Spero Therapeutics Inc. (SPRO) Live Share Price, Invest From India

Spero Therapeutics Inc. Stock Performance

as on August 4, 2026 at 2:16 pm IST

Day's Low
Day's High
$1.12
Day's Price Range
$1.22
$1.15
2.61%
Downside
6.09%
Upside
52 Week's Low
52 Week's High
$1.08
52-Week Price Range
$3.08
$1.15
6.09%
Downside
167.83%
Upside

Spero Therapeutics Inc. share price movements today

Previous Close: $1.17
Open: $1.18
Volume: 1.5M
Day's Low - High: $1.12 - $1.22
52 Week Low - High: $1.08 - $3.08

Spero Therapeutics Inc. Historical Returns

1 Month Return: -47.73 %
3 Month Return: -54 %
1 Year Return: -49.12 %
3 Year Return: -23.84 %
5 Year Return: -91.59 %

Spero Therapeutics Inc. Stock Fundamentals & Key Indicators

Check Spero Therapeutics Inc. market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$67.7M

EPS (TTM)

-0.29

Dividend Yield

0.00%

Quarterly Earnings Growth YOY

0.75%

PE Ratio (TTM)

4.33

Industry PE ratio

-2.8024378109452734

PEG Ratio

EBITDA

7.2M

Revenue (TTM)

61.2M

Profit Margin

24.90%

Return On Equity TTM

35.13%

Spero Therapeutics Inc. Stock Valuation

Track how Spero Therapeutics Inc. P/E has moved over time to understand its valuation trends.

Spero Therapeutics Inc. in the last 5 years

Overview
Trends

Lowest (-6.58x)

June 30, 2023

Industry (-2.80x)

August 4, 2026

Today (4.33x)

August 4, 2026

Highest (30.70x)

June 30, 2026

LowHigh

Today’s Price to Earnings Ratio: 4.33x

Spero Therapeutics Inc. vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Spero Therapeutics Inc. with its industry peers.

Company	Analyst View	Market Cap	5 Years Return %	PE Ratio	Profit Margin %	Dividend Yield %
Spero Therapeutics Inc.	BUY	$67.7M	-91.59%	4.33	24.90%	NA
Revolution Medicines Inc.	BUY	$39.9B	561.77%	NA	0.00%	NA
Vertex Pharmaceuticals Inc.	BUY	$121.1B	135.84%	28.33	35.51%	NA
Regeneron Pharmaceuticals Inc.	BUY	$78.5B	30.69%	18.87	27.87%	0.49%

Stock Returns calculator for Spero Therapeutics Inc. Stock including INR - Dollar returns

The Spero Therapeutics Inc. stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Impact: The bonus return you make when the US Dollar rises against the Rupee; calculated on the full amount you walk away with, not just what you invested in.

Investment Value

₹1,00,000

Spero Therapeutics Inc. investment value today

Current value as on today

₹55,352

Returns

-₹44,648

(-44.65%)

Returns from Spero Therapeutics Inc. Stock

-₹49,115 (-49.12%)

Dollar Impact

₹4,467 (+4.47%)

Analyst Recommendation on Spero Therapeutics Inc. Stock

Based on 10 analysts

BUY

80.00%

Buy

20.00%

Hold

0.00%

Sell

Based on 10 analysts, 80% of analysts recommend a 'BUY' rating for Spero Therapeutics Inc.. Average target price of $4

Spero Therapeutics Inc. Share Price Target

Get share price movements and forecasts by analysts on Spero Therapeutics Inc..

What analysts predicted

71.25%UPSIDE

Target Price

Current Price

$1.15

Analyzed by

10 Analysts

Target

$4.00

Spero Therapeutics Inc. target price $4, a slight upside of 71.25% compared to current price of $1.15. According to 10 analysts rating.

Indian Investors' Interest in Spero Therapeutics Inc. Stock

Search interest for Spero Therapeutics Inc. Stock has decreased by -76% in the last 30 days, reflecting a downward trend in search activity.

