Spero Therapeutics Inc (SPRO) Live Share Price, Invest From India

Spero Therapeutics Inc Stock Performance

as on December 6, 2025 at 2:29 am IST

Day's Low
Day's High
$2.25
Day's Price Range
$2.31
$2.27
0.88%
Downside
1.76%
Upside
52 Week's Low
52 Week's High
$0.51
52-Week Price Range
$3.22
$2.27
77.74%
Downside
41.85%
Upside

Spero Therapeutics Inc share price movements today

Previous Close: $2.28
Open: $2.29
Volume: 374.1K
Day's Low - High: $2.25 - $2.31
52 Week Low - High: $0.51 - $3.22

Spero Therapeutics Inc Historical Returns

1 Month Return: -5.97 %
3 Month Return: + 6.28 %
1 Year Return: + 96.98 %
3 Year Return: + 20.9 %
5 Year Return: -86.91 %

Spero Therapeutics Inc Stock Fundamentals & Key Indicators

Check Spero Therapeutics Inc market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$128.5M

EPS (TTM)

-0.65

Dividend Yield

0.00%

Quarterly Earnings Growth YOY

0.75%

PE Ratio (TTM)

PEG Ratio

EBITDA

-45.1M

Revenue (TTM)

40.5M

Profit Margin

-108.11%

Return On Equity TTM

-95.30%

Spero Therapeutics Inc vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Spero Therapeutics Inc with its industry peers.

Company	Analyst View	Market Cap	5 Years Return %	PE Ratio	Profit Margin %
Spero Therapeutics Inc	BUY	$128.5M	-86.91%	NA	-108.11%
Insmed Incorporated	BUY	$43.7B	410.81%	-16.34	-264.83%
Alnylam Pharmaceuticals, Inc.	BUY	$62.5B	258.57%	1690.32	1.36%
Vertex Pharmaceuticals Incorporated	BUY	$118.7B	100.27%	30.49	31.35%
Regeneron Pharmaceuticals, Inc.	BUY	$76.7B	46.78%	17.33	32.13%

Stock Returns calculator for Spero Therapeutics Inc Stock including INR - Dollar returns

The Spero Therapeutics Inc stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Return is the profit earned when the US dollar rises in value compared to the Indian rupee.

Investment Value

₹1,00,000

Spero Therapeutics Inc investment value today

Current value as on today

₹2,01,846

Returns

₹1,01,846

(+101.85%)

Returns from Spero Therapeutics Inc Stock

₹95,690 (+95.69%)

Dollar Returns*

₹6,157 (+6.16%)

Analyst Recommendation on Spero Therapeutics Inc Stock

Based on 10 analysts

BUY

80.00%

Buy

20.00%

Hold

0.00%

Sell

Based on 10 analysts, 80% of analysts recommend a 'BUY' rating for Spero Therapeutics Inc. Average target price of $4

Spero Therapeutics Inc Share Price Target

Get share price movements and forecasts by analysts on Spero Therapeutics Inc.

What analysts predicted

43.25%UPSIDE

Target Price

Current Price

$2.27

Analyzed by

10 Analysts

Target

$4.00

Spero Therapeutics Inc target price $4, a slight upside of 43.25% compared to current price of $2.27. According to 10 analysts rating.

Spero Therapeutics Inc Stock’s Investor Sentiment and Interest

Search interest for Spero Therapeutics Inc Stock has decreased by -38% in the last 30 days, reflecting a downward trend in search activity.

Time period: November 6, 2025 to December 6, 2025

Change:-38% versus previous 30 day period

Spero Therapeutics Inc Quarterly Profit & Loss

All numbers in Millions USD

	Jun 2023	Sep 2023	Dec 2023	Mar 2024	Jun 2024	Sep 2024	Dec 2024	Mar 2025	Jun 2025	Sep 2025
Total Revenue	2	25	73	4	10	13	15	5	11	3
Gross Profit	-6	24	24	4	-13	13	-79	-7	11	3
Operating Income	-12	-1	50	-13	-19	-18	-21	-14	-2	-7
EBITDA	-12	3	50	-13	-19	-18	-20	-14	-2	-7
Interest Expense	-	-	0	-	-	-	-	-	-	-
Depreciation	0	0	0	-	0	-	-	-	-	-
Income Before Tax	-11	0	51	-12	-17	-17	-20	-13	-1	-7
Income Tax Expense	0	2	0	0	-	0	0	-	-	-
Net Income	-11	-3	51	-12	-17	-17	-20	-13	-1	-7
Net Profit Margin	-438.66%	-12.58%	69.63%	-301.36%	-175.17%	-127.31%	-138.85%	-236.06%	-14.40%	-242.19%

Spero Therapeutics Inc Annual Profit & Loss

All numbers in Millions USD

	Dec 2015	Dec 2016	Dec 2017	Dec 2018	Dec 2019	Dec 2020	Dec 2021	Dec 2022	Dec 2023	Dec 2024
Total Revenue	-	0	1	3	4	9	3	48	103	47
Gross Profit	0	-25	1	3	4	9	3	48	52	-48
Operating Income	-13	-33	-41	-42	-63	-79	-87	-42	21	-73
EBITDA	-13	-32	-41	-42	-62	-78	-87	-42	27	-72
Interest Expense	-	-	0	0	-	-	1	2	-	-
Depreciation	-	-	0	0	0	0	0	0	0	0
Income Before Tax	-13	-32	-46	-41	-60	-78	-89	-46	25	-68
Income Tax Expense	-3	-7	0	1	0	0	1	1	2	-
Net Income	-10	-25	-46	-41	-60	-77	-89	-46	22	-68
Net Profit Margin	0.00%	-7609.25%	-2329.31%	-1050.48%	-1268.98%	-830.86%	-2923.65%	-95.55%	21.98%	-142.91%

