Spero Therapeutics Inc. share price logo

Spero Therapeutics Inc.

NASDAQ: SPRO

$2.18

+0.08

(+3.81%)

as on

Spero Therapeutics Inc. Stock Performance

as on July 14, 2026 at 2:15 pm IST

  • Day's Low

    Day's High

    $2.07
    $2.19
    downward going graph

    5.05%

    Downside

    0.46%

    Upside

    downward going graph

  • 52 Week's Low

    52 Week's High

    $1.80
    $3.08
    downward going graph

    17.43%

    Downside

    41.28%

    Upside

    downward going graph

Spero Therapeutics Inc. share price movements today

Previous Close
$2.10
Open
$2.11
Volume
1.0M
Day's Low - High
$2.07 - $2.19
52 Week Low - High
$1.80 - $3.08

Spero Therapeutics Inc. Historical Returns

1 Month Return
-23.51 %
3 Month Return
-21.58 %
1 Year Return
-17.42 %
3 Year Return
+ 44.37 %
5 Year Return
-84.74 %

Spero Therapeutics Inc. Stock Fundamentals & Key Indicators

Check Spero Therapeutics Inc. market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$121.6M

EPS (TTM)

-0.29

Dividend Yield

0.00%

Quarterly Earnings Growth YOY

0.75%

PE Ratio (TTM)

7.78

Industry PE ratio

-2.8228518518518517

PEG Ratio

0

EBITDA

7.2M

Revenue (TTM)

61.2M

Profit Margin

24.90%

Return On Equity TTM

35.13%

Spero Therapeutics Inc. Stock Valuation

Track how Spero Therapeutics Inc. P/E has moved over time to understand its valuation trends.

Spero Therapeutics Inc. in the last 5 years

  • Overview

  • Trends

Lowest (-6.58x)

June 30, 2023

Industry (-2.82x)

July 14, 2026

Today (7.78x)

July 14, 2026

Highest (19.15x)

September 30, 2024

LowHigh

Today’s Price to Earnings Ratio: 7.78x

Spero Therapeutics Inc. vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Spero Therapeutics Inc. with its industry peers.

Company
Analyst View
Market Cap
5 Years Return %PE RatioProfit Margin %Dividend Yield %
Spero Therapeutics Inc. image
Spero Therapeutics Inc.
BUY$121.6M-84.74%7.7824.90%NA
Alnylam Pharmaceuticals Inc. image
Alnylam Pharmaceuticals Inc.
BUY$39.9B69.11%75.2512.55%NA
Vertex Pharmaceuticals Inc. image
Vertex Pharmaceuticals Inc.
BUY$123.2B142.69%28.8235.51%NA
Regeneron Pharmaceuticals Inc. image
Regeneron Pharmaceuticals Inc.
BUY$69.7B14.12%16.2429.65%0.54%

Stock Returns calculator for Spero Therapeutics Inc. Stock including INR - Dollar returns

The Spero Therapeutics Inc. stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Impact: The bonus return you make when the US Dollar rises against the Rupee; calculated on the full amount you walk away with, not just what you invested in.

Investment Value

₹1,00,000

  • 1Y

  • 3Y

  • 5Y

  • 7Y

Spero Therapeutics Inc. investment value today

Current value as on today

₹91,790

Returns

-₹8,210

(-8.21%)

Returns from Spero Therapeutics Inc. Stock

-₹17,424 (-17.42%)

Dollar Impact

₹9,215 (+9.21%)

Analyst Recommendation on Spero Therapeutics Inc. Stock

Based on 10 analysts

BUY

80.00%

Buy

20.00%

Hold

0.00%

Sell

Based on 10 analysts, 80% of analysts recommend a 'BUY' rating for Spero Therapeutics Inc.. Average target price of $4

Spero Therapeutics Inc. Share Price Target

Get share price movements and forecasts by analysts on Spero Therapeutics Inc..

What analysts predicted

45.5%UPSIDE

Target Price

$4

Current Price

$2.18

Analyzed by

10 Analysts

Target

$4.00

Spero Therapeutics Inc. target price $4, a slight upside of 45.5% compared to current price of $2.18. According to 10 analysts rating.

