Upstream Bio Inc. Share Price

NASDAQ: UPB

Small Cap

$17.10

-0.47

(-2.68%)

Live

as on September 15, 2025 at 11:40 pm IST

$₹

Upstream Bio Inc. Stock Performance

as on September 15, 2025 at 11:40 pm IST

Day's Low
Day's High
$16.85
Day's Price Range
$17.99
$17.1
1.46%
Downside
5.20%
Upside
52 Week's Low
52 Week's High
$5.14
52-Week Price Range
$29.46
$17.1
69.94%
Downside
72.28%
Upside

Upstream Bio Inc. share price movements today

Previous Close: $17.57
Open: $17.91
Volume: 255.2K
Day's Low - High: $16.85 - $17.99
52 Week Low - High: $5.14 - $29.46

Upstream Bio Inc. Historical Returns

1 Month Return: -7.18 %
3 Month Return: + 54.67 %
1 Year Return: 0 %
3 Year Return: 0 %
5 Year Return: 0 %

Upstream Bio Inc. Stock Fundamentals & Key Indicators

Check Upstream Bio Inc. market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$947.2M

EPS (TTM)

-2.7884

Dividend Yield

0.00%

PE Ratio (TTM)

P/B Ratio

PEG Ratio

Return On Equity TTM

57403000.00%

Upstream Bio Inc. vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Upstream Bio Inc. with its industry peers.

Company	Analyst View	Market Cap	5 Years Return %	PE Ratio	Profit Margin %
Upstream Bio Inc.	NA	$947.2M	NA	NA	0.00%
Alnylam Pharmaceuticals, Inc.	BUY	$61.1B	256.98%	-505.15	-12.96%
Beone Medicines Ltd	NA	$38.7B	NA	NA	-3.89%
Vertex Pharmaceuticals Incorporated	BUY	$101.1B	47.85%	28.07	31.86%
Regeneron Pharmaceuticals, Inc.	BUY	$59.4B	-3.43%	14.11	31.37%

Upstream Bio Inc. Stock's Interest Amongst Investors

Search interest for Upstream Bio Inc. Stock has increased by 10% in the last 30 days, reflecting an upward trend in search activity.

Time period: August 16, 2025 to September 15, 2025

Change:10% versus previous 30 day period

Upstream Bio Inc. Quarterly Profit & Loss

All numbers in Millions USD

	Sep 2023	Dec 2023	Mar 2024	Jun 2024	Sep 2024	Dec 2024	Mar 2025	Jun 2025
Total Revenue	0	0	0	0	0	0	0	0
Gross Profit	0	0	0	0	0	0	0	0
Operating Income	-9	-14	-15	-17	-18	-26	-32	-44
EBITDA	-9	-14	-15	-17	-18	-26	-31	-44
Interest Expense	-	-	-	-	-	-	-	-
Depreciation	0	0	0	0	0	0	0	0
Income Before Tax	-3	-11	-10	-14	-15	-21	-27	-39
Income Tax Expense	-	-	-	-	-	-	-	-
Net Income	-3	-11	-10	-14	-15	-21	-27	-39
Net Profit Margin	-499.52%	-2629.56%	-1702.19%	-2878.04%	-2634.60%	-3465.25%	-4818.02%	-4265.31%

Upstream Bio Inc. Annual Profit & Loss

All numbers in Millions USD

	Dec 2022	Dec 2023	Dec 2024
Total Revenue	1	2	2
Gross Profit	1	2	2
Operating Income	-23	-40	-77
EBITDA	-23	-40	-77
Interest Expense	-	-	-
Depreciation	0	0	0
Income Before Tax	-23	-20	-62
Income Tax Expense	-	-	-
Net Income	-23	-20	-62
Net Profit Margin	-1969.31%	-862.90%	-2650.04%

Upstream Bio Inc. Quarterly Cash Flow

All numbers in Millions USD

	Dec 2023	Mar 2024	Jun 2024	Sep 2024	Dec 2024	Mar 2025	Jun 2025
Net Income	-11	-10	-14	-15	-21	-27	-39
Operating Cash Flow	-16	-17	-8	-13	-19	-41	-39
Investing Cash Flow	-5	13	-116	1	41	-213	12
Financing Cash Flow	0	9	140	-1	270	0	0
Change in Cash	-21	5	15	-14	292	-254	-25

Upstream Bio Inc. Annual Cash Flow

All numbers in Millions USD

	Dec 2023	Dec 2024
Net Income	-20	-62
Operating Cash Flow	-37	-59
Investing Cash Flow	-82	-59
Financing Cash Flow	129	418
Change in Cash	8	300

Insights on Upstream Bio Inc.