Spero Therapeutics Inc Quarterly Cash Flow

All numbers in Millions USD

	Sep 2023	Dec 2023	Mar 2024	Jun 2024	Sep 2024	Dec 2024	Mar 2025	Jun 2025	Sep 2025
Net Income	-3	51	-12	-17	-17	-20	-13	-1	-7
Operating Cash Flow	15	-17	5	-18	12	-23	-4	-17	17
Investing Cash Flow	-	-	-	-	-	-	-	-	-
Financing Cash Flow	0	0	-	-	-	-	-	-	-
Change in Cash	16	-17	5	-18	12	-23	-4	-17	17

Spero Therapeutics Inc Annual Cash Flow

All numbers in Millions USD

	Dec 2016	Dec 2017	Dec 2018	Dec 2019	Dec 2020	Dec 2021	Dec 2022	Dec 2023	Dec 2024
Net Income	-32	-39	-41	-60	-78	-89	-46	22	-68
Operating Cash Flow	-28	-39	-39	-50	-85	-64	-7	-32	-23
Investing Cash Flow	0	0	-83	29	10	7	33	-	-
Financing Cash Flow	34	116	69	16	130	84	-29	0	-
Change in Cash	4	76	-53	-4	55	27	-3	-32	-23

Global Institutional Holdings in Spero Therapeutics Inc

Funds	Holdings
Pfizer Inc	4.2%
Vanguard Group Inc	3.47%
Anson Funds Management LP	2.87%
Alphabet Inc	1.58%
Renaissance Technologies Corp	1.48%

See all

Insights on Spero Therapeutics Inc

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

POSITIVE IMPACT
Price Rise
In the last 1 year, SPRO stock has moved up by 97.0%
NO EFFECT
Against Peers
In the last 1 year, Insmed Incorporated has given 172.2% return, outperforming this stock by 75.2%
NO EFFECT
Against Peers
In the last 3 years, Insmed Incorporated has given 930.9% return, outperforming this stock by 910.0%
NEGATIVE IMPACT
Profit Down
Netprofit is down for the last 2 quarters, -1.7M → -7.38M (in $), with an average decrease of 334.2% per quarter
NEGATIVE IMPACT
Revenue Fall
Revenue is down for the last 2 quarters, 11.80M → 3.04M (in $), with an average decrease of 74.2% per quarter

About Spero Therapeutics Inc

spero therapeutics is focused on the development of novel therapies to treat highly resistant bacterial infections. the culture at spero is one of respect, action, collaboration and transparency. spero team members are leaders in the field, and have the ability and desire to be a part of a team. at spero, a feeling that we are part of something groundbreaking and innovative fuels our approach.

Organisation	Spero Therapeutics Inc
Headquarters	675 Massachusetts Avenue, Cambridge, MA, United States, 02139
Industry	Health Technology
CEO	Ms. Esther P. Rajavelu
E-voting on shares	Click here to vote

Key Management of Spero Therapeutics Inc

Name	Title
Dr. Ankit Mahadevia M.D., MBA	Co-Founder & Director
Mr. Timothy Keutzer	Chief Operating Officer
Mr. John Raymond	Senior Vice President of Finance & Business Operations
Dr. David Hong	Senior Vice President of Clinical Development
Ms. Sheila Finan	Senior Vice President of Controller
Ms. Esther P. Rajavelu	CEO, CFO, President, Treasurer & Director

FAQs

What is Spero Therapeutics Inc share price today?

Spero Therapeutics Inc share price today is $2.27 as on December 6, 2025 at 2:29 am IST at the close of the market. Spero Therapeutics Inc share today touched a day high of $2.31 and a low of $2.25.

What is the 52 week high and 52 week low for Spero Therapeutics Inc share?

Spero Therapeutics Inc share touched a 52 week high of $3.22 on July 9, 2025 and a 52 week low of $0.51 on April 9, 2025. Spero Therapeutics Inc stock price today i.e. December 6, 2025 at 2:29 am IST is closed at $2.27,which is 29.50% down from its 52 week high and 349.33% up from its 52 week low.

What is Spero Therapeutics Inc's market capitalisation today?

Spero Therapeutics Inc market capitalisation is $0.00T as on December 6, 2025 at 2:29 am IST.

How to invest in Spero Therapeutics Inc Stock (SPRO) from India?

Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
Step 2: Search for Spero Therapeutics Inc on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Spero Therapeutics Inc Shares that will get you 0.6608 shares as per Spero Therapeutics Inc share price of $2.27 per share as on December 6, 2025 at 2:29 am IST.

What is the minimum amount required to buy Spero Therapeutics Inc Stock (SPRO) from India?

Indian investors can start investing in Spero Therapeutics Inc (SPRO) shares with as little as ₹89.927 or $1 (as of December 6, 2025 at 5:38 am IST) using the INDmoney app.
For example: If you want to invest $10 or ₹899.27 in Spero Therapeutics Inc stock (as per the Rupee-Dollar exchange rate as on December 6, 2025 at 5:38 am IST). Based on Spero Therapeutics Inc share’s latest price of $2.27 as on December 6, 2025 at 2:29 am IST, you will get 4.4053 shares of Spero Therapeutics Inc. Learn more about fractional shares .

What are the returns that Spero Therapeutics Inc has given to Indian investors in the last 5 years?

Spero Therapeutics Inc stock has given -86.91% share price returns and 21.87% dollar appreciation to an Indian investor in the last 5 years.
Read more about How do Currency Exchange Rates impact your returns on US Stock Investments?