Indian Investors' Interest in Spero Therapeutics Inc. Stock

Search interest for Spero Therapeutics Inc. Stock has increased by 726% in the last 30 days, reflecting an upward trend in search activity.

Time period: to

Change:726% versus previous 30 day period

Spero Therapeutics Inc. Quarterly Profit & Loss

All numbers in Millions USD

Dec 2023
Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Mar 2026
Total Revenue
73
4
10
13
15
5
11
3
39
0
Gross Profit
24
4
-13
13
-79
-7
11
3
39
0
Operating Income
50
-13
-19
-18
-21
-14
-2
-7
31
-7
EBITDA
51
-12
-17
-17
-20
-14
-2
-7
31
-7
Interest Expense
0
-
-
-
-
-
-
-
-
-
Depreciation
0
-
0
-
-
-
-
-
-
-
Income Before Tax
51
-12
-17
-17
-20
-13
-1
-7
31
-7
Income Tax Expense
0
0
-
0
0
-
-
-
0
-
Net Income
51
-12
-17
-17
-20
-13
-1
-7
31
-7
Net Profit Margin
69.63%
-301.36%
-175.17%
-127.31%
-138.85%
-236.06%
-14.40%
-242.19%
79.48%
-2791.86%

Spero Therapeutics Inc. Annual Profit & Loss

All numbers in Millions USD

Dec 2016
Dec 2017
Dec 2018
Dec 2019
Dec 2020
Dec 2021
Dec 2022
Dec 2023
Dec 2024
Dec 2025
Total Revenue
0
1
3
4
9
3
48
103
47
59
Gross Profit
-25
1
3
4
9
3
48
52
-48
59
Operating Income
-33
-41
-42
-63
-79
-87
-42
21
-73
0
EBITDA
-32
-41
-42
-62
-78
-87
-42
27
-72
8
Interest Expense
-
0
0
-
-
1
2
-
-
-
Depreciation
-
0
0
0
0
0
0
0
0
-
Income Before Tax
-32
-46
-41
-60
-78
-89
-46
25
-68
8
Income Tax Expense
-7
0
1
0
0
1
1
2
-
0
Net Income
-25
-46
-41
-60
-77
-89
-46
22
-68
8
Net Profit Margin
-7609.25%
-2329.31%
-1050.48%
-1268.98%
-830.86%
-2923.65%
-95.55%
21.98%
-142.91%
14.38%

Spero Therapeutics Inc. Quarterly Cash Flow

All numbers in Millions USD

Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Sep 2025
Dec 2025
Mar 2026
Net Income
-12
-17
-17
-20
-13
-1
-7
31
-7
Operating Cash Flow
5
-18
12
-23
-4
-17
17
-8
15
Investing Cash Flow
-
-
-
-
-
-
-
-
-
Financing Cash Flow
-
-
-
-
-
-
-
-
-
Change in Cash
5
-18
12
-23
-4
-17
17
-8
15

Spero Therapeutics Inc. Annual Cash Flow

All numbers in Millions USD

Dec 2017
Dec 2018
Dec 2019
Dec 2020
Dec 2021
Dec 2022
Dec 2023
Dec 2024
Dec 2025
Net Income
-39
-41
-60
-78
-89
-46
22
-68
8
Operating Cash Flow
-39
-39
-50
-85
-64
-7
-32
-23
-12
Investing Cash Flow
0
-83
29
10
7
33
-
-
-
Financing Cash Flow
116
69
16
130
84
-29
0
-
-
Change in Cash
76
-53
-4
55
27
-3
-32
-23
-12

Global Institutional Holdings in Spero Therapeutics Inc.

Funds
Holdings
Vanguard Capital Management, LLC
3.11%
Schonfeld Strategic Advisors LLC
0.91%
Anson Funds Management LP
1.46%
ADAR1 Capital Management LLC
0.2%
Susquehanna International Group, LLP
0.58%
See all

Insights on Spero Therapeutics Inc.

