Upstream Bio Inc. Share Price (NASDAQ: UPB)

Upstream Bio Inc. Stock Performance

as on October 17, 2025 at 1:29 am IST

Day's Low
Day's High
$21.39
Day's Price Range
$22.39
$22.29
4.04%
Downside
0.45%
Upside
52 Week's Low
52 Week's High
$5.14
52-Week Price Range
$29.46
$22.29
76.94%
Downside
32.17%
Upside

Upstream Bio Inc. share price movements today

Previous Close: $21.69
Open: $21.89
Volume: 407.8K
Day's Low - High: $21.39 - $22.39
52 Week Low - High: $5.14 - $29.46

Upstream Bio Inc. Historical Returns

1 Month Return: + 25.01 %
3 Month Return: + 98.63 %
1 Year Return: -8.21 %
3 Year Return: 0 %
5 Year Return: 0 %

Upstream Bio Inc. Stock Fundamentals & Key Indicators

Check Upstream Bio Inc. market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$1.1B

EPS (TTM)

-2.8247

Dividend Yield

0.00%

PE Ratio (TTM)

PEG Ratio

Return On Equity TTM

1388400.00%

Upstream Bio Inc. vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Upstream Bio Inc. with its industry peers.

Company	Analyst View	Market Cap	5 Years Return %	PE Ratio	Profit Margin %
Upstream Bio Inc.	NA	$1.1B	NA	NA	0.00%
Alnylam Pharmaceuticals, Inc.	BUY	$61.5B	223.43%	-505.15	-12.96%
Beone Medicines Ltd	NA	$37.1B	NA	NA	-3.89%
Vertex Pharmaceuticals Incorporated	BUY	$105.7B	87.04%	28.99	31.86%
Regeneron Pharmaceuticals, Inc.	BUY	$59.6B	-3.89%	14.07	31.37%

Stock Returns calculator for Upstream Bio Inc. Stock including INR - Dollar returns

The Upstream Bio Inc. stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Return is the profit earned when the US dollar rises in value compared to the Indian rupee.

Investment Value

₹1,00,000

Upstream Bio Inc. investment value today

Current value as on today

₹98,976

Returns

₹1,024

(-1.02%)

Returns from Upstream Bio Inc. Stock

₹5,671 (-5.67%)

Dollar Returns*

₹4,647 (+4.65%)

Upstream Bio Inc. Stock’s Investor Sentiment and Interest

Search interest for Upstream Bio Inc. Stock has increased by 40% in the last 30 days, reflecting an upward trend in search activity.

Time period: September 17, 2025 to October 17, 2025

Change:40% versus previous 30 day period

Upstream Bio Inc. Quarterly Profit & Loss

All numbers in Millions USD

	Sep 2023	Dec 2023	Mar 2024	Jun 2024	Sep 2024	Dec 2024	Mar 2025	Jun 2025
Total Revenue	0	0	0	0	0	0	0	0
Gross Profit	0	0	0	0	0	0	0	0
Operating Income	-9	-14	-15	-17	-18	-26	-32	-44
EBITDA	-9	-14	-15	-17	-18	-26	-31	-44
Interest Expense	-	-	-	-	-	-	-	-
Depreciation	0	0	0	0	0	0	0	0
Income Before Tax	-3	-11	-10	-14	-15	-21	-27	-39
Income Tax Expense	-	-	-	-	-	-	-	-
Net Income	-3	-11	-10	-14	-15	-21	-27	-39
Net Profit Margin	-499.52%	-2629.56%	-1702.19%	-2878.04%	-2634.60%	-3465.25%	-4818.02%	-4265.31%

Upstream Bio Inc. Annual Profit & Loss

All numbers in Millions USD

	Dec 2022	Dec 2023	Dec 2024
Total Revenue	1	2	2
Gross Profit	1	2	2
Operating Income	-23	-40	-77
EBITDA	-23	-40	-77
Interest Expense	-	-	-
Depreciation	0	0	0
Income Before Tax	-23	-20	-62
Income Tax Expense	-	-	-
Net Income	-23	-20	-62
Net Profit Margin	-1969.31%	-862.90%	-2650.04%

Upstream Bio Inc. Quarterly Cash Flow

All numbers in Millions USD

	Dec 2023	Mar 2024	Jun 2024	Sep 2024	Dec 2024	Mar 2025	Jun 2025
Net Income	-11	-10	-14	-15	-21	-27	-39
Operating Cash Flow	-16	-17	-8	-13	-19	-41	-39
Investing Cash Flow	-5	13	-116	1	41	-213	12
Financing Cash Flow	0	9	140	-1	270	0	0
Change in Cash	-21	5	15	-14	292	-254	-25

Upstream Bio Inc. Annual Cash Flow

All numbers in Millions USD

	Dec 2023	Dec 2024
Net Income	-20	-62
Operating Cash Flow	-37	-59
Investing Cash Flow	-82	-59
Financing Cash Flow	129	418
Change in Cash	8	300

Insights on Upstream Bio Inc.