Time period: July 5, 2026 to August 4, 2026

Change:-76% versus previous 30 day period

Spero Therapeutics Inc. Quarterly Profit & Loss

All numbers in Millions USD

	Dec 2023	Mar 2024	Jun 2024	Sep 2024	Dec 2024	Mar 2025	Jun 2025	Sep 2025	Dec 2025	Mar 2026
Total Revenue	73	4	10	13	15	5	11	3	39	0
Gross Profit	24	4	-13	13	-79	-7	11	3	39	0
Operating Income	50	-13	-19	-18	-21	-14	-2	-7	31	-7
EBITDA	51	-12	-17	-17	-20	-14	-2	-7	31	-7
Interest Expense	0	-	-	-	-	-	-	-	-	-
Depreciation	0	-	0	-	-	-	-	-	-	-
Income Before Tax	51	-12	-17	-17	-20	-13	-1	-7	31	-7
Income Tax Expense	0	0	-	0	0	-	-	-	0	-
Net Income	51	-12	-17	-17	-20	-13	-1	-7	31	-7
Net Profit Margin	69.63%	-301.36%	-175.17%	-127.31%	-138.85%	-236.06%	-14.40%	-242.19%	79.48%	-2791.86%

Spero Therapeutics Inc. Annual Profit & Loss

All numbers in Millions USD

	Dec 2016	Dec 2017	Dec 2018	Dec 2019	Dec 2020	Dec 2021	Dec 2022	Dec 2023	Dec 2024	Dec 2025
Total Revenue	0	1	3	4	9	3	48	103	47	59
Gross Profit	-25	1	3	4	9	3	48	52	-48	59
Operating Income	-33	-41	-42	-63	-79	-87	-42	21	-73	0
EBITDA	-32	-41	-42	-62	-78	-87	-42	27	-72	8
Interest Expense	-	0	0	-	-	1	2	-	-	-
Depreciation	-	0	0	0	0	0	0	0	0	-
Income Before Tax	-32	-46	-41	-60	-78	-89	-46	25	-68	8
Income Tax Expense	-7	0	1	0	0	1	1	2	-	0
Net Income	-25	-46	-41	-60	-77	-89	-46	22	-68	8
Net Profit Margin	-7609.25%	-2329.31%	-1050.48%	-1268.98%	-830.86%	-2923.65%	-95.55%	21.98%	-142.91%	14.38%

Spero Therapeutics Inc. Quarterly Cash Flow

All numbers in Millions USD

	Mar 2024	Jun 2024	Sep 2024	Dec 2024	Mar 2025	Jun 2025	Sep 2025	Dec 2025	Mar 2026
Net Income	-12	-17	-17	-20	-13	-1	-7	31	-7
Operating Cash Flow	5	-18	12	-23	-4	-17	17	-8	15
Investing Cash Flow	-	-	-	-	-	-	-	-	-
Financing Cash Flow	-	-	-	-	-	-	-	-	-
Change in Cash	5	-18	12	-23	-4	-17	17	-8	15

Spero Therapeutics Inc. Annual Cash Flow

All numbers in Millions USD

	Dec 2017	Dec 2018	Dec 2019	Dec 2020	Dec 2021	Dec 2022	Dec 2023	Dec 2024	Dec 2025
Net Income	-39	-41	-60	-78	-89	-46	22	-68	8
Operating Cash Flow	-39	-39	-50	-85	-64	-7	-32	-23	-12
Investing Cash Flow	0	-83	29	10	7	33	-	-	-
Financing Cash Flow	116	69	16	130	84	-29	0	-	-
Change in Cash	76	-53	-4	55	27	-3	-32	-23	-12

Global Institutional Holdings in Spero Therapeutics Inc.

Funds	Holdings
Anson Funds Management LP	1.46%
Schonfeld Strategic Advisors LLC	0.91%
Susquehanna International Group, LLP	0.58%
ADAR1 Capital Management LLC	0.2%
Ionic Capital Management LLC	0.34%

See all

Insights on Spero Therapeutics Inc.