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

  • imgPOSITIVE IMPACT

    Best in 3 Years

    img

    In the last 3 years, SPRO has outperformed top 5 stocks with highest market-cap in its industry

  • imgNO EFFECT

    Against Peers

    img

    In the last 1 year, Regeneron Pharmaceuticals, Inc. Common Stock has given 16.5% return, outperforming this stock by 37.0%

  • imgNEGATIVE IMPACT

    Profit Down

    img

    Netprofit is down for the last 2 quarters, 31.52M → -7.20M (in $), with an average decrease of 122.9% per quarter

  • imgNEGATIVE IMPACT

    Revenue Fall

    img

    Revenue is down for the last 2 quarters, 39.65M → 258.0K (in $), with an average decrease of 99.4% per quarter

  • imgNEGATIVE IMPACT

    Price Dip

    img

    In the last 1 month, SPRO stock has moved down by -26.3%

About Spero Therapeutics Inc.

Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying and developing novel treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include Tebipenem HBr (tebipenem pivoxil hydrobromide), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adult patients, which has completed second Phase 3 trial. It has license agreement with Meiji Seika Pharma Co., Ltd. to develop, manufacture, and commercialize tebipenem pivoxil and tebipenem HBr; and Everest Medicines to develop, manufacture, and commercialize SPR206 in Greater China, South Korea, and Southeast Asian countries. Spero Therapeutics, Inc. was incorporated in 2013 and is headquartered in Cambridge, Massachusetts.
OrganisationSpero Therapeutics Inc.
Headquarters675 Massachusetts Avenue, Cambridge, MA, United States, 02139
IndustryBiotechnology
CEOMs. Esther P. Rajavelu
E-voting on sharesClick here to vote

Key Management of Spero Therapeutics Inc.

Name

Title

Mr. Timothy Keutzer

Chief Operating Officer

Mr. John Raymond

Senior Vice President of Finance & Business Operations

Ms. Sheila Finan

Senior VP & Controller

Ms. Esther P. Rajavelu

CEO, President, CFO, Chief Business Officer, Treasurer & Director

FAQs

What is Spero Therapeutics Inc. share price today?

Spero Therapeutics Inc. share price today is $2.18 as on at the close of the market. Spero Therapeutics Inc. share today touched a day high of $2.19 and a low of $2.07.

What is the 52 week high and 52 week low for Spero Therapeutics Inc. share?

Spero Therapeutics Inc. share touched a 52 week high of $3.08 on and a 52 week low of $1.80 on . Spero Therapeutics Inc. stock price today i.e. is closed at $2.18,which is 29.22% down from its 52 week high and 21.11% up from its 52 week low.

What is Spero Therapeutics Inc.'s market capitalisation today?

Spero Therapeutics Inc. market capitalisation is $0.00T as on .

How to invest in Spero Therapeutics Inc. Stock (SPRO) from India?

  1. Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
  2. Step 2: Search for Spero Therapeutics Inc. on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Spero Therapeutics Inc. Shares that will get you 0.6881 shares as per Spero Therapeutics Inc. share price of $2.18 per share as on July 14, 2026 at 8:45 am IST.

What is the minimum amount required to buy Spero Therapeutics Inc. Stock (SPRO) from India?

Indian investors can start investing in Spero Therapeutics Inc. (SPRO) shares with as little as ₹95.615 or $1 (as of ) using the INDmoney app.
For example: If you want to invest $10 or ₹956.15 in Spero Therapeutics Inc. stock (as per the Rupee-Dollar exchange rate as on ). Based on Spero Therapeutics Inc. share’s latest price of $2.18 as on July 14, 2026 at 8:45 am IST, you will get 4.5872 shares of Spero Therapeutics Inc.. Learn more about fractional shares .

What are the returns that Spero Therapeutics Inc. has given to Indian investors in the last 5 years?

Spero Therapeutics Inc. stock has given -84.74% share price returns and 27.79% dollar appreciation to an Indian investor in the last 5 years.
Read more about How do Currency Exchange Rates impact your returns on US Stock Investments?