Spruce Biosciences Inc. share price logo

Spruce Biosciences Inc.

NASDAQ: SPRB

Small Cap

$55.11

+2.34

(+4.43%)

as on

Spruce Biosciences Inc. Stock Performance

as on June 27, 2026 at 2:15 pm IST

  • Day's Low

    Day's High

    $51.78
    $55.20
    downward going graph

    6.04%

    Downside

    0.16%

    Upside

    downward going graph

  • 52 Week's Low

    52 Week's High

    $4.77
    $240.00
    downward going graph

    91.34%

    Downside

    335.49%

    Upside

    downward going graph

Spruce Biosciences Inc. share price movements today

Previous Close
$52.77
Open
$51.84
Volume
279.0K
Day's Low - High
$51.78 - $55.20
52 Week Low - High
$4.77 - $240.00

Spruce Biosciences Inc. Historical Returns

1 Month Return
+ 1.85 %
3 Month Return
-23.64 %
1 Year Return
+ 905.14 %
3 Year Return
+ 2277.03 %
5 Year Return
+ 379.73 %

Spruce Biosciences Inc. Stock Fundamentals & Key Indicators

Check Spruce Biosciences Inc. market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$142.8M

EPS (TTM)

-25.635

Dividend Yield

0.00%

Quarterly Earnings Growth YOY

0.00%

PE Ratio (TTM)

0

PEG Ratio

0

EBITDA

-25.8M

Revenue (TTM)

697.0K

Profit Margin

0.00%

Return On Equity TTM

-148.85%

Spruce Biosciences Inc. vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Spruce Biosciences Inc. with its industry peers.

Company
Analyst View
Market Cap
5 Years Return %PE RatioProfit Margin %Dividend Yield %
Spruce Biosciences Inc. image
Spruce Biosciences Inc.
BUY$142.8M379.73%NA0.00%NA
Alnylam Pharmaceuticals Inc. image
Alnylam Pharmaceuticals Inc.
BUY$39.3B67.15%74.0712.55%NA
Vertex Pharmaceuticals Inc. image
Vertex Pharmaceuticals Inc.
BUY$120.6B147.08%28.1735.51%NA
Regeneron Pharmaceuticals Inc. image
Regeneron Pharmaceuticals Inc.
BUY$65.4B12.64%15.2229.65%0.58%

Stock Returns calculator for Spruce Biosciences Inc. Stock including INR - Dollar returns

The Spruce Biosciences Inc. stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Impact: The bonus return you make when the US Dollar rises against the Rupee; calculated on the full amount you walk away with, not just what you invested in.

Investment Value

₹1,00,000

  • 1Y

  • 3Y

  • 5Y

Spruce Biosciences Inc. investment value today

Current value as on today

₹11,55,053

Returns

₹10,55,053

(+1.06K%)

Returns from Spruce Biosciences Inc. Stock

₹9,49,714 (+949.71%)

Dollar Impact

₹1,05,339 (+105.34%)

Analyst Recommendation on Spruce Biosciences Inc. Stock

Based on 13 analysts

BUY

53.85%

Buy

46.15%

Hold

0.00%

Sell

Based on 13 analysts, 53.85% of analysts recommend a 'BUY' rating for Spruce Biosciences Inc.. Average target price of $149.71

Spruce Biosciences Inc. Share Price Target

Get share price movements and forecasts by analysts on Spruce Biosciences Inc..

What analysts predicted

63.19%UPSIDE

Target Price

$149.71

Current Price

$55.11

Analyzed by

13 Analysts

Target

$149.71

Spruce Biosciences Inc. target price $149.71, a slight upside of 63.19% compared to current price of $55.11. According to 13 analysts rating.

Indian Investors' Interest in Spruce Biosciences Inc. Stock

Search interest for Spruce Biosciences Inc. Stock has decreased by -22% in the last 30 days, reflecting a downward trend in search activity.

