Spyre Therapeutics Inc Stock Performance
as on November 14, 2025 at 2:29 am IST
Day's Low
Day's High
$22.47$23.57
0.75%
Downside
4.11%
Upside
52 Week's Low
52 Week's High
$10.91$33.4751.81%
Downside
47.84%
Upside
Spyre Therapeutics Inc share price movements today
- Previous Close
- $23.43
- Open
- $23.13
- Volume
- 429.9K
- Day's Low - High
- $22.47 - $23.57
- 52 Week Low - High
- $10.91 - $33.47
Spyre Therapeutics Inc Historical Returns
- 1 Month Return
- + 7.76 %
- 3 Month Return
- + 34.22 %
- 1 Year Return
- -27.63 %
- 3 Year Return
- 0 %
- 5 Year Return
- 0 %
Spyre Therapeutics Inc Stock Fundamentals & Key Indicators
Check Spyre Therapeutics Inc market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.
Market Cap
$1.8B
EPS (TTM)
-1.9915
Dividend Yield
0.00%
Quarterly Earnings Growth YOY
-1.00%
PE Ratio (TTM)
-3.91
Industry PE ratio
0PEG Ratio
0EBITDA
-207.8M
Revenue (TTM)
-
Profit Margin
0.00%
Return On Equity TTM
-38.08%
Spyre Therapeutics Inc Stock Valuation
Track how Spyre Therapeutics Inc P/E has moved over time to understand its valuation trends.
Spyre Therapeutics Inc in the last 5 years
Lowest (-8.58x)
September 30, 2025
Industry (0.00x)
November 14, 2025
Today (-3.91x)
November 14, 2025
Highest (-0.24x)
December 31, 2023
Today’s Price to Earnings Ratio: -3.91x
Spyre Therapeutics Inc vs Peer Comparison
Compare market cap, revenue, PE, and other key metrics of Spyre Therapeutics Inc with its industry peers.
Company | Analyst View | Market Cap | 5 Years Return % | PE Ratio | Profit Margin % |
|---|---|---|---|---|---|
| BUY | $1.8B | NA | -3.91 | 0.00% | |
| BUY | $59.8B | 235.01% | 1414.81 | 1.36% | |
| NA | $40.9B | NA | 712.21 | 1.38% | |
| BUY | $110.2B | 92.67% | 30.58 | 31.35% | |
| BUY | $71.6B | 22.7% | 16.34 | 32.13% |
Stock Returns calculator for Spyre Therapeutics Inc Stock including INR - Dollar returns
The Spyre Therapeutics Inc stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.
*Dollar Return is the profit earned when the US dollar rises in value compared to the Indian rupee.
Investment Value
₹1,00,000
Spyre Therapeutics Inc investment value today
Current value as on today
₹77,539
Returns
Returns from Spyre Therapeutics Inc Stock
Dollar Returns*
₹5,138 (+5.14%)
Analyst Recommendation on Spyre Therapeutics Inc Stock
Based on 13 analysts
92.31%
Buy
7.69%
Hold
0.00%
Sell
Based on 13 analysts, 92.31% of analysts recommend a 'BUY' rating for Spyre Therapeutics Inc. Average target price of $52.73
Spyre Therapeutics Inc Share Price Target
Get share price movements and forecasts by analysts on Spyre Therapeutics Inc.
What analysts predicted
57.06%UPSIDE
Target Price
$52.73
Current Price
$22.64
Analyzed by
13 Analysts
Target
$52.73
Spyre Therapeutics Inc target price $52.73, a slight upside of 57.06% compared to current price of $22.64. According to 13 analysts rating.
Spyre Therapeutics Inc Stock’s Investor Sentiment and Interest
Search interest for Spyre Therapeutics Inc Stock has increased by 200% in the last 30 days, reflecting an upward trend in search activity.
