Prothena Corporation Plc share price logo

Prothena Corporation Plc Share Price

NASDAQ: PRTA

Small Cap

$8.05

-0.11

(-1.29%)

as on

Prothena Corporation Plc Stock Performance

as on September 18, 2025 at 1:29 am IST

  • Day's Low

    Day's High

    $8.04
    $8.38
    downward going graph

    0.12%

    Downside

    4.10%

    Upside

    downward going graph
  • 52 Week's Low

    52 Week's High

    $4.32
    $22.41
    downward going graph

    46.34%

    Downside

    178.39%

    Upside

    downward going graph

Prothena Corporation Plc share price movements today

Previous Close
$8.16
Open
$8.19
Volume
543.6K
Day's Low - High
$8.04 - $8.38
52 Week Low - High
$4.32 - $22.41

Prothena Corporation Plc Historical Returns

1 Month Return
-1.09 %
3 Month Return
+ 43.16 %
1 Year Return
-62.81 %
3 Year Return
-72.28 %
5 Year Return
-21.54 %

Prothena Corporation Plc Stock Fundamentals & Key Indicators

Check Prothena Corporation Plc market cap, PE, PB, PEG ratios, dividend yield, and other key fundamental indicators.

Market Cap

$439.3M

EPS (TTM)

-4.59

Dividend Yield

0.00%

Quarterly Earnings Growth YOY

0.00%

PE Ratio (TTM)

-22.77

Industry PE ratio

-3.9281873111782475

P/B Ratio

0

PEG Ratio

0.8

EBITDA

-248.1M

Revenue (TTM)

10.3M

Profit Margin

0.00%

Return On Equity TTM

0.00%

Prothena Corporation Plc Stock Valuation

Track how Prothena Corporation Plc P/E has moved over time to understand its valuation trends.

Prothena Corporation Plc in the last 5 years

  • Overview

  • Trends

Lowest (29.55x)

March 31, 2022

Today (-22.77x)

September 17, 2025

Industry (-3.93x)

September 17, 2025

Highest (60.30x)

September 30, 2021

LowHigh

Today’s Price to Earnings Ratio: -22.77x

Prothena Corporation Plc vs Peer Comparison

Compare market cap, revenue, PE, and other key metrics of Prothena Corporation Plc with its industry peers.

Company
Analyst View
Market Cap
5 Years Return %PE RatioProfit Margin %
BUY$439.3M-21.54%-22.770.00%
BUY$60.5B252.04%-505.15-12.96%
NA$39.0BNANA-3.89%
BUY$100.3B44.17%27.8531.86%
BUY$59.6B1.78%14.131.37%

Stock Returns calculator for Prothena Corporation Plc Stock including INR - Dollar returns

The Prothena Corporation Plc stock calculator helps Indian investors calculate returns based on the historical performance of the stock. Just choose your investment amount and duration to get insights and invest more confidently. See stock returns as well as the effect of dollar appreciation over different durations.

*Dollar Return is the profit earned when the US dollar rises in value compared to the Indian rupee.

Investment Value

₹1,00,000

  • 1Y

  • 3Y

  • 5Y

  • 7Y

  • 10Y

Prothena Corporation Plc investment value today

Current value as on today

₹41,289

Returns

₹58,711

(-58.71%)

Returns from Prothena Corporation Plc Stock

₹63,309 (-63.31%)

Dollar Returns*

₹4,598 (+4.6%)

Analyst Recommendation on Prothena Corporation Plc Stock

Based on 17 analysts

BUY

76.47%

Buy

23.53%

Hold

0.00%

Sell

Based on 17 analysts, 76.47% of analysts recommend a 'BUY' rating for Prothena Corporation Plc. Average target price of $12

Prothena Corporation Plc Share Price Target

Get share price movements and forecasts by analysts on Prothena Corporation Plc.

What analysts predicted

32.92%UPSIDE

Target Price

$12

Current Price

$8.05

Analyzed by

17 Analysts

Target

$12.00

Prothena Corporation Plc target price $12, a slight upside of 32.92% compared to current price of $8.05. According to 17 analysts rating.

Prothena Corporation Plc Stock's Interest Amongst Investors

Search interest for Prothena Corporation Plc Stock has decreased by -36% in the last 30 days, reflecting a downward trend in search activity.

