Spero Therapeutics Inc share price logo

Spero Therapeutics Inc Share Price

NASDAQ: SPRO

Small Cap

$2.79

-0.05

(-1.94%)

Live

as on

Spero Therapeutics Inc Stock Performance

as on April 22, 2026 at 3:12 am IST

  • Day's Low

    Day's High

    $2.74
    $2.82
    downward going graph

    1.79%

    Downside

    1.08%

    Upside

    downward going graph
  • 52 Week's Low

    52 Week's High

    $0.57
    $3.22
    downward going graph

    79.57%

    Downside

    15.41%

    Upside

    downward going graph

Spero Therapeutics Inc share price movements today

Previous Close
$2.84
Open
$2.82
Volume
231.9K
Day's Low - High
$2.74 - $2.82
52 Week Low - High
$0.57 - $3.22

Spero Therapeutics Inc Historical Returns

1 Month Return
+ 19.83 %
3 Month Return
+ 20.34 %
1 Year Return
+ 291.72 %
3 Year Return
+ 67.06 %
5 Year Return
-78.65 %

Spero Therapeutics Inc Stock Fundamentals & Key Indicators

Check Spero Therapeutics Inc market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$159.2M

EPS (TTM)

0.67

Dividend Yield

0.00%

Quarterly Earnings Growth YOY

0.75%

PE Ratio (TTM)

18.33

Industry PE ratio

-3.3351693002257337

PEG Ratio

0

EBITDA

7.2M

Revenue (TTM)

66.8M

Profit Margin

12.83%

Return On Equity TTM

16.31%

Spero Therapeutics Inc Stock Valuation

Track how Spero Therapeutics Inc P/E has moved over time to understand its valuation trends.

Spero Therapeutics Inc in the last 5 years

  • Overview

  • Trends

Lowest (-6.58x)

June 30, 2023

Industry (-3.34x)

April 21, 2026

Today (18.33x)

April 21, 2026

Highest (19.15x)

September 30, 2024

LowHigh

Today’s Price to Earnings Ratio: 18.33x

Spero Therapeutics Inc vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Spero Therapeutics Inc with its industry peers.

Company
Analyst View
Market Cap
5 Years Return %PE RatioProfit Margin %
BUY$159.2M-78.65%18.3312.83%
BUY$41.3B126.09%133.478.45%
BUY$111.7B99.85%28.6532.94%
NA$36.5BNA128.255.37%
BUY$79.2B47.96%18.0531.41%

Stock Returns calculator for Spero Therapeutics Inc Stock including INR - Dollar returns

The Spero Therapeutics Inc stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Impact: The bonus return you make when the US Dollar rises against the Rupee; calculated on the full amount you walk away with, not just what you invested in.

Investment Value

₹1,00,000

  • 1Y

  • 3Y

  • 5Y

  • 7Y

Spero Therapeutics Inc investment value today

Current value as on today

₹4,25,372

Returns

₹3,25,372

(+325.37%)

Returns from Spero Therapeutics Inc Stock

₹2,87,500 (+287.5%)

Dollar Impact

₹37,872 (+37.87%)

Analyst Recommendation on Spero Therapeutics Inc Stock

Based on 10 analysts

BUY

80.00%

Buy

20.00%

Hold

0.00%

Sell

Based on 10 analysts, 80% of analysts recommend a 'BUY' rating for Spero Therapeutics Inc. Average target price of $4

Spero Therapeutics Inc Share Price Target

Get share price movements and forecasts by analysts on Spero Therapeutics Inc.

What analysts predicted

30.25%UPSIDE

Target Price

$4

Current Price

$2.79

Analyzed by

10 Analysts

Target

$4.00

Spero Therapeutics Inc target price $4, a slight upside of 30.25% compared to current price of $2.79. According to 10 analysts rating.

Spero Therapeutics Inc Stock’s Investor Sentiment and Interest

Search interest for Spero Therapeutics Inc Stock has decreased by -43% in the last 30 days, reflecting a downward trend in search activity.