Time period: to
Change:200% versus previous 30 day period
Spyre Therapeutics Inc Quarterly Profit & Loss
All numbers in Millions USD
Spyre Therapeutics Inc Annual Profit & Loss
All numbers in Millions USD
Spyre Therapeutics Inc Quarterly Cash Flow
All numbers in Millions USD
Spyre Therapeutics Inc Annual Cash Flow
All numbers in Millions USD
Spyre Therapeutics Inc News & Key Events
Today's Timeline - 13 October
Tue, 01:31 AM
-Spyre Therapeutics announces proposed public offering of common stock and pre-funded warrants.
Tue, 06:38 AM
-Spyre Therapeutics prices public offering at $18.50 per share, aiming to raise $275 million.
Insights on Spyre Therapeutics Inc
Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.
POSITIVE IMPACTRevenue Rich
Revenue is up for the last 4 quarters, 168.0K → 1.04M (in $), with an average increase of 40.1% per quarter
- POSITIVE IMPACT
Price Rise
In the last 3 months, SYRE stock has moved up by 34.2%
- POSITIVE IMPACT
Profit Spike
Netprofit is up for the last 5 quarters, -69.02M → -11.18M (in $), with an average increase of 74.7% per quarter
NO EFFECTAgainst Peers
In the last 3 years, Alnylam Pharmaceuticals, Inc. has given 81.5% return, outperforming this stock by 114.9%
- NO EFFECT
Against Peers
In the last 1 year, Beone Medicines Ltd has given 90.6% return, outperforming this stock by 118.2%
About Spyre Therapeutics Inc
| Organisation | Spyre Therapeutics Inc |
| Headquarters | 221 Crescent Street, Waltham, MA, United States, 02453 |
| CEO | Dr. Cameron Turtle DPHIL, Ph.D. |
| E-voting on shares | Click here to vote |
Key Management of Spyre Therapeutics Inc
Name | Title |
|---|---|
Dr. Cameron Turtle DPHIL, Ph.D. | CEO & Director |
Mr. Scott L. Burrows | Chief Financial Officer |
Dr. Sheldon Sloan M.B.E., M.D. | Chief Medical Officer |
Mr. Brian Connolly | Chief Technical Officer |
Dr. Justin LaFountaine Ph.D. | Senior Vice President of Corporate Development |
Ms. Melissa Cooper | Senior Vice President of People |
Dr. Janet Gunzner-Toste M.B.A., Ph.D. | Senior Vice President of Operations |
Mr. Eric McIntyre | Vice President of Finance & Investor Relations |
Ms. Heidy Abreu King-Jones J.D., L.L.M. | Chief Legal Officer & Corporate Secretary |
Mr. James Myers | Vice President of Quality & Compliance |
FAQs
What is Spyre Therapeutics Inc share price today?
Spyre Therapeutics Inc share price today is $22.64 as on at the close of the market. Spyre Therapeutics Inc share today touched a day high of $23.57 and a low of $22.47.
What is the 52 week high and 52 week low for Spyre Therapeutics Inc share?
Spyre Therapeutics Inc share touched a 52 week high of $33.47 on and a 52 week low of $10.91 on . Spyre Therapeutics Inc stock price today i.e. is closed at $22.64,which is 32.36% down from its 52 week high and 107.52% up from its 52 week low.
What is Spyre Therapeutics Inc's market capitalisation today?
Spyre Therapeutics Inc market capitalisation is $0.00T as on .
How to invest in Spyre Therapeutics Inc Stock (SYRE) from India?
- Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
- Step 2: Search for Spyre Therapeutics Inc on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Spyre Therapeutics Inc Shares that will get you 0.0663 shares as per Spyre Therapeutics Inc share price of $22.64 per share as on November 14, 2025 at 2:29 am IST.
What is the minimum amount required to buy Spyre Therapeutics Inc Stock (SYRE) from India?
Indian investors can start investing in Spyre Therapeutics Inc (SYRE) shares with as little as ₹88.652 or $1 (as of ) using the INDmoney app.
For example: If you want to invest $10 or ₹886.52 in Spyre Therapeutics Inc stock (as per the Rupee-Dollar exchange rate as on ).
Based on Spyre Therapeutics Inc share’s latest price of $22.64 as on November 14, 2025 at 2:29 am IST, you will get 0.4417 shares of Spyre Therapeutics Inc. Learn more about
fractional shares .