Spruce Biosciences share price logo

Spruce Biosciences

NASDAQ: SPRB

$43.45

-1.10

(-2.47%)

Live

as on

Spruce Biosciences Stock Performance

as on November 4, 2026 at 4:56 am IST

  • Day's High

    $43.45
    $45.05

    3.68%

    Upside

    downward going graph

  • 52 Week's Low

    52 Week's High

    $38.06
    $129.00
    downward going graph

    12.41%

    Downside

    196.89%

    Upside

    downward going graph

Spruce Biosciences share price movements today

Previous Close
$44.55
Open
$45.05
Volume
120.1K
Market Cap
$133.3M
Day's Low - High
$43.45 - $45.05
52 Week Low - High
$38.06 - $129.00

Spruce Biosciences Historical Returns

1 Month Return
-2.54 %
3 Month Return
+ 3.27 %
1 Year Return
-57.47 %
3 Year Return
-45.75 %
5 Year Return
-87.44 %

Spruce Biosciences Stock Fundamentals & Key Indicators

Check Spruce Biosciences market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$133.3M

EPS (TTM)

-40.87

Dividend Yield

0.00%

Quarterly Earnings Growth YOY

0.00%

PE Ratio (TTM)

-1.14

Industry PE ratio

-3.13

PEG Ratio

-0.02

EBITDA

-48.7M

Revenue (TTM)

-

Profit Margin

0.00%

Return On Equity TTM

-123.53%

Spruce Biosciences vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Spruce Biosciences with its industry peers.

Company
Analyst View
Market Cap
5 Years Return %PE RatioProfit Margin %Dividend Yield %
Spruce Biosciences image
Spruce Biosciences
StrongBuy$133.3M-87.44%-1.140.00%0.00%
Moderna image
Moderna
Neutral$88.5B-36.16%-27.78-12.57%0.00%
Vertex Pharmaceuticals image
Vertex Pharmaceuticals
StrongBuy$141.7B192.56%32.2786.04%0.00%
Regeneron image
Regeneron
Buy$95.5B47.41%19.7685.77%0.40%

Stock Returns calculator for Spruce Biosciences Stock including INR - Dollar returns

The Spruce Biosciences stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Impact: The bonus return you make when the US Dollar rises against the Rupee; calculated on the full amount you walk away with, not just what you invested in.

Investment Value

₹1,00,000

  • 1Y

  • 3Y

  • 5Y

Spruce Biosciences investment value today

Current value as on today

₹44,293

Returns

-₹55,707

(-55.71%)

Returns from Spruce Biosciences Stock

-₹58,520 (-58.52%)

Dollar Impact

₹2,813 (+2.81%)

Analyst Recommendation on Spruce Biosciences Stock

Based on 4 analysts

BUY

100.00%

Buy

0.00%

Hold

0.00%

Sell

Based on 4 analysts, 100% of analysts recommend a 'BUY' rating for Spruce Biosciences. Average target price of $148

Spruce Biosciences Share Price Target

Get share price movements and forecasts by analysts on Spruce Biosciences.

What analysts predicted

70.64%UPSIDE

Target Price

$148

Current Price

$43.45

Analyzed by

4 Analysts

High

$230

Target

$148.00

Low

$104

Spruce Biosciences target price $148, a slight upside of 70.64% compared to current price of $43.45. According to 4 analysts rating.

Indian Investors' Interest in Spruce Biosciences Stock

Search interest for Spruce Biosciences Stock has increased by 9% in the last 30 days, reflecting an upward trend in search activity.

Time period: to

Change:9% versus previous 30 day period

Spruce Biosciences Quarterly Profit & Loss

All numbers in Millions USD

Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Mar 2026
Jun 2026
Total Revenue
2
1
0
0
-
-
-
-
-
-
Gross Profit
2
1
0
0
-
-
-
-
-
-
Operating Income
-12
-10
-9
-24
-14
-2
-8
-11
-11
-16
EBITDA
-11
-9
-8
-23
-13
-2
-8
-14
-11
-14
Interest Expense
0
0
0
0
0
0
0
0
0
1
Depreciation
0
0
0
0
0
0
0
0
0
0
Income Before Tax
-11
-9
-8
-23
-14
-2
-8
-14
-12
-16
Income Tax Expense
-
-
-
-
-
-
-
-
-
-
Net Income
-11
-9
-8
-23
-14
-2
-8
-14
-12
-16
Net Profit Margin
100.00%
100.00%
100.00%
100.00%
0.00%
0.00%
0.00%
0.00%
0.00%
0.00%

Spruce Biosciences Annual Profit & Loss

All numbers in Millions USD

Dec 2018
Dec 2019
Dec 2020
Dec 2021
Dec 2022
Dec 2023
Dec 2024
Dec 2025
Total Revenue
-
-
-
-
-
10
4
-
Gross Profit
0
0
-
-
-
10
4
-
Operating Income
-9
-13
-29
-42
-47
-51
-56
-36
EBITDA
-9
-13
-29
-41
-45
-47
-52
-38
Interest Expense
-
0
0
0
0
0
0
0
Depreciation
0
0
0
0
0
0
0
0
Income Before Tax
-9
-13
-29
-42
-46
-47
-53
-38
Income Tax Expense
-
-
-
-
-
-
-
-
Net Income
-9
-13
-29
-42
-46
-47
-53
-38
Net Profit Margin
0.00%
0.00%
0.00%
0.00%
0.00%
100.00%
100.00%
0.00%