Time period: to

Change:-43% versus previous 30 day period

Spero Therapeutics Inc Quarterly Profit & Loss

All numbers in Millions USD

Sep 2023
Dec 2023
Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Total Revenue
25
73
4
10
13
15
5
11
3
39
Gross Profit
24
24
4
-13
13
-79
-7
11
3
39
Operating Income
-1
50
-13
-19
-18
-21
-14
-2
-7
25
EBITDA
3
50
-13
-19
-18
-20
-14
-2
-7
29
Interest Expense
-
0
-
-
-
-
-
-
-
-
Depreciation
0
0
-
0
-
-
-
-
-
-
Income Before Tax
0
51
-12
-17
-17
-20
-13
-1
-7
31
Income Tax Expense
2
0
0
-
0
0
-
-
-
0
Net Income
-3
51
-12
-17
-17
-20
-13
-1
-7
31
Net Profit Margin
-12.58%
69.63%
-301.36%
-175.17%
-127.31%
-138.85%
-236.06%
-14.40%
-242.19%
79.48%

Spero Therapeutics Inc Annual Profit & Loss

All numbers in Millions USD

Dec 2016
Dec 2017
Dec 2018
Dec 2019
Dec 2020
Dec 2021
Dec 2022
Dec 2023
Dec 2024
Dec 2025
Total Revenue
0
1
3
4
9
3
48
103
47
59
Gross Profit
-25
1
3
4
9
3
48
52
-48
59
Operating Income
-33
-41
-42
-63
-79
-87
-42
21
-73
0
EBITDA
-32
-41
-42
-62
-78
-87
-42
27
-72
0
Interest Expense
-
0
0
-
-
1
2
-
-
-
Depreciation
-
0
0
0
0
0
0
0
0
-
Income Before Tax
-32
-46
-41
-60
-78
-89
-46
25
-68
8
Income Tax Expense
-7
0
1
0
0
1
1
2
-
0
Net Income
-25
-46
-41
-60
-77
-89
-46
22
-68
8
Net Profit Margin
-7609.25%
-2329.31%
-1050.48%
-1268.98%
-830.86%
-2923.65%
-95.55%
21.98%
-142.91%
14.38%

Spero Therapeutics Inc Quarterly Cash Flow

All numbers in Millions USD

Dec 2023
Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Net Income
51
-12
-17
-17
-20
-13
-1
-7
31
Operating Cash Flow
-17
5
-18
12
-23
-4
-17
17
-8
Investing Cash Flow
-
-
-
-
-
-
-
-
-
Financing Cash Flow
0
-
-
-
-
-
-
-
-
Change in Cash
-17
5
-18
12
-23
-4
-17
17
-8

Spero Therapeutics Inc Annual Cash Flow

All numbers in Millions USD

Dec 2017
Dec 2018
Dec 2019
Dec 2020
Dec 2021
Dec 2022
Dec 2023
Dec 2024
Dec 2025
Net Income
-39
-41
-60
-78
-89
-46
22
-68
8
Operating Cash Flow
-39
-39
-50
-85
-64
-7
-32
-23
-12
Investing Cash Flow
0
-83
29
10
7
33
-
-
-
Financing Cash Flow
116
69
16
130
84
-29
0
-
-
Change in Cash
76
-53
-4
55
27
-3
-32
-23
-12

Global Institutional Holdings in Spero Therapeutics Inc

Funds
Holdings
Squarepoint Ops LLC
0.21%
Alphabet Inc
1.58%
Schonfeld Strategic Advisors LLC
0.91%
ADAR1 Capital Management LLC
0.2%
BlackRock Inc
0.77%

Insights on Spero Therapeutics Inc

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

  • imgPOSITIVE IMPACT

    Best in 1 Year

    img

    In the last 1 year, SPRO has outperformed top 5 stocks with highest market-cap in its industry

