Spero Therapeutics Inc Share Price

NASDAQ: SPRO

Small Cap

$1.88

-0.02

(-1.05%)

as on September 16, 2025 at 1:29 am IST

$₹

Spero Therapeutics Inc Stock Performance

as on September 16, 2025 at 1:29 am IST

Day's Low
Day's High
$1.87
Day's Price Range
$1.92
$1.88
0.53%
Downside
2.13%
Upside
52 Week's Low
52 Week's High
$0.51
52-Week Price Range
$3.22
$1.88
73.13%
Downside
71.28%
Upside

Spero Therapeutics Inc share price movements today

Previous Close: $1.90
Open: $1.91
Volume: 512.3K
Day's Low - High: $1.87 - $1.92
52 Week Low - High: $0.51 - $3.22

Spero Therapeutics Inc Historical Returns

1 Month Return: -0.52 %
3 Month Return: -32.86 %
1 Year Return: + 38.69 %
3 Year Return: + 95.88 %
5 Year Return: -80.98 %

Spero Therapeutics Inc Stock Fundamentals & Key Indicators

Check Spero Therapeutics Inc market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$106.9M

EPS (TTM)

-0.46

Dividend Yield

0.00%

Quarterly Earnings Growth YOY

0.75%

PE Ratio (TTM)

P/B Ratio

PEG Ratio

EBITDA

-56.4M

Revenue (TTM)

48.6M

Profit Margin

-110.35%

Return On Equity TTM

65866000.00%

Spero Therapeutics Inc vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Spero Therapeutics Inc with its industry peers.

Company	Analyst View	Market Cap	5 Years Return %	PE Ratio	Profit Margin %
Spero Therapeutics Inc	BUY	$106.9M	-80.98%	NA	-110.35%
Alnylam Pharmaceuticals, Inc.	BUY	$61.1B	256.98%	-505.15	-12.96%
Beone Medicines Ltd	NA	$38.7B	NA	NA	-3.89%
Vertex Pharmaceuticals Incorporated	BUY	$101.1B	47.85%	28.07	31.86%
Regeneron Pharmaceuticals, Inc.	BUY	$59.4B	-3.43%	14.11	31.37%

Stock Returns calculator for Spero Therapeutics Inc Stock including INR - Dollar returns

The Spero Therapeutics Inc stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Return is the profit earned when the US dollar rises in value compared to the Indian rupee.

Investment Value

₹1,00,000

Spero Therapeutics Inc investment value today

Current value as on today

₹1,42,212

Returns

₹42,212

(+42.21%)

Returns from Spero Therapeutics Inc Stock

₹37,226 (+37.23%)

Dollar Returns*

₹4,985 (+4.99%)

Analyst Recommendation on Spero Therapeutics Inc Stock

Based on 10 analysts

BUY

80.00%

Buy

20.00%

Hold

0.00%

Sell

Based on 10 analysts, 80% of analysts recommend a 'BUY' rating for Spero Therapeutics Inc. Average target price of $4

Spero Therapeutics Inc Share Price Target

Get share price movements and forecasts by analysts on Spero Therapeutics Inc.

What analysts predicted

53%UPSIDE

Target Price

Current Price

$1.88

Analyzed by

10 Analysts

Target

$4.00

Spero Therapeutics Inc target price $4, a slight upside of 53% compared to current price of $1.88. According to 10 analysts rating.

Spero Therapeutics Inc Stock's Interest Amongst Investors

Search interest for Spero Therapeutics Inc Stock has decreased by -47% in the last 30 days, reflecting a downward trend in search activity.

Time period: August 17, 2025 to September 16, 2025

Change:-47% versus previous 30 day period

Spero Therapeutics Inc Quarterly Profit & Loss

All numbers in Millions USD

	Mar 2023	Jun 2023	Sep 2023	Dec 2023	Mar 2024	Jun 2024	Sep 2024	Dec 2024	Mar 2025	Jun 2025
Total Revenue	0	0	25	71	4	6	13	9	5	11
Gross Profit	-8	-8	25	71	9	6	13	9	5	11
Operating Income	-14	-12	-1	50	-13	-19	-18	-21	-14	-2
EBITDA	-14	-12	0	51	-13	-19	-18	-20	-14	-2
Interest Expense	0	-	-	0	-	-	-	-	-	-
Depreciation	0	0	0	0	-	0	-	-	-	-
Income Before Tax	-13	-11	0	51	-12	-17	-17	-20	-14	-1
Income Tax Expense	0	0	-2	0	0	-	0	0	-	-
Net Income	-12	-11	-3	51	-12	-17	-17	-20	-14	-1
Net Profit Margin	-1662.84%	-1511.93%	-12.58%	71.27%	-301.36%	-296.86%	-127.31%	-223.26%	-250.78%	-14.40%

Spero Therapeutics Inc Annual Profit & Loss

All numbers in Millions USD

	Dec 2015	Dec 2016	Dec 2017	Dec 2018	Dec 2019	Dec 2020	Dec 2021	Dec 2022	Dec 2023	Dec 2024
Total Revenue	-	0	1	3	4	9	18	48	96	27
Gross Profit	0	-25	1	3	4	9	17	5	96	27
Operating Income	-13	-33	-41	-42	-63	-79	-87	-42	21	-73
EBITDA	-13	-32	-41	-42	-62	-78	-87	-42	25	-72
Interest Expense	-	-	0	0	-	-	1	2	-	-
Depreciation	-	-	0	0	0	0	0	0	0	0
Income Before Tax	-13	-32	-46	-41	-60	-78	-89	-46	25	-68
Income Tax Expense	-3	-7	0	1	0	0	1	1	2	-
Net Income	-10	-25	-46	-41	-60	-77	-89	-46	22	-68
Net Profit Margin	0.00%	-7609.25%	-2329.31%	-1050.48%	-1268.98%	-830.86%	-491.65%	-95.55%	23.58%	-250.28%