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

NEGATIVE IMPACT
Price Dip
In the last 7 days, UPB stock has moved down by -6.2%

About Upstream Bio Inc.

Upstream Bio, Inc. is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. The Company is developing verekitug, the only known antagonist in clinical development, that targets the receptor for thymic stromal lymphopoietin (TSLP), a cytokine which is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune mediated diseases. It has advanced this highly potent monoclonal antibody into separate phase II trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and plans to initiate development in chronic obstructive pulmonary disease. TSLP is a member of a class of epithelial cytokines, also including IL-25 and IL-33, commonly referred to as alarmins. TSLP is primarily produced by epithelial cells, especially in the lung, gastrointestinal tract and skin.

Organisation	Upstream Bio Inc.
Headquarters	890 Winter Street, Waltham, MA, United States, 02451
CEO	Dr. E. Rand Sutherland M.D., M.P.H., MPH
E-voting on shares	Click here to vote

Key Management of Upstream Bio Inc.

Name	Title
Ms. Lisa Fiering	Senior Vice President of People & Culture
Dr. Adam Houghton M.B.A., Ph.D.	Chief Business Officer
Ms. Mersedeh Miraliakbari Pharm.D.	Senior Vice President of Regulatory Affairs & Quality
Ms. Fang Xie Ph.D.	VP & Head of Biometrics
Mr. Michael Paul Gray CPA, MBA	CFO & COO
Ms. Stacy Price M.S., P.M.P.	Chief Technology Officer
Mr. Aaron Deykin M.D.	Chief Medical Officer and Head of Research & Development
Dr. Sumathi Sivapalasingam M.D.	VP & Head of Clinical Development
Dr. E. Rand Sutherland M.D., M.P.H., MPH	CEO & Director
Ms. Allison C. Ambrose J.D.	Senior VP, General Counsel & Secretary

FAQs

What is Upstream Bio Inc. share price today?

Upstream Bio Inc. share price today is $17.1 as on September 15, 2025 at 11:40 pm IST. Upstream Bio Inc. share today touched a day high of $17.99 and a low of $16.85.

What is the 52 week high and 52 week low for Upstream Bio Inc. share?

Upstream Bio Inc. share touched a 52 week high of $29.46 on November 6, 2024 and a 52 week low of $5.14 on April 9, 2025. Upstream Bio Inc. stock price today i.e. September 15, 2025 at 11:40 pm IST is trending at $17.1,which is 41.95% down from its 52 week high and 232.68% up from its 52 week low.

What is Upstream Bio Inc.'s market capitalisation today?

Upstream Bio Inc. market capitalisation is $0.00T as on September 15, 2025 at 11:40 pm IST.

How to invest in Upstream Bio Inc. Stock (UPB) from India?

Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
Step 2: Search for Upstream Bio Inc. on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Upstream Bio Inc. Shares that will get you 0.0877 shares as per Upstream Bio Inc. share price of $17.1 per share as on September 15, 2025 at 11:40 pm IST.

What is the minimum amount required to buy Upstream Bio Inc. Stock (UPB) from India?

Indian investors can start investing in Upstream Bio Inc. (UPB) shares with as little as ₹88.141 or $1 (as of September 15, 2025 at 11:42 pm IST) using the INDmoney app.
For example: If you want to invest $10 or ₹881.41 in Upstream Bio Inc. stock (as per the Rupee-Dollar exchange rate as on September 15, 2025 at 11:42 pm IST). Based on Upstream Bio Inc. share’s latest price of $17.1 as on September 15, 2025 at 11:40 pm IST, you will get 0.5848 shares of Upstream Bio Inc.. Learn more about fractional shares .