Spruce Biosciences Quarterly Cash Flow

All numbers in Millions USD

Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Mar 2026
Jun 2026
Net Income
-11
-9
-8
-23
-14
-2
-8
-14
-12
-16
Operating Cash Flow
-14
-11
-9
-20
-12
-8
-5
-6
-8
-22
Investing Cash Flow
-
-
-
-
-
-
-
-
0
0
Financing Cash Flow
0
0
0
0
0
0
0
44
13
64
Change in Cash
-15
-11
-9
-21
-13
-9
-5
38
5
42

Spruce Biosciences Annual Cash Flow

All numbers in Millions USD

Dec 2018
Dec 2019
Dec 2020
Dec 2021
Dec 2022
Dec 2023
Dec 2024
Dec 2025
Net Income
-9
-13
-29
-42
-46
-47
-53
-38
Operating Cash Flow
-8
-12
-27
-35
-41
-33
-55
-33
Investing Cash Flow
-
0
0
-79
23
55
-
-
Financing Cash Flow
-
12
181
0
0
49
-1
43
Change in Cash
-8
0
153
-114
-18
71
-57
10

Global Institutional Holdings in Spruce Biosciences

Check out the Institutions with significant holdings in Spruce Biosciences.

Funds
Holdings
BlackRock, Inc.
6.54%
Vanguard
4.66%
VANGUARD INDEX FUNDS
4.06%
iShares
3.45%
Fidelity Salem Street Trust
1.15%
See all

Spruce Biosciences News & Key Events

  • img

    Today's Timeline - 08 October

    Thu, 02:02 AM

    -

    Spruce Biosciences announces $50M private placement to advance enzyme replacement therapy for Sanfilippo Syndrome Type B.

Insights on Spruce Biosciences

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

  • imgNO EFFECT

    Against Peers

    img

    In the last 1 year, Moderna, Inc. Common Stock has given 786.5% return, outperforming this stock by 844.0%

  • imgNO EFFECT

    Against Peers

    img

    In the last 3 years, Moderna, Inc. Common Stock has given 184.8% return, outperforming this stock by 230.6%

  • imgNEGATIVE IMPACT

    Price Dip

    img

    In the last 1 year, SPRB stock has moved down by -57.5%

About Spruce Biosciences

Spruce Biosciences, Inc., founded in 2014 and situated in Daly City, California, operates as a biopharmaceutical enterprise. Its primary objective is to advance and bring to market innovative treatments, particularly for uncommon endocrine conditions. A central component of its therapeutic pipeline is tildacerfont, a non-steroidal drug candidate. This compound is currently undergoing Phase 2b clinical assessments in adult patients with congenital adrenal hyperplasia (CAH), with the aim of optimizing disease management and lessening dependence on steroid medications by examining reductions in glucocorticoid levels and their clinical consequences. Tildacerfont is also progressing through Phase 2 trials for pediatric classic CAH, as well as investigating its efficacy in women suffering from polycystic ovary syndrome (PCOS). Additionally, Spruce Biosciences maintains a collaborative licensing agreement with Eli Lilly and Company to jointly explore, formulate, and commercialize various pharmaceutical substances.
OrganisationSpruce Biosciences
Headquarters611 Gateway Boulevard, South San Francisco, CA, 94080, US
IndustryBiotechnology
CEOJavier Szwarcberg

Key Management of Spruce Biosciences

Name

Title

Ms. Saba Sile M.D.

Senior Vice President of Clinical Development

Mr. Michael G. Grey

Executive Chairman

Dr. Javier Szwarcberg M.D., M.P.H.

CEO & Director

Mr. Samir M. Gharib CPA, M.B.A.

President & CFO

Mr. Eric Jordan M.B.A.

Vice President of Marketing

Mr. Bruno Gagnon BPHARM, M.Sc.

Senior Vice President of Clinical Development Operations

Dr. Daven Mody M.B.A., Pharm.D.

Senior Vice President of Regulatory & Quality

Mr. Corwin Dale Hooks M.B.A.

Chief Commercial Officer

Dr. Adrian Quartel FFPM, M.D.

Chief Medical Officer

Ms. Tina Gullotta CPA

Vice President of Finance and Corporate Controller

FAQs

What is Spruce Biosciences share price today?

Spruce Biosciences share price today is $43.45 as on . Spruce Biosciences share today touched a day high of $45.05 and a low of $43.45.

What is the 52 week high and 52 week low for Spruce Biosciences share?

Spruce Biosciences share touched a 52 week high of $129.00 on and a 52 week low of $38.06 on . Spruce Biosciences stock price today i.e. is trending at $43.45,which is 66.32% down from its 52 week high and 14.16% up from its 52 week low.

What is Spruce Biosciences's market capitalisation today?

Spruce Biosciences market capitalisation is $0.00T as on .

How to invest in Spruce Biosciences Stock (SPRB) from India?

  1. Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
  2. Step 2: Search for Spruce Biosciences on INDmoney app. Click on Buy button.

What is the minimum amount required to buy Spruce Biosciences Stock (SPRB) from India?

Indian investors can start investing in Spruce Biosciences (SPRB) shares with as little as ₹94.73999786376953 or $1 (as of ) using the INDmoney app.
For example: If you want to invest $10 or ₹947.40 in Spruce Biosciences stock (as per the Rupee-Dollar exchange rate as on ). Based on Spruce Biosciences share’s latest price of $43.45 as on November 3, 2026 at 11:26 pm IST, you will get 0.2301 shares of Spruce Biosciences. Learn more about fractional shares .

What are the returns that Spruce Biosciences has given to Indian investors in the last 5 years?

Spruce Biosciences stock has given -87.44% share price returns and 27.07% dollar appreciation to an Indian investor in the last 5 years.
Read more about How do Currency Exchange Rates impact your returns on US Stock Investments?