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

POSITIVE IMPACT
Price Rise
In the last 7 days, UPB stock has moved up by 9.6%
NO EFFECT
Against Peers
In the last 1 year, Alnylam Pharmaceuticals, Inc. has given 56.5% return, outperforming this stock by 64.7%

About Upstream Bio Inc.

Upstream Bio, Inc. is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. The Company is developing verekitug, the only known antagonist in clinical development, that targets the receptor for thymic stromal lymphopoietin (TSLP), a cytokine which is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune mediated diseases. It has advanced this highly potent monoclonal antibody into separate phase II trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and plans to initiate development in chronic obstructive pulmonary disease. TSLP is a member of a class of epithelial cytokines, also including IL-25 and IL-33, commonly referred to as alarmins. TSLP is primarily produced by epithelial cells, especially in the lung, gastrointestinal tract and skin.

Organisation	Upstream Bio Inc.
Headquarters	890 Winter Street, Waltham, MA, United States, 02451
CEO	Dr. E. Rand Sutherland M.D., M.P.H., MPH
E-voting on shares	Click here to vote

Key Management of Upstream Bio Inc.

Name	Title
Dr. E. Rand Sutherland M.D., M.P.H., MPH	CEO & Director
Ms. Stacy Price M.S., P.M.P.	Chief Technology Officer
Meggan Buckwell	Director of Corporate Communications & Investor Relations
Dr. Adam Houghton M.B.A., Ph.D.	Chief Business Officer
Mr. Aaron Deykin M.D.	Chief Medical Officer and Head of Research & Development
Mr. Michael Paul Gray CPA, MBA	CFO & COO
Ms. Allison C. Ambrose J.D.	Senior VP, General Counsel & Secretary
Ms. Lisa Fiering	Senior Vice President of People & Culture
Ms. Mersedeh Miraliakbari Pharm.D.	Senior Vice President of Regulatory Affairs & Quality
Ms. Fang Xie Ph.D.	VP & Head of Biometrics

FAQs

What is Upstream Bio Inc. share price today?

Upstream Bio Inc. share price today is $22.29 as on October 17, 2025 at 1:29 am IST at the close of the market. Upstream Bio Inc. share today touched a day high of $22.39 and a low of $21.39.

What is the 52 week high and 52 week low for Upstream Bio Inc. share?

Upstream Bio Inc. share touched a 52 week high of $29.46 on November 6, 2024 and a 52 week low of $5.14 on April 9, 2025. Upstream Bio Inc. stock price today i.e. October 17, 2025 at 1:29 am IST is closed at $22.29,which is 24.34% down from its 52 week high and 333.66% up from its 52 week low.

What is Upstream Bio Inc.'s market capitalisation today?

Upstream Bio Inc. market capitalisation is $0.00T as on October 17, 2025 at 1:29 am IST.

How to invest in Upstream Bio Inc. Stock (UPB) from India?

Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
Step 2: Search for Upstream Bio Inc. on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Upstream Bio Inc. Shares that will get you 0.0673 shares as per Upstream Bio Inc. share price of $22.29 per share as on October 17, 2025 at 1:29 am IST.

What is the minimum amount required to buy Upstream Bio Inc. Stock (UPB) from India?

Indian investors can start investing in Upstream Bio Inc. (UPB) shares with as little as ₹87.83 or $1 (as of October 17, 2025 at 5:37 am IST) using the INDmoney app.
For example: If you want to invest $10 or ₹878.30 in Upstream Bio Inc. stock (as per the Rupee-Dollar exchange rate as on October 17, 2025 at 5:37 am IST). Based on Upstream Bio Inc. share’s latest price of $22.29 as on October 17, 2025 at 1:29 am IST, you will get 0.4486 shares of Upstream Bio Inc.. Learn more about fractional shares .