Time period: to

Change:-22% versus previous 30 day period

Spruce Biosciences Inc. Quarterly Profit & Loss

All numbers in Millions USD

Dec 2023
Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Mar 2026
Total Revenue
2
2
1
0
0
0
-
-
-
-
Gross Profit
2
2
1
0
-
0
-
-
0
-
Operating Income
-11
-12
-10
-9
-24
-14
-2
-8
-11
-11
EBITDA
-9
-11
-9
-8
-
-13
-2
-8
-14
-11
Interest Expense
0
0
0
0
0
0
0
0
0
0
Depreciation
0
0
0
0
0
0
0
0
0
0
Income Before Tax
-9
-11
-9
-8
-23
-14
-2
-8
-14
-12
Income Tax Expense
0
0
-
-
-
-
-
-
-
-
Net Income
-9
-11
-9
-8
-23
-14
-2
-8
-14
-12
Net Profit Margin
-344.65%
-580.67%
-570.25%
-1440.37%
-3380.06%
-2014.49%
0.00%
0.00%
0.00%
0.00%

Spruce Biosciences Inc. Annual Profit & Loss

All numbers in Millions USD

Dec 2018
Dec 2019
Dec 2020
Dec 2021
Dec 2022
Dec 2023
Dec 2024
Dec 2025
Total Revenue
-
-
-
-
1
10
4
-
Gross Profit
0
0
0
0
0
10
4
0
Operating Income
-9
-13
-29
-42
-47
-51
-56
-36
EBITDA
-9
-13
-29
-41
-45
-47
-52
-38
Interest Expense
-
0
0
0
0
0
0
0
Depreciation
0
0
0
0
0
0
0
0
Income Before Tax
-9
-13
-29
-42
-46
-47
-53
-38
Income Tax Expense
0
0
0
0
-1
0
-
-
Net Income
-9
-13
-29
-42
-46
-47
-53
-38
Net Profit Margin
0.00%
0.00%
0.00%
0.00%
-2351.32%
-474.96%
-1079.94%
0.00%

Spruce Biosciences Inc. Quarterly Cash Flow

All numbers in Millions USD

Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Mar 2026
Net Income
-11
-9
-8
-23
-14
-2
-8
-14
-12
Operating Cash Flow
-14
-11
-9
-20
-12
-8
-5
-6
-8
Investing Cash Flow
-
-
-
-
-
-
-
-
0
Financing Cash Flow
0
0
0
0
0
0
0
44
13
Change in Cash
-15
-11
-9
-21
-13
-9
-5
38
5

Spruce Biosciences Inc. Annual Cash Flow

All numbers in Millions USD

Dec 2019
Dec 2020
Dec 2021
Dec 2022
Dec 2023
Dec 2024
Dec 2025
Net Income
-13
-29
-42
-46
-47
-53
-38
Operating Cash Flow
-12
-27
-35
-41
-33
-55
-33
Investing Cash Flow
0
0
-79
23
55
-
-
Financing Cash Flow
12
181
0
0
49
-1
43
Change in Cash
0
153
-114
-18
71
-57
10

Global Institutional Holdings in Spruce Biosciences Inc.

Funds
Holdings
Geode Capital Management, LLC
0.94%
Northern Trust Corp
0.19%
ADAR1 Capital Management LLC
4.27%
Rock Springs Capital Management LP
6.18%
SkyView Investment Advisors, LLC
0.22%
See all

Spruce Biosciences Inc. News & Key Events

  • img

    Today's Timeline - 08 October

    Thu, 02:02 AM

    -

    Spruce Biosciences announces $50M private placement to advance enzyme replacement therapy for Sanfilippo Syndrome Type B.

Insights on Spruce Biosciences Inc.

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

  • imgPOSITIVE IMPACT

    Best in 3 Years

    img

    In the last 3 years, SPRB has outperformed top 5 stocks with highest market-cap in its industry

  • imgPOSITIVE IMPACT

    Best in 1 Year

    img

    In the last 1 year, SPRB has outperformed top 5 stocks with highest market-cap in its industry

  • imgPOSITIVE IMPACT

    Price Rise

    img

    In the last 1 year, SPRB stock has moved up by 920.6%

About Spruce Biosciences Inc.

Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders. The company develops TA-ERT, a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase, which is an enzyme replacement therapy for patients with Sanfilippo Syndrome Type B. It also develops Tildacerfont for treating a highly debilitating mental disorder characterized by depressed mood with cognitive-affective and somatic changes, including anhedonia, weight alterations, and altered sleeping patterns. In addition, the company develops SPR202 for the treatment of Congenital Adrenal Hyperplasia (CAH), a chronic and potentially life-threatening rare disease with no cure. The company has a license agreement with Eli Lilly and Company to research, develop, and commercialize various pharmaceutical compounds. It also has a collaboration and license agreement with Kaken Pharmaceutical Co. Ltd. to develop, manufacture, and commercialize Tildacerfont for the treatment of CAH in Japan. Spruce Biosciences, Inc. was incorporated in 2014 and is headquartered in South San Francisco, California.
OrganisationSpruce Biosciences Inc.
Headquarters611 Gateway Boulevard, South San Francisco, CA, United States, 94080
IndustryBiotechnology
CEODr. Javier Szwarcberg M.D., M.P.H.
E-voting on sharesClick here to vote

Key Management of Spruce Biosciences Inc.

Name

Title

Dr. Kirk Ways M.D., Ph.D.

Chief Medical Officer & Director

Mr. Bruno Gagnon BPHARM, M.Sc.

Senior Vice President of Clinical Development Operations

Dr. Daven Mody Pharm.D.

Senior Vice President of Regulatory & Quality

Mr. Corwin Dale Hooks

Chief Commercial Officer

Mr. Michael G. Grey

Executive Chairman

Dr. Javier Szwarcberg M.D., M.P.H.

CEO & Director

Mr. Samir M. Gharib CPA, M.B.A.

President & CFO

FAQs

What is Spruce Biosciences Inc. share price today?

Spruce Biosciences Inc. share price today is $55.11 as on at the close of the market. Spruce Biosciences Inc. share today touched a day high of $55.2 and a low of $51.78.

What is the 52 week high and 52 week low for Spruce Biosciences Inc. share?

Spruce Biosciences Inc. share touched a 52 week high of $240 on and a 52 week low of $4.77 on . Spruce Biosciences Inc. stock price today i.e. is closed at $55.11,which is 77.04% down from its 52 week high and 1055.35% up from its 52 week low.

What is Spruce Biosciences Inc.'s market capitalisation today?

Spruce Biosciences Inc. market capitalisation is $0.00T as on .

How to invest in Spruce Biosciences Inc. Stock (SPRB) from India?

  1. Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
  2. Step 2: Search for Spruce Biosciences Inc. on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Spruce Biosciences Inc. Shares that will get you 0.0272 shares as per Spruce Biosciences Inc. share price of $55.11 per share as on June 27, 2026 at 8:45 am IST.

What is the minimum amount required to buy Spruce Biosciences Inc. Stock (SPRB) from India?

Indian investors can start investing in Spruce Biosciences Inc. (SPRB) shares with as little as ₹94.3 or $1 (as of ) using the INDmoney app.
For example: If you want to invest $10 or ₹943.00 in Spruce Biosciences Inc. stock (as per the Rupee-Dollar exchange rate as on ). Based on Spruce Biosciences Inc. share’s latest price of $55.11 as on June 27, 2026 at 8:45 am IST, you will get 0.1815 shares of Spruce Biosciences Inc.. Learn more about fractional shares .

What are the returns that Spruce Biosciences Inc. has given to Indian investors in the last 5 years?

Spruce Biosciences Inc. stock has given 379.73% share price returns and 27.1% dollar appreciation to an Indian investor in the last 5 years.
Read more about How do Currency Exchange Rates impact your returns on US Stock Investments?