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

NO EFFECT
Against Peers
In the last 1 year, Revolution Medicines, Inc. Common Stock has given 390.7% return, outperforming this stock by 439.8%
NO EFFECT
Against Peers
In the last 3 years, Revolution Medicines, Inc. Common Stock has given 484.6% return, outperforming this stock by 508.4%
NEGATIVE IMPACT
Price Dip
In the last 1 month, SPRO stock has moved down by -47.7%
NEGATIVE IMPACT
Profit Down
Netprofit is down for the last 2 quarters, 31.52M → -7.20M (in $), with an average decrease of 122.9% per quarter
NEGATIVE IMPACT
Revenue Fall
Revenue is down for the last 2 quarters, 39.65M → 258.0K (in $), with an average decrease of 99.4% per quarter

About Spero Therapeutics Inc.

Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying and developing novel treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include Tebipenem HBr (tebipenem pivoxil hydrobromide), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adult patients, which has completed second Phase 3 trial. It has license agreement with Meiji Seika Pharma Co., Ltd. to develop, manufacture, and commercialize tebipenem pivoxil and tebipenem HBr; and Everest Medicines to develop, manufacture, and commercialize SPR206 in Greater China, South Korea, and Southeast Asian countries. Spero Therapeutics, Inc. was incorporated in 2013 and is headquartered in Cambridge, Massachusetts.

Organisation	Spero Therapeutics Inc.
Headquarters	675 Massachusetts Avenue, Cambridge, MA, United States, 02139
Industry	Biotechnology
CEO	Ms. Esther P. Rajavelu
E-voting on shares	Click here to vote

Key Management of Spero Therapeutics Inc.

Name	Title
Dr. Debra Jeske Zack M.D., Ph.D.	Chief Medical Officer
Ms. Sheila Finan	Senior VP & Controller
Ms. Esther P. Rajavelu	CEO, President, CFO, Chief Business Officer, Treasurer & Director
Mr. Timothy Keutzer	Chief Operating Officer
Mr. John Raymond	Senior Vice President of Finance & Business Operations

FAQs

What is Spero Therapeutics Inc. share price today?

Spero Therapeutics Inc. share price today is $1.15 as on August 4, 2026 at 8:46 am IST at the close of the market. Spero Therapeutics Inc. share today touched a day high of $1.22 and a low of $1.12.

What is the 52 week high and 52 week low for Spero Therapeutics Inc. share?

Spero Therapeutics Inc. share touched a 52 week high of $3.08 on May 27, 2026 and a 52 week low of $1.08 on July 24, 2026. Spero Therapeutics Inc. stock price today i.e. August 4, 2026 at 8:46 am IST is closed at $1.15,which is 62.66% down from its 52 week high and 6.48% up from its 52 week low.

What is Spero Therapeutics Inc.'s market capitalisation today?

Spero Therapeutics Inc. market capitalisation is $0.00T as on August 4, 2026 at 8:46 am IST.

How to invest in Spero Therapeutics Inc. Stock (SPRO) from India?

Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
Step 2: Search for Spero Therapeutics Inc. on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Spero Therapeutics Inc. Shares that will get you 1.3043 shares as per Spero Therapeutics Inc. share price of $1.15 per share as on August 4, 2026 at 8:46 am IST.

What is the minimum amount required to buy Spero Therapeutics Inc. Stock (SPRO) from India?

Indian investors can start investing in Spero Therapeutics Inc. (SPRO) shares with as little as ₹95.3775 or $1 (as of August 4, 2026 at 6:43 pm IST) using the INDmoney app.
For example: If you want to invest $10 or ₹953.77 in Spero Therapeutics Inc. stock (as per the Rupee-Dollar exchange rate as on August 4, 2026 at 6:43 pm IST). Based on Spero Therapeutics Inc. share’s latest price of $1.15 as on August 4, 2026 at 8:46 am IST, you will get 8.6957 shares of Spero Therapeutics Inc.. Learn more about fractional shares .

What are the returns that Spero Therapeutics Inc. has given to Indian investors in the last 5 years?

Spero Therapeutics Inc. stock has given -91.59% share price returns and 28.53% dollar appreciation to an Indian investor in the last 5 years.
Read more about How do Currency Exchange Rates impact your returns on US Stock Investments?