Spero Therapeutics Inc Quarterly Cash Flow

All numbers in Millions USD

	Jun 2023	Sep 2023	Dec 2023	Mar 2024	Jun 2024	Sep 2024	Dec 2024	Mar 2025	Jun 2025
Net Income	-11	-3	51	-12	-17	-17	-20	-13	-1
Operating Cash Flow	-18	15	-17	5	-18	12	-23	-4	-17
Investing Cash Flow	-	-	-	-	-	-	-	-	-
Financing Cash Flow	-	0	0	-	-	-	-	-	-
Change in Cash	-18	16	-17	5	-18	12	-23	-4	-17

Spero Therapeutics Inc Annual Cash Flow

All numbers in Millions USD

	Dec 2016	Dec 2017	Dec 2018	Dec 2019	Dec 2020	Dec 2021	Dec 2022	Dec 2023	Dec 2024
Net Income	-32	-39	-41	-60	-78	-89	-46	22	-68
Operating Cash Flow	-28	-39	-39	-50	-85	-64	-7	-32	-23
Investing Cash Flow	0	0	-83	29	10	7	33	-	-
Financing Cash Flow	34	116	69	16	130	84	-29	0	-
Change in Cash	4	76	-53	-4	55	27	-3	-32	-23

Global Institutional Holdings in Spero Therapeutics Inc

Funds	Holdings
Anson Funds Management LP	6.79%
Pfizer Inc	4.23%
Vanguard Group Inc	3.15%
Renaissance Technologies Corp	1.74%
Alphabet Inc	1.59%

See all

Insights on Spero Therapeutics Inc

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

POSITIVE IMPACT
Profit Spike
Netprofit is up for the last 3 quarters, -20.88M → -1.7M (in $), with an average increase of 404.2% per quarter
POSITIVE IMPACT
Revenue Rich
Revenue is up for the last 2 quarters, 5.87M → 11.80M (in $), with an average increase of 50.2% per quarter
NO EFFECT
Against Peers
In the last 3 years, Alnylam Pharmaceuticals, Inc. has given 118.7% return, outperforming this stock by 7.6%
NO EFFECT
Against Peers
In the last 1 year, Alnylam Pharmaceuticals, Inc. has given 72.3% return, outperforming this stock by 33.6%
NEGATIVE IMPACT
Price Dip
In the last 3 months, SPRO stock has moved down by -33.3%

About Spero Therapeutics Inc

spero therapeutics is focused on the development of novel therapies to treat highly resistant bacterial infections. the culture at spero is one of respect, action, collaboration and transparency. spero team members are leaders in the field, and have the ability and desire to be a part of a team. at spero, a feeling that we are part of something groundbreaking and innovative fuels our approach.

Organisation	Spero Therapeutics Inc
Headquarters	675 Massachusetts Avenue, Cambridge, MA, United States, 02139
Industry	Health Technology
CEO	Ms. Esther P. Rajavelu
E-voting on shares	Click here to vote

Key Management of Spero Therapeutics Inc

Name	Title
Ms. Esther P. Rajavelu	CEO, CFO, President, Treasurer & Director
Dr. Ankit Mahadevia M.D., MBA	Co-Founder & Director
Mr. Timothy Keutzer	Chief Operating Officer
Mr. John Raymond	Senior Vice President of Finance & Business Operations
Dr. David Hong	Senior Vice President of Clinical Development
Ms. Sheila Finan	Senior Vice President of Controller

FAQs

What is Spero Therapeutics Inc share price today?

Spero Therapeutics Inc share price today is $1.88 as on September 16, 2025 at 1:29 am IST at the close of the market. Spero Therapeutics Inc share today touched a day high of $1.92 and a low of $1.87.

What is the 52 week high and 52 week low for Spero Therapeutics Inc share?

Spero Therapeutics Inc share touched a 52 week high of $3.22 on July 9, 2025 and a 52 week low of $0.51 on April 9, 2025. Spero Therapeutics Inc stock price today i.e. September 16, 2025 at 1:29 am IST is closed at $1.88,which is 41.61% down from its 52 week high and 272.13% up from its 52 week low.

What is Spero Therapeutics Inc's market capitalisation today?

Spero Therapeutics Inc market capitalisation is $0.00T as on September 16, 2025 at 1:29 am IST.

How to invest in Spero Therapeutics Inc Stock (SPRO) from India?

Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
Step 2: Search for Spero Therapeutics Inc on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Spero Therapeutics Inc Shares that will get you 0.7979 shares as per Spero Therapeutics Inc share price of $1.88 per share as on September 16, 2025 at 1:29 am IST.

What is the minimum amount required to buy Spero Therapeutics Inc Stock (SPRO) from India?

Indian investors can start investing in Spero Therapeutics Inc (SPRO) shares with as little as ₹88.141 or $1 (as of September 16, 2025 at 11:40 am IST) using the INDmoney app.
For example: If you want to invest $10 or ₹881.41 in Spero Therapeutics Inc stock (as per the Rupee-Dollar exchange rate as on September 16, 2025 at 11:40 am IST). Based on Spero Therapeutics Inc share’s latest price of $1.88 as on September 16, 2025 at 1:29 am IST, you will get 5.3191 shares of Spero Therapeutics Inc. Learn more about fractional shares .

What are the returns that Spero Therapeutics Inc has given to Indian investors in the last 5 years?

Spero Therapeutics Inc stock has given -80.98% share price returns and 20.01% dollar appreciation to an Indian investor in the last 5 years.
Read more about How do Currency Exchange Rates impact your returns on US Stock Investments?