today?

Upstream Bio, Inc. market capitalisation is $0.00T as on .

How to invest in Upstream Bio, Inc. Stock (UPB) from India?

  1. Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
  2. Step 2: Search for Upstream Bio, Inc. on INDmoney app. Click on Buy button.

What is the minimum amount required to buy Upstream Bio, Inc. Stock (UPB) from India?

Indian investors can start investing in Upstream Bio, Inc. (UPB) shares with as little as ₹94.94999694824219 or $1 (as of ) using the INDmoney app.
For example: If you want to invest $10 or ₹949.50 in Upstream Bio, Inc. stock (as per the Rupee-Dollar exchange rate as on ). Based on Upstream Bio, Inc. share’s latest price of $3.41 as on October 31, 2026 at 8:45 am IST, you will get 2.9326 shares of Upstream Bio, Inc.. Learn more about fractional shares .