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Oncternal Therapeutics Inc
Oncternal Therapeutics Inc
ONCT

Oncternal Therapeutics Inc (ONCT)

$3.6413.95%

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Key Stats

Open
$3.68
Today Low/High
$3.62 / $3.74
52 Week Low/High
$1.49 / $10.56
P/E ratio
-8.374
Market Cap
$172.35M

Company Details

Oncternal Therapeutics is a clinical-stage biopharmaceutical company focused on the development of novel oncology therapies for the treatment of cancers with critical unmet medical need. Oncternal focuses drug development on promising yet untapped biological pathways implicated in cancer generation or progression. The clinical pipeline includes cirmtuzumab, an investigational monoclonal antibody designed to inhibit the ROR1 pathway, a type I tyrosine kinase-like orphan receptor, that is being evaluated in a Phase 1/2 clinical trial in combination with ibrutinib for the treatment of patients with mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL) and in an investigator-sponsored, Phase 1b clinical trial in combination with paclitaxel for the treatment of women with HER2-negative metastatic or locally advanced, unresectable breast cancer. The clinical pipeline also includes TK216, an investigational targeted small-molecule inhibitor of the ETS family of oncoproteins, that is being evaluated in a Phase 1 clinical trial for patients with Ewing sarcoma alone and in combination with vincristine chemotherapy. In addition, Oncternal has a program utilizing the cirmtuzumab antibody backbone to develop a CAR-T therapy that targets ROR1, which is currently in preclinical development as a potential treatment for hematologic cancers and solid tumors.
Organisation
Oncternal Therapeutics Inc
Headquaters
San Diego, California, US
Employees
13
Industry
Biotechnology
CEO
James Breitmeyer

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