  • imgPOSITIVE IMPACT

    Profit Spike

    img

    Netprofit is up for the last 2 quarters, -7.38M → 31.52M (in $), with an average increase of 123.4% per quarter

  • imgPOSITIVE IMPACT

    Price Rise

    img

    In the last 1 year, SPRO stock has moved up by 291.7%

  • imgPOSITIVE IMPACT

    Revenue Rich

    img

    Revenue is up for the last 2 quarters, 3.04M → 39.65M (in $), with an average increase of 92.3% per quarter

  • imgPOSITIVE IMPACT

    Best in 3 Years

    img

    In the last 3 years, SPRO has outperformed top 5 stocks with highest market-cap in its industry

About Spero Therapeutics Inc

Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying and developing novel treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include Tebipenem HBr (tebipenem pivoxil hydrobromide), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adult patients, which is in Phase 3 development; and SPR720, a novel product candidate for first-line treatment of nontuberculous mycobacterial (NTM) pulmonary disease. It has license agreement with Meiji Seika Pharma Co., Ltd. to support the development of tebipenem HBr; Everest Medicines to develop, manufacture, and commercialize SPR206 in Greater China, South Korea, and Southeast Asian countries; and Vertex Pharmaceuticals Incorporated for patents relating to the oral prodrug SPR720, as well as SPR719, an active metabolite. Spero Therapeutics, Inc. was founded in 2013 and is headquartered in Cambridge, Massachusetts.
OrganisationSpero Therapeutics Inc
Headquarters675 Massachusetts Avenue, Cambridge, MA, United States, 02139
IndustryBiotechnology
CEOMs. Esther P. Rajavelu
E-voting on sharesClick here to vote

Key Management of Spero Therapeutics Inc

Name

Title

Ms. Sheila Finan

Senior Vice President of Controller

Ms. Esther P. Rajavelu

CEO, President, CFO, Chief Business Officer, Treasurer & Director

Mr. Timothy Keutzer

Chief Operating Officer

Mr. John Raymond

Senior Vice President of Finance & Business Operations

FAQs

What is Spero Therapeutics Inc share price today?

Spero Therapeutics Inc share price today is $2.79 as on . Spero Therapeutics Inc share today touched a day high of $2.82 and a low of $2.74.

What is the 52 week high and 52 week low for Spero Therapeutics Inc share?

Spero Therapeutics Inc share touched a 52 week high of $3.22 on and a 52 week low of $0.57 on . Spero Therapeutics Inc stock price today i.e. is trending at $2.79,which is 13.35% down from its 52 week high and 389.47% up from its 52 week low.

What is Spero Therapeutics Inc's market capitalisation today?

Spero Therapeutics Inc market capitalisation is $0.00T as on .

How to invest in Spero Therapeutics Inc Stock (SPRO) from India?

  1. Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
  2. Step 2: Search for Spero Therapeutics Inc on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Spero Therapeutics Inc Shares that will get you 0.5376 shares as per Spero Therapeutics Inc share price of $2.79 per share as on April 21, 2026 at 9:42 pm IST.

What is the minimum amount required to buy Spero Therapeutics Inc Stock (SPRO) from India?

Indian investors can start investing in Spero Therapeutics Inc (SPRO) shares with as little as ₹93.505 or $1 (as of ) using the INDmoney app.
For example: If you want to invest $10 or ₹935.05 in Spero Therapeutics Inc stock (as per the Rupee-Dollar exchange rate as on ). Based on Spero Therapeutics Inc share’s latest price of $2.79 as on April 21, 2026 at 9:42 pm IST, you will get 3.5842 shares of Spero Therapeutics Inc. Learn more about fractional shares .

What are the returns that Spero Therapeutics Inc has given to Indian investors in the last 5 years?

Spero Therapeutics Inc stock has given -78.65% share price returns and 22.82% dollar appreciation to an Indian investor in the last 5 years.
Read more about How do Currency Exchange Rates impact your returns on US Stock Investments?