Time period: to

Change:-36%Ā versus previous 30 day period

Prothena Corporation Plc Quarterly Profit & Loss

All numbers in Millions USD

Mar 2023
Jun 2023
Sep 2023
Dec 2023
Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Total Revenue
2
4
84
0
0
132
0
2
2
4
Gross Profit
0
2
82
-13
0
74
0
1
2
4
Operating Income
-56
-66
10
-78
-81
58
-66
-64
-65
-84
EBITDA
-56
-66
10
-69
-81
58
-66
-64
-65
-51
Interest Expense
6
7
-
6
-
-
-
-
-
-
Depreciation
0
0
5
-4
0
0
0
0
0
0
Income Before Tax
-49
-58
18
-70
-74
64
-59
-59
-61
-80
Income Tax Expense
-2
-4
-3
-3
-2
-2
0
-1
-1
44
Net Income
-46
-54
21
-67
-72
66
-59
-57
-60
-125
Net Profit Margin
-2160.63%
-1358.42%
25.81%
-21353.16%
-144478.00%
50.67%
-6082.58%
-2729.91%
-2128.54%
-2845.41%

Prothena Corporation Plc Annual Profit & Loss

All numbers in Millions USD

Dec 2015
Dec 2016
Dec 2017
Dec 2018
Dec 2019
Dec 2020
Dec 2021
Dec 2022
Dec 2023
Dec 2024
Total Revenue
1
1
27
0
0
0
200
53
91
135
Gross Profit
1
1
27
-100
-50
0
200
53
-129
135
Operating Income
-79
-159
-155
-158
-85
-112
71
-131
-191
-154
EBITDA
-79
-157
-152
-152
-78
-105
78
-130
-190
-154
Interest Expense
-
0
3
3
8
8
6
6
-
-
Depreciation
-
-
3
3
6
6
6
0
0
0
Income Before Tax
-79
-158
-157
-156
-77
-111
71
-125
-160
-128
Income Tax Expense
0
1
-4
0
0
0
4
-8
-13
-6
Net Income
-80
-160
-153
-155
-77
-111
66
-116
-147
-122
Net Profit Margin
-5016.30%
-15176.11%
-556.84%
-16297.91%
-9542.63%
-13029.78%
33.39%
-216.95%
-160.91%
-90.49%

Prothena Corporation Plc Quarterly Cash Flow

All numbers in Millions USD

Jun 2023
Sep 2023
Dec 2023
Mar 2024
Jun 2024
Sep 2024
Dec 2024
Mar 2025
Jun 2025
Net Income
-54
21
-67
-72
66
-59
-57
-60
-125
Operating Cash Flow
-44
9
-51
-73
16
-45
-47
-53
-50
Investing Cash Flow
0
0
-1
0
0
0
0
0
0
Financing Cash Flow
18
2
0
0
0
0
0
0
0
Change in Cash
-27
11
-52
-72
16
-44
-47
-53
-46

Prothena Corporation Plc Annual Cash Flow

All numbers in Millions USD

Dec 2016
Dec 2017
Dec 2018
Dec 2019
Dec 2020
Dec 2021
Dec 2022
Dec 2023
Dec 2024
Net Income
-160
-153
-155
-77
-111
66
-116
-147
-122
Operating Cash Flow
-117
-131
-28
-52
-80
92
-108
-133
-150
Investing Cash Flow
-16
-3
-1
0
0
0
0
-2
0
Financing Cash Flow
154
165
40
0
0
190
241
45
1
Change in Cash
20
30
10
-53
-80
282
132
-91
-148

Global Institutional Holdings in Prothena Corporation Plc

Funds
Holdings
EcoR1 Capital, LLC
21.52%
FMR Inc
14.75%
Wellington Management Company LLP
9.66%
BlackRock Inc
7.51%
T. Rowe Price Associates, Inc.
6.42%

Insights on Prothena Corporation Plc

Insights help you understand the recent movement of the company's critical parameters, giving you an overall view of the company.

  • imgPOSITIVE IMPACT

    Revenue Rich

    img

    Revenue is up for the last 4 quarters, 970.0K → 4.42M (in $), with an average increase of 38.4% per quarter

  • imgNO EFFECT

    Against Peers

    img

    In the last 1 year, Alnylam Pharmaceuticals, Inc. has given 68.9% return, outperforming this stock by 130.9%

  • imgNO EFFECT

    Against Peers

    img

    In the last 3 years, Alnylam Pharmaceuticals, Inc. has given 116.5% return, outperforming this stock by 188.8%

  • imgNEGATIVE IMPACT

    Price Dip

    img

    In the last 6 months, PRTA stock has moved down by -36.4%

  • imgNEGATIVE IMPACT

    Profit Down

    img

    Netprofit is down for the last 3 quarters, -57.95M → -125.76M (in $), with an average decrease of 56.4% per quarter

About Prothena Corporation Plc

prothena corporation plc (nasdaq: prta) is a late-stage clinical biotechnology company focused on the discovery, development and commercialization of novel protein immunotherapy programs for the potential treatment of diseases that involve amyloid or cell adhesion. the company focuses on therapeutic monoclonal antibodies directed specifically to disease-causing proteins, and its antibody-based product candidates target a number of potential indications, including al amyloidosis (neod001), parkinson’s disease and other related synucleinopathies (prx002), and novel cell adhesion targets involved in psoriasis and other inflammatory diseases (prx003). our lead program, neod001, is in a global phase 3 registration clinical trial – the vital amyloidosis study. there is also an on-going phase 1/2 trial. prx002 is in a phase 1 multiple ascending dose clinical trial, and prx003 is in a phase 1 single ascending dose clinical trial. prothena’s elite team has a recognized track record both f
OrganisationProthena Corporation Plc
Headquarters77 Sir John Rogerson?s Quay, Dublin, Ireland, D02 VK60
IndustryHealth Technology
CEODr. Gene G. Kinney Ph.D.
E-voting on sharesClick here to vote

Key Management of Prothena Corporation Plc

Name

Title

Mr. Brandon S. Smith

Chief Operating Officer

Dr. Wagner M. Zago Ph.D.

Chief Scientific Officer

Ms. Karin L. Walker CPA

Chief Accounting Officer & Controller

Mr. Mark C. Johnson C.F.A.

Vice President of Investor Relations

Mr. Michael J. Malecek

Chief Legal Officer & Company Secretary

Dr. Chad H. Swanson Ph.D.

Chief Development Officer

Dr. Gene G. Kinney Ph.D.

President, CEO & Director

Mr. Tran B. Nguyen M.B.A.

CFO & Chief Strategy Officer

FAQs

What is Prothena Corporation Plc share price today?

Prothena Corporation Plc share price today is $8.05 as on at the close of the market. Prothena Corporation Plc share today touched a day high of $8.38 and a low of $8.04.

What is the 52 week high and 52 week low for Prothena Corporation Plc share?

Prothena Corporation Plc share touched a 52 week high of $22.41 on and a 52 week low of $4.32 on . Prothena Corporation Plc stock price today i.e. is closed at $8.05,which is 64.08% down from its 52 week high and 86.34% up from its 52 week low.

What is Prothena Corporation Plc's market capitalisation today?

Prothena Corporation Plc market capitalisation is $0.00T as on .

How to invest in Prothena Corporation Plc Stock (PRTA) from India?

  1. Step 1: Open a free US stocks account on INDmoney App and transfer your Rupees into Dollars to your INDmoney US stocks account. For a step by step instruction, check How to Transfer Money to Your US Stocks Account .
  2. Step 2: Search for Prothena Corporation Plc on INDmoney app. Click on Buy button. You can invest as low as $1.5 in Prothena Corporation Plc Shares that will get you 0.1863 shares as per Prothena Corporation Plc share price of $8.05 per share as on September 18, 2025 at 1:29 am IST.

What is the minimum amount required to buy Prothena Corporation Plc Stock (PRTA) from India?

Indian investors can start investing in Prothena Corporation Plc (PRTA) shares with as little as ₹87.816 or $1 (as of ) using the INDmoney app.
For example: If you want to invest $10 or ₹878.16 in Prothena Corporation Plc stock (as per the Rupee-Dollar exchange rate as on ). Based on Prothena Corporation Plc share’s latest price of $8.05 as on September 18, 2025 at 1:29 am IST, you will get 1.2422 shares of Prothena Corporation Plc. Learn more about fractional shares .

What are the returns that Prothena Corporation Plc has given to Indian investors in the last 5 years?

Prothena Corporation Plc stock has given -21.54% share price returns and 20.01% dollar appreciation to an Indian investor in the last 5 years.
Read more about How do Currency Exchange Rates impact your returns on